Molecular Structure of Cytochrome P450
[ Japanese version ]

  • Radio button I: Select I helix (the longest helix in the molecule).
  • Radio button P(n): Select CASTp pocket id = n.
  • #, ##: Arranged data.

1akd##   <PDB>   [Oxidoreductase | P450cam]   I   P(53)
    Cytochrome P450Cam From Pseudomonas Putida, Complexed With 1S-Camphor.

2bmh (Chain A) <PDB>   [Oxidoreductase(Oxygenase) | P450BM3]   I   P(135)
    Modeling Protein-Substrate Interactions in the Heme Domain of Cytochrome P450Bm-3.

1bu7 (Chain A)  <PDB>   [Oxidoreductase | P450BM3]   I
    Cryogenic Structure Of Cytochrome P450Bm-3 Heme Domain.

1bvy (Chain A)  <PDB>   [Oxidoreductase | P450BM3]   I
    Complex Of The Heme and Fmn-Binding Domains Of The Cytochrome P450(Bm-3).

1c8j (Chain A)  <PDB>   [Oxidoreductase | P450cam]   I
    Crystal Structure Of Cytochrome P450Cam Mutant (F87W/Y96F).

1cl6   <PDB>   [Oxidoreductase | P450nor]   I   P(51)
    Crystal Structures Of Ferric-No Complexes Of Fungal Nitric Oxide Reductase and Its Ser286 Mutants At Cryogenic Temperature.

1cmj   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structures Of Ferric-No Complexes Of Fungal Nitric Oxide Reductase and Their Ser286 Mutants At Cryogenic Temperature.

1cmn   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structures Of Ferric-No Complexes Of Fungal Nitric Oxide Reductase and Their Ser286 Mutants At Cryogenic Temperature.

1cp4   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Formation, crystal structure, and rearrangement of a cytochrome P-450cam iron-phenyl complex.

2cp4   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala.

3cp4   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala.

4cp4   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala.

5cp4   <PDB>   [Oxidoreductase | P450cam]   I
    Cryogenic Structure Of P450Cam.

6cp4   <PDB>   [Oxidoreductase | P450cam]   I
    P450Cam D251N Mutant.

2cpp   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    High-resolution crystal structure of cytochrome P450cam.

3cpp   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structure of the carbon monoxide-substrate-cytochrome P-450CAM ternary complex.

4cpp   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation.

5cpp   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM.

6cpp   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation.

7cpp   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM.

8cpp   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation.

1cpt   <PDB>   [Oxidoreductase(Oxygenase) | P450terp]   I
    CRYSTAL STRUCTURE AND REFINEMENT OF CYTOCHROME P450-TERP AT 2.3 ANGSTROMS RESOLUTION.

1dt6   <PDB>   [Oxidoreductase | P450 2C5]   I
    Structure Of Mammalian Cytochrome P450 2C5.

1dz4 (Chain A)*#   <PDB>   [Oxidoreductase | P450cam]   I
    Ferric P450Cam From Pseudomonas Putida.

1dz6 (Chain A)*#   <PDB>   [Oxidoreductase | P450cam]   I
    Ferrous P450Cam From Pseudomonas Putida.

1dz8 (Chain A)*#   <PDB>   [Oxidoreductase | P450cam]   I   I'(13)   P(103)
    Oxygen Complex Of P450Cam From Pseudomonas Putida.

1dz9 (Chain A)*#   <PDB>   [Oxidoreductase | P450cam]   I
    Putative Oxo Complex Of P450Cam From Pseudomonas Putida.

1e9x   <PDB>   [Oxidoreductase | CYP51]   I
    Cytochrome P450 14 α-Sterol Demethylase (Cyp51) From Mycobacterium Tuberculosis In Complex With 4-Phenylimidazole.

1ea1*   <PDB>   [Oxidoreductase | CYP51]   I
    Cytochrome P450 14 α-Sterol Demethylase (Cyp51) From Mycobacterium Tuberculosis In Complex With Fluconazole.

1egy   <PDB>   [Oxidoreductase | P450eryF]   I
    Cytochrome P450Eryf With 9-Aminophenanthrene Bound.

