●1jgjの疎水性インデックス ※アミノ酸の親水性・疎水性参照
MVGLTTLFWLGAIGMLVGTLAFAWAGRDAGSGERRYYVTLVGISGIAAVAYAVMALGVGWV
PVAERTVFVPRYIDWILTTPLIVYFLGLLAGLDSREFGIVITLNTVVMLAGFAGAMVPG
IERYALFGMGAVAFIGLVYYLVGPMTESASQRSSGIKSLYVRLRNLTVVLWAIYPFIW
LLGPPGVALLTPTVDVALIVYLDLVTKVGFGFIALDAAA
No. | a | 1 | b | 2 | c | 3 | d | 4 | e | 5 | f | 6 | g | 7 | h |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
アミノ酸数 n | 3 | 23 | 12 | 23 | 12 | 22 | 2 | 23 | 5 | 23 | 7 | 23 | 10 | 23 | 6 |
hydropathy index 平均値 |
1.900 | 1.604 | -1.558 | 1.878 | -0.042 | 1.423 | -4.000 | 1.743 | -1.875 | 1.335 | -1.286 | 0.957 | 1.720 | 1.396 | 1.250 |
1jgjの膜貫通部分の参照
※初期表示では,膜貫通部分を疎水性インデックス順着色で球棒表示,他を水色表示
●1jgj |
※amino表示の凡例 ASP GLU CYS MET LYS ARG SER THR PHE TYR ASN GLN GLY LEU VAL ILE ALA TRP HIS PRO = 以下の表示はアミノ酸の親水性・疎水性参照 = ※酸性・中性〈芳香族〉・塩基性アミノ酸区別表示の凡例 ASP GLU GLY ALA VAL LEU ILE CYS SER THR ASN GLN PRO MET PHE TYR TRP LYS ARG HIS ※極性〈酸性・塩基性〉・非極性(疎水性)アミノ酸区別 SER THR TYR CYS ASN GLN ASP GLU LYS ARG HIS GLY ALA VAL LEU ILE PHE PRO MET TRP ※疎水性インデックス順 ARG LYS ASN ASP GLN GLU HIS PRO TYR TRP SER THR GLY ALA MET CYS PHE LEU VAL ILE ※等電点順 ASP GLU CYS ASN PHE GLN TYR SER MET TRP VAL GLY LEU ALA ILE THR PRO HIS LYS ARG |
1jgjの膜貫通部分(上)とそれ以外の部分(下)の疎水性インデックス値の分布
1jgjの膜貫通部分とそれ以外の部分のアミノ酸配列の違い
ARG LYS ASN ASP GLN GLU HIS PRO TYR TRP SER THR GLY ALA MET CYS PHE LEU VAL ILE
膜貫通部分 | 1 | Leu | Thr | Thr | Leu | Phe | Trp | Leu | Gly | Ala | Ile | Gly | Met | Leu | Val | Gly | Thr | Leu | Ala | Phe | Ala | Trp | Ala | Gly |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2 | Thr | Leu | Val | Gly | Ile | Ser | Gly | Ile | Ala | Ala | Val | Ala | Tyr | Ala | Val | Met | Ala | Leu | Gly | Val | Gly | Trp | Val | |
3 | Ile | Asp | Trp | Ile | Leu | Thr | Thr | Pro | Leu | Ile | Val | Tyr | Phe | Leu | Gly | Leu | Leu | Ala | Gly | Leu | Asp | Ser | ||
4 | Phe | Gly | Ile | Val | Ile | Thr | Leu | Asn | Thr | Val | Val | Met | Leu | Ala | Gly | Phe | Ala | Gly | Ala | Met | Val | Pro | Gly | |
5 | Leu | Phe | Gly | Met | Gly | Ala | Val | Ala | Phe | Ile | Gly | Leu | Val | Tyr | Tyr | Leu | Val | Gly | Pro | Met | Thr | Glu | Ser | |
