![]() ※本文文献番号と図の参照ページ:[1],[2],[3],[4-5],[6],[7]・図4(本ページ),[8]・図5 | 図1,図2,図3 ![]() 同誌目次に掲載の画像(辰年に昇龍をイメージして。本ページTLR3から作成) 本ページについて日本コンピュータ化学会2012春季年会(2012/05/17-18,東京工業大学大岡山キャンパス)で発表しました(要旨PDF参照可)。 本ページは審良静男研究室 監修・坂野上淳 著,「新しい自然免疫学 ―免疫システムの真の主役」,技術評論社(2010)を参考に作成を始めたものです。同書によれば自然免疫で重要な役割をしていることがわかってきたToll様受容体は,ヒトでは10種類が知られています。今後少しずつデータを追加していく予定です。 |
Toll様受容体(TLRs)が認識する病原体成分
TLR | 認識される主な病原体成分 |
---|---|
TLR1 + TLR2 | リボタンパク質 |
TLR2 | ペプチドグリカン |
TLR3 | ウイルスの2本鎖RNA |
TLR4 | リポ多糖(LPS) |
TLR5 | フラジェリン(フラゲリン, 鞭毛の構成タンパク質) |
TLR6 + TLR2 | リポタンパク質 |
TLR7 | ウイルスの1本鎖RNA |
TLR8 | ウイルスの1本鎖RNA |
TLR9 | 細菌やウイルスのDNA〔CG(CpG)配列〕 ※ヒトなど哺乳類では同配列中のCの多くがメチル化され区別 |
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2Z7X(TLR1/TLR2)A鎖(TLR2)選択 B鎖(TLR1)選択 C鎖(トリアシル化リポペプチドPam2CSK4)選択 PCJ(同脂質部分)選択 同PDBsumデータ2z7x_PCJ$ 6NIGのChain C・D(TLR2;Diprovocimが結合) KQD(Diprovocim)選択 同PDBsumデータ6nig_KQD$ 6NIH(TLR1) バックボーン 二次構造 全選択 タンパク質選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
$ “BCAA球表示(Leu Ile Val)”は以下のアミノ酸配列表と同色で50%球表示になります。表示変更後は3種のアミノ酸残基が選択された状態になっていますので,球サイズ変更やアミノ色指定(この場合は全アミノ酸が対応色に)などが可能です(以下同)。
Ser | Leu | Ser | Cys | Asp | Arg | Asn | Gly | Ile | Cys | Lys | Gly | Ser | Ser | Gly | Ser | Leu | Asn | Ser | Ile | Pro | Ser | Gly | Leu | Thr |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glu | Ala | Val | Lys | Ser | Leu | Asp | Leu | Ser | Asn | Asn | Arg | Ile | Thr | Tyr | Ile | Ser | Asn | Ser | Asp | Leu | Gln | Arg | Cys | Val |
Asn | Leu | Gln | Ala | Leu | Val | Leu | Thr | Ser | Asn | Gly | Ile | Asn | Thr | Ile | Glu | Glu | Asp | Ser | Phe | Ser | Ser | Leu | Gly | Ser |
Leu | Glu | His | Leu | Asp | Leu | Ser | Tyr | Asn | Tyr | Leu | Ser | Asn | Leu | Ser | Ser | Ser | Trp | Phe | Lys | Pro | Leu | Ser | Ser | Leu |
Thr | Phe | Leu | Asn | Leu | Leu | Gly | Asn | Pro | Tyr | Lys | Thr | Leu | Gly | Glu | Thr | Ser | Leu | Phe | Ser | His | Leu | Thr | Lys | Leu |
Gln | Ile | Leu | Arg | Val | Gly | Asn | Met | Asp | Thr | Phe | Thr | Lys | Ile | Gln | Arg | Lys | Asp | Phe | Ala | Gly | Leu | Thr | Phe | Leu |
Glu | Glu | Leu | Glu | Ile | Asp | Ala | Ser | Asp | Leu | Gln | Ser | Tyr | Glu | Pro | Lys | Ser | Leu | Lys | Ser | Ile | Gln | Asn | Val | Ser |
His | Leu | Ile | Leu | His | Met | Lys | Gln | His | Ile | Leu | Leu | Leu | Glu | Ile | Phe | Val | Asp | Val | Thr | Ser | Ser | Val | Glu | Cys |
Leu | Glu | Leu | Arg | Asp | Thr | Asp | Leu | Asp | Thr | Phe | His | Phe | Ser | Glu | Leu | Ser | Thr | Gly | Glu | Thr | Asn | Ser | Leu | Ile |
Lys | Lys | Phe | Thr | Phe | Arg | Asn | Val | Lys | Ile | Thr | Asp | Glu | Ser | Leu | Phe | Gln | Val | Met