1ehe   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structures Of Cytochrome P450Nor and Its Mutants (Ser286 Val, Thr) In The Ferric Resting State At Cryogenic Temperature: A Comparative Analysis With Monooxygenase Cytochrome P450S.

1ehf   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structures Of Cytochrome P450Nor and Its Mutants (Ser286 Val, Thr) In The Ferric Resting State At Cryogenic Temperature: A Comparative Analysis With Monooxygenase Cytochrome P450S.

1ehg   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structures Of Cytochrome P450Nor and Its Mutants (Ser286 Val, Thr) In The Ferric Resting State At Cryogenic Temperature: A Comparative Analysis With Monooxygenase Cytochrome P450S.

1eup*   <PDB>   [Oxidoreductase | P450eryF]   I
    X-Ray Crystal Structure Of Cytochrome P450Eryf With Androstendione Bound.

1f24   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structure Of No Complex Of Thr243Ala Mutants Of Cytochrome P450Nor.

1f25   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structure Of No Complex Of Thr243Asn Mutants Of Cytochrome P450Nor.

1f26   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structure Of No Complex Of Thr243Val Mutants Of Cytochrome P450Nor.

1f4t (Chain A)  <PDB>   [Oxidoreductase | CYP119]   I
    Thermophilic P450: Cyp119 From Sulfolobus Solfactaricus With 4-Phenylimidazole Bound.

1f4u (Chain A)  <PDB>   [Oxidoreductase | CYP119]   I
    Thermophilic P450: Cyp119 From Sulfolobus Solfactaricus.

2f9q (Chain A)  <PDB>   [Oxidoreductase | P450 2D6 | CYP2D6]
    Crystal Structure of Human Cytochrome P450 2D6.

1fag (Chain A)  <PDB>   [Electron Transport | P450BM3]   I
    Structure Of Cytochrome P450.

1fah (Chain A)  <PDB>   [Electron Transport | P450BM3]   I
    Structure Of Cytochrome P450.

1geb   <PDB>   [Electron Transport | P450cam]   I
    X-Ray Crystal Structure and Catalytic Properties Of Thr252Ile Mutant Of Cytochrome P450Cam.

1ged   <PDB>   [Oxidoreductase | P450 55A1 | P450nor]   I
    A Positive Charge Route For The Access Of Nadh To Heme Formed In The Distal Heme Pocket Of Cytochrome P450Nor.

1gei   <PDB>   [Oxidoreductase | P450 55A1 | P450nor]   I
    Structural Characterization Of N-Butyl-Isocyanide Complexes Of Cytochromes P450Nor and P450Cam.

1gej   <PDB>   [Oxidoreductase | P450 55A1 | P450nor]   I
    Structural Characterization Of N-Butyl-Isocyanide Complexes Of Cytochromes P450Nor and P450Cam.

1gek   <PDB>   [Oxidoreductase | P450cam]   I(31)
    Structural Characterization Of N-Butyl-Isocyanide Complexes Of Cytochromes P450Nor and P450Cam.

1gem   <PDB>   [Oxidoreductase | P450cam]   I
    Structural Characterization Of N-Butyl-Isocyanide Complexes Of Cytochromes P450Nor and P450Cam.

1gjm   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Covalent Attachment Of An Electroactive Sulphydryl Reagent In The Active Site Of Cytochrome P450Cam.

1gwi (Chain A)*#   <PDB>   [Oxidoreductase | P450 154C1]   I
    The 1.92 A Structure Of Streptomyces Coelicolor A3(2) Cyp154C1: A New Monooxygenase That Functionalizes Macrolide Ring Systems.

1h5z   <PDB>   [Oxidoreductase | CYP51]   I
    Cytochrome P450 14 α-Sterol Demethylase (Cyp51) From Mycobacterium Tuberculosis In Ferric Low-Spin State.

2hpd (Chain A)  <PDB>   [Oxidoreductase(Oxygenase) | P450BM3]   I
    Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's.

1io7 (Chain A)  <PDB>   [Oxidoreductase | CYP119]   I
    Thermophilic Cytochrome P450 (Cyp119) From Sulfolobus Solfataricus: High Resolution Structural Origin Of Its Thermostability and Functional Properties.