6 | Ile | Lys | Ser | Leu | Tyr | Val | Arg | Leu | Arg | Asn | Leu | Thr | Val | Val | Leu | Trp | Ala | Ile | Tyr | Pro | Phe | Ile | Trp | |
7 | Thr | Pro | Thr | Val | Asp | Val | Ala | Leu | Ile | Val | Tyr | Leu | Asp | Leu | Val | Thr | Lys | Val | Gly | Phe | Gly | Phe | Ile | |
膜貫通以外 | a | Met | Val | Gly | ||||||||||||||||||||
b | Arg | Asp | Ala | Gly | Ser | Gly | Glu | Arg | Arg | Tyr | Tyr | Val | ||||||||||||
c | Pro | Val | Ala | Glu | Arg | Thr | Val | Phe | Val | Pro | Arg | Tyr | ||||||||||||
d | Arg | Glu | ||||||||||||||||||||||
e | Ile | Glu | Arg | Tyr | Ala | |||||||||||||||||||
f | Ala | Ser | Gln | Arg | Ser | Ser | Gly | |||||||||||||||||
g | Leu | Leu | Gly | Pro | Pro | Gly | Val | Ala | Leu | Leu | ||||||||||||||
h | Ala | Leu | Asp | Ala | Ala | Ala |
1jgjの膜貫通部分とそれ以外の部分それぞれを構成するアミノ酸のhydropathy index値の違い
-4.5 〜 -3.9|-3.5 〜 -3.2|-1.6 〜 -0.4|1.8 〜 2.8|4.2 〜 4.5
膜貫通部分 | 1 | 3.8 | -0.7 | -0.7 | 3.8 | 2.8 | -0.9 | 3.8 | -0.4 | 1.8 | 4.5 | -0.4 | 1.9 | 3.8 | 4.2 | -0.4 | -0.7 | 3.8 | 1.8 | 2.8 | 1.8 | -0.9 | 1.8 | -0.4 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2 | -0.7 | 3.8 | 4.2 | -0.4 | 4.5 | -0.8 | -0.4 | 4.5 | 1.8 | 1.8 | 4.2 | 1.8 | -1.3 | 1.8 | 4.2 | 1.9 | 1.8 | 3.8 | -0.4 | 4.2 | -0.4 | -0.9 | 4.2 | |
3 | 4.5 | -3.5 | -0.9 | 4.5 | 3.8 | -0.7 | -0.7 | -1.6 | 3.8 | 4.5 | 4.2 | -1.3 | 2.8 | 3.8 | -0.4 | 3.8 | 3.8 | 1.8 | -0.4 | 3.8 | -3.5 | -0.8 | ||
4 | 2.8 | -0.4 | 4.5 | 4.2 | 4.5 | -0.7 | 3.8 | -3.5 | -0.7 | 4.2 | 4.2 | 1.9 | 3.8 | 1.8 | -0.4 | 2.8 | 1.8 | -0.4 | 1.8 | 1.9 | 4.2 | -1.6 | -0.4 | |
5 | 3.8 | 2.8 | -0.4 | 1.9 | -0.4 | 1.8 | 4.2 | 1.8 | 2.8 | 4.5 | -0.4 | 3.8 | 4.2 | -1.3 | -1.3 | 3.8 | 4.2 | -0.4 | -1.6 | 1.9 | -0.7 | -3.5 | -0.8 | |
6 | 4.5 | -3.9 | -0.8 | 3.8 | -1.3 | 4.2 | -4.5 | 3.8 | -4.5 | -3.5 | 3.8 | -0.7 | 4.2 | 4.2 | 3.8 | -0.9 | 1.8 | 4.5 | -1.3 | -1.6 | 2.8 | 4.5 | -0.9 | |
7 | -0.7 | -1.6 | -0.7 | 4.2 | -3.5 | 4.2 | 1.8 | 3.8 | 4.5 | 4.2 | -1.3 | 3.8 | -3.5 | 3.8 | 4.2 | -0.7 | -3.9 | 4.2 | -0.4 | 2.8 | -0.4 | 2.8 | 4.5 | |
膜貫通以外 | a | 1.9 | 4.2 | -0.4 | ||||||||||||||||||||