1io8 (Chain A)  <PDB>   [Oxidoreductase | CYP119]   I
    Thermophilic Cytochrome P450 (Cyp119) From Sulfolobus Solfataricus: High Resolution Structural Origin Of Its Thermostability and Functional Properties.

1io9 (Chain A)  <PDB>   [Oxidoreductase | CYP119]   I
    Thermophilic Cytochrome P450 (Cyp119) From Sulfolobus Solfataricus: High Resolution Structural Origin Of Its Thermostability and Functional Properties.

1iwi   <PDB>   [Oxidoreductase | P450cam]   I
    Putidaredoxin-Binding Stablilizes An Active Conformer Of Cytochrome P450Cam In Its Reduced State; Crystal Structure Of Cytochrome P450Cam.

1iwj   <PDB>   [Oxidoreductase | P450cam]   I
    Putidaredoxin-Binding Stablilizes An Active Conformer Of Cytochrome P450Cam In Its Reduced State; Crystal Structure Of Mutant(109K) Cytochrome P450Cam.

1iwk   <PDB>   [Oxidoreductase | P450cam]   I
    Putidaredoxin-Binding Stablilizes An Active Conformer Of Cytochrome P450Cam In Its Reduced State; Crystal Structure Of Mutant(112K) Cytochrome P450Cam.

1izo (Chain A)  <PDB>   [Oxidoreductase | P450 152A1 | P450Bsbeta]   I(31)   P(138)
    Cytochrome P450 Bsβ Complexed With Fatty Acid.

1j51 (Chain A)  <PDB>   [Oxidoreductase | P450cam]   I
    Crystal Structure Of Cytochrome P450Cam Mutant (F87W/Y96F/V247L/C334A) With 1,3,5-Trichlorobenzene.

1jfb   <PDB>   [Oxidoreductase | P450 55A1 | P450nor]   I
    X-Ray Structure Of Nitric Oxide Reductase (Cytochrome P450Nor) In The Ferric Resting State At Atomic Resolution.

1jfc   <PDB>   [Oxidoreductase | P450 55A1 | P450nor]   I
    X-Ray Structure Of Nitric Oxide Reductase (Cytochrome P450Nor) In The Ferrous Co State At Atomic Resolution.

1jin   <PDB>   [Hydrolase | P450 107A1 | P450eryF]   I
    P450Eryf/Ketoconazole.

1jio   <PDB>   [Hydrolase | P450 107A1 | P450eryF]   I
    P450Eryf/6Deb.

1jip   <PDB>   [Hydrolase | P450 107A1 | P450eryF]   I
    P450Eryf(A245S)/Ketoconazole.

1jme (Chain A)  <PDB>   [Oxidoreductase | P450BM3]   I
    Crystal Structure Of Phe393His Cytochrome P450 Bm3.

1jpz (Chain A)  <PDB>   [Oxidoreductase | P450 102 | P450BM3]   I  
    Crystal Structure Of A Complex Of The Heme Domain Of P450Bm- 3 With N-Palmitoylglycine.

1k2o (Chain A)  <PDB>   [Oxidoreductase | P450cam]   I
    Cytochrome P450Cam With Bound Bis(2,2'-Bipyridine)-(5- Methyl-2-2'-Bipyridine)-C2-Adamantane Ruthenium (II).

1lfk <PDB>   [Oxidoreductase | P450 Monooxygenase]   I
    Crystal Structure Of Oxyb, A Cytochrome P450 Implicated In An Oxidative Phenol Coupling Reaction During Vancomycin Biosynthesis.

1lg9 <PDB>   [Oxidoreductase | P450 Monooxygenase]   I
    Crystal Structure Of Oxyb, A Cytochrome P450 Implicated In An Oxidative Phenol Coupling Reaction During Vancomycin Biosynthesis.

1lgf <PDB>   [Oxidoreductase | P450 Monooxygenase]   I
    Crystal Structure Of Oxyb, A Cytochrome P450 Implicated In An Oxidative Phenol Coupling Reaction During Vancomycin Biosynthesis.

1lwl <PDB>   [Oxidoreductase | P450cam]   I
    Crystal Structure Of Cytochrome P450-Cam With A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide).

1mpw (Chain A) <PDB>   [Oxidoreductase | P450cam]   I
    Molecular Recognition In (+)-A-Pinene Oxidation By Cytochrome P450Cam.

1n40 <PDB>   [Oxidoreductase | CYP121]   I
    Atomic Structure Of Cyp121, A Mycobacterial P450.

1n4g <PDB>   [Oxidoreductase | CYP121]   I
    Structure Of Cyp121, A Mycobacterial P450, In Complex With Iodopyrazole.

1n6b <PDB>   [Oxidoreductase | P450 2C5]   I
    Microsomal Cytochrome P450 2C5/3Lvdh Complex With A Dimethyl Derivative Of Sulfaphenazole.

1n97 (Chain A) <PDB>   [Electron Transport | CYP175A1]   I
    Crystal Stucture Of Cyp175A1 From Thermus Thermophillus Strain Hb27.

1noo#   <PDB>   [Oxidoreductase (Oxygenase) | P450cam]   I
    Cytochrome P450Cam Complexed With 5-Exo-Hydroxycamphor.

1nr6 <PDB>   [Oxidoreductase | P450 2C5]   I
    Microsomal Cytochrome P450 2C5/3Lvdh Complex With Diclofenac.

1o76 (Chain A)  <PDB>   [Oxidoreductase | P450cam | camphor | cyanide ion]   I
    Cyanide Complex Of P450Cam From Pseudomonas Putida.

1odo   <PDB>   [Oxidoreductase | CYP154A1 | 4-phenyl-1H-imidazole]   I
    1.85 A Structure Of Cyp154A1 From Streptomyces Coelicolor A3(2).

1og2 (Chain A)  <PDB>   [Electron Transport | P450 2C9]   I
    Structure Of Human Cytochrome P450 Cyp2C9.

1og5 (Chain A)  <PDB>   [Electron Transport | P450 2C9]   I
    Structure Of Human Cytochrome P450 Cyp2C9.

1oxa   <PDB>   [Oxidoreductase (Oxygenase) | P450eryF | erythromycin]   I   I'(33)   P(70)
    Cytochrome P450 (Donor: O2 Oxidoreductase).

1p0v (Chain A)  <PDB>   [Oxidoreductase | P450BM3]   I
    F393A Mutant Heme Domain Of Flavocytochrome P450 Bm3.

1p0w (Chain A)  <PDB>   [Oxidoreductase | P450BM3]   I
    F393W Mutant Heme Domain Of Flavocytochrome P450 Bm3.

1p0x (Chain A)  <PDB>   [Oxidoreductase | P450BM3]   I
    F393Y Mutant Heme Domain Of Flavocytochrome P450 Bm3.

1p2y   <PDB>   [Oxidoreductase | P450cam]   I
    Crystal Structure Of Cytochrome P450Cam In Complex With (S)- (-)-Nicotine.

1p7r   <PDB>   [Oxidoreductase | P450cam]   I
    Crystal Structure Of Reduced, Co-Exposed Complex Of Cytochrome P450Cam With (S)- (-)-Nicotine.

1pha   <PDB>   [Oxidoreductase(Oxygenase) | P450cam | 1-(N-imidazolyl)-2-hydroxy-2-(2,3-dichlorophenyl)octane]   I
    Inhibitor-induced conformational change in cytochrome P-450CAM.

1phb   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Inhibitor-induced conformational change in cytochrome P-450CAM.

1phc   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structure of substrate-free Pseudomonas putida cytochrome P-450.

1phd   <PDB>   [Oxidoreductase(Oxygenase) | P450cam | 2-phenylimidazole]   I
    Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam.

1phe   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam.

1phf   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam.

1phg   <PDB>   [Oxidoreductase(Oxygenase) | P450cam]   I
    Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam.

1po5   <PDB>   [Oxidoreductase | P450 2B4]   I(35)
    Structure Of Mammalian Cytochrome P450 2B4.

1pq2 (Chain A) <PDB>   [Oxidoreductase | P450 2C8]   I
    Crystal Structure Of Human Drug Metabolizing Cytochrome P450 2C8.