b | -4.5 | -3.5 | 1.8 | -0.4 | -0.8 | -0.4 | -3.5 | -4.5 | -4.5 | -1.3 | -1.3 | 4.2 | ||||||||||||
c | -1.6 | 4.2 | 1.8 | -3.5 | -4.5 | -0.7 | 4.2 | 2.8 | 4.2 | -1.6 | -4.5 | -1.3 | ||||||||||||
d | -4.5 | -3.5 | ||||||||||||||||||||||
e | 4.5 | -3.5 | -4.5 | -1.3 | 1.8 | |||||||||||||||||||
f | 1.8 | -0.8 | -3.5 | -4.5 | -0.8 | -0.8 | -0.4 | |||||||||||||||||
g | 3.8 | 3.8 | -0.4 | -1.6 | -1.6 | -0.4 | 4.2 | 1.8 | 3.8 | 3.8 | ||||||||||||||
h | 1.8 | 3.8 | -3.5 | 1.8 | 1.8 | 1.8 |
●1occのA鎖の疎水性インデックス(12回膜貫通;貫通部分のみ)
1 | Leu | Leu | Phe | Gly | Ala | Trp | Ala | Gly | Met | Val | Gly | Thr | Ala | Leu | Ser | Leu | Leu | Ile | Arg | Ala | Glu | Leu | Gly |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2 | Phe | Val | Met | Ile | Phe | Phe | Met | Val | Met | Pro | Ile | Met | Ile | Gly | Gly | Phe | Gly | Asn | Trp | Leu | Val | Pro | Leu |
3 | Asn | Met | Ser | Phe | Trp | Leu | Leu | Pro | Pro | Ser | Phe | Leu | Leu | Leu | Leu | Ala | Ser | Ser | Met | Val | Glu | Ala | Gly |
4 | Ile | Phe | Ser | Leu | His | Leu | Ala | Gly | Val | Ser | Ser | Ile | Leu | Gly | Ala | Ile | Asn | Phe | Ile | Thr | Thr | Ile | Ile |
5 | Trp | Ser | Val | Met | Ile | Thr | Ala | Val | Leu | Leu | Leu | Leu | Ser | Leu | Pro | Val | Leu | Ala | Ala | Gly | Ile | Thr | Met |
6 | Pro | Glu | Val | Tyr | Ile | Leu | Ile | Leu | Pro | Gly | Phe | Gly | Met | Ile | Ser | His | Ile | Val | Thr | Tyr | Tyr | Ser | Gly |
7 | Tyr | Met | Gly | Met | Val | Trp | Ala | Met | Met | Ser | Ile | Gly | Phe | Leu | Gly | Phe | Ile | Val | Trp | Ala | His | His | Met |
8 | Ser | Ala | Thr | Met | Ile | Ile | Ala | Ile | Pro | Thr | Gly | Val | Lys | Val | Phe | Ser | Trp | Leu | Ala | Thr | Leu | His | Gly |
9 | Met | Trp | Ala | Leu | Gly | Phe | Ile | Phe | Leu | Phe | Thr | Val | Gly | Gly | Leu | Thr | Gly | Ile | Val | Leu | Ala | Asn | Ser |
10 | Ala | His | Phe | His | Tyr | Val | Leu | Ser | Met | Gly | Ala | Val | Phe | Ala | Ile | Met | Gly | Gly | Phe | Val | His | Trp | Phe |
11 | Trp | Ala | Lys | Ile | His | Phe | Ala | Ile | Met | Phe | Val | Gly | Val | Asn | Met | Thr | Phe | Phe | Pro | Gln | His | Phe | Leu |