1q5d <PDB>   [Oxidoreductase | P450epok]   I
    Epothilone B-Bound Cytochrome P450Epok.

1q5e <PDB>   [Oxidoreductase | P450epok]   I
    Substrate-Free Cytochrome P450Epok.

1qmq*   <PDB>   [Oxidoreductase | P450cam]   I
    Optical Detection Of Cytochrome P450 By Sensitizer-Linked Substrates.

1r9o   <PDB>   [Oxidoreductase | P450 2C9 | flurbiprofen | glycerol]   I
    Crystal Structure Of P4502C9 With Flurbiprofen Bound.

1rom   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structure Of Nitric Reductase From Denitrifying Fungus Fusarium Oxysporum.

2rom   <PDB>   [Oxidoreductase | P450nor]   I
    Crystal Structure Of Nitric Reductase From Denitrifying Fungus Fusarium Oxysporum Complex With Carbon Monoxide.

1smi (Chain A)  <PDB>   [Oxidoreductase | P450 102 | P450BM3]   I
    A Single Mutation Of P450 Bm3 Induces The Conformational Rearrangement Seen Upon Substrate-Binding In Wild-Type Enzyme.

1smj (Chain A)  <PDB>   [Oxidoreductase | P450 102 | P450BM3 | palmitoleic acid]   I
    Structure Of The A264E Mutant Of Cytochrome P450 Bm3 Complexed With Palmitoleate.

1suo   <PDB>   [Oxidoreductase | P450 2B4]   I
    Structure Of Mammalian Cytochrome P450 2B4 With Bound 4-(4- Chlorophenyl)Imidazole.

1tqn   <PDB>   [Oxidoreductase | P450 3A4]   I
    Crystal Structure Of Human Microsomal P450 3A4.

1ue8   <PDB>   [Unknown Function | P450 | chloride ion]   I
    Crystal Structure Of Thermophilic Cytochrome P450 From Sulfolobus Tokodaii.

1ued (Chain A)  <PDB>   [Oxidoreductase | P450 Oxyc]   I
    Crystal Structure Of Oxyc A Cytochrome P450 Implicated In An Oxidative C-C Coupling Reaction During Vancomycin Biosynthesis.

1w0e   <PDB>   [Oxidoreductase | P450 3A4]   I
    Crystal Structure Of Human Cytochrome P450 3A4.

1w0f   <PDB>   [Oxidoreductase | P450 3A4 | progesterone]   I
    Crystal Structure Of Human Cytochrome P450 3A4.

1w0g   <PDB>   [Oxidoreductase | P450 3A4 | metyrapone]   I
    Crystal Structure Of Human Cytochrome P450 3A4.

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  • 'Amino' colors
      ASP  GLU  CYS  MET  LYS  ARG  SER  THR  PHE  TYR  ASN  GLN  GLY  LEU  VAL  ILE  ALA  TRP  HIS  PRO

    -- See Amino Acid Properties --
  • Acidic, Neutral [Aromatic], Basic
      ASP  GLU  GLY  ALA  VAL  LEU  ILE  CYS  SER  THR  ASN  GLN  PRO  MET  PHE  TYR  TRP  LYS  ARG  HIS
  • Polar [Acidic, Basic], Nonpolar (Hydrophobic) 
      SER  THR  TYR  CYS  ASN  GLN  ASP  GLU  LYS  ARG  HIS  GLY  ALA  VAL  LEU  ILE  PHE  PRO  MET  TRP
  • Hydropathy Index
      ARG  LYS  ASN  ASP  GLN  GLU  HIS  PRO  TYR  TRP  SER  THR  GLY  ALA  MET  CYS  PHE  LEU  VAL  ILE
  • I/O
      ASN  SER  ASP  GLN  GLU  THR  ARG  HIS  GLY  LYS  TYR  TRP  CYS  MET  PRO  PHE  ALA  VAL  LEU  ILE
  • pI
      ASP  GLU  CYS  ASN  PHE  GLN  TYR  SER  MET  TRP  VAL  GLY  LEU  ALA  ILE  THR  PRO  HIS  LYS  ARG
















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