12 | Met | Gly | Ser | Phe | Ile | Ser | Leu | Thr | Ala | Val | Met | Leu | Met | Val | Phe | Ile | Ile | Trp | Glu | Ala | Phe | Ala | Ser |
1 | 3.8 | 3.8 | 2.8 | -0.4 | 1.8 | -0.9 | 1.8 | -0.4 | 1.9 | 4.2 | -0.4 | -0.7 | 1.8 | 3.8 | -0.8 | 3.8 | 3.8 | 4.5 | -4.5 | 1.8 | -3.5 | 3.8 | -0.4 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2 | 2.8 | 4.2 | 1.9 | 4.5 | 2.8 | 2.8 | 1.9 | 4.2 | 1.9 | -1.6 | 4.5 | 1.9 | 4.5 | -0.4 | -0.4 | 2.8 | -0.4 | -3.5 | -0.9 | 3.8 | 4.2 | -1.6 | 3.8 |
3 | -3.5 | 1.9 | -0.8 | 2.8 | -0.9 | 3.8 | 3.8 | -1.6 | -1.6 | -0.8 | 2.8 | 3.8 | 3.8 | 3.8 | 3.8 | 1.8 | -0.8 | -0.8 | 1.9 | 4.2 | -3.5 | 1.8 | -0.4 |
4 | 4.5 | 2.8 | -0.8 | 3.8 | -3.2 | 3.8 | 1.8 | -0.4 | 4.2 | -0.8 | -0.8 | 4.5 | 3.8 | -0.4 | 1.8 | 4.5 | -3.5 | 2.8 | 4.5 | -0.7 | -0.7 | 4.5 | 4.5 |
5 | -0.9 | -0.8 | 4.2 | 1.9 | 4.5 | -0.7 | 1.8 | 4.2 | 3.8 | 3.8 | 3.8 | 3.8 | -0.8 | 3.8 | -1.6 | 4.2 | 3.8 | 1.8 | 1.8 | -0.4 | 4.5 | -0.7 | 1.9 |
6 | -1.6 | -3.5 | 4.2 | -1.3 | 4.5 | 3.8 | 4.5 | 3.8 | -1.6 | -0.4 | 2.8 | -0.4 | 1.9 | 4.5 | -0.8 | -3.2 | 4.5 | 4.2 | -0.7 | -1.3 | -1.3 | -0.8 | -0.4 |
7 | -1.3 | 1.9 | -0.4 | 1.9 | 4.2 | -0.9 | 1.8 | 1.9 | 1.9 | -0.8 | 4.5 | -0.4 | 2.8 | 3.8 | -0.4 | 2.8 | 4.5 | 4.2 | -0.9 | 1.8 | -3.2 | -3.2 | 1.9 |
8 | -0.8 | 1.8 | -0.7 | 1.9 | 4.5 | 4.5 | 1.8 | 4.5 | -1.6 | -0.7 | -0.4 | 4.2 | -3.9 | 4.2 | 2.8 | -0.8 | -0.9 | 3.8 | 1.8 | -0.7 | 3.8 | -3.2 | -0.4 |
9 | 1.9 | -0.9 | 1.8 | 3.8 | -0.4 | 2.8 | 4.5 | 2.8 | 3.8 | 2.8 | -0.7 | 4.2 | -0.4 | -0.4 | 3.8 | -0.7 | -0.4 | 4.5 | 4.2 | 3.8 | 1.8 | -3.5 | -0.8 |
10 | 1.8 | -3.2 | 2.8 | -3.2 | -1.3 | 4.2 | 3.8 | -0.8 | 1.9 | -0.4 | 1.8 | 4.2 | 2.8 | 1.8 | 4.5 | 1.9 | -0.4 | -0.4 | 2.8 | 4.2 | -3.2 | -0.9 | 2.8 |
11 | -0.9 | 1.8 | -3.9 | 4.5 | -3.2 | 2.8 | 1.8 | 4.5 | 1.9 | 2.8 | 4.2 | -0.4 | 4.2 | -3.5 | 1.9 | -0.7 | 2.8 | 2.8 | -1.6 | -3.5 | -3.2 | 2.8 | 3.8 |
12 | 1.9 | -0.4 | -0.8 | 2.8 | 4.5 | -0.8 | 3.8 | -0.7 | 1.8 | 4.2 | 1.9 | 3.8 | 1.9 | 4.2 | 2.8 | 4.5 | 4.5 | -0.9 | -3.5 | 1.8 | 2.8 | 1.8 | -0.8 |
1occ Chain Aの膜貫通部分各ブロックの疎水性インデックス値の平均値(全平均は 1.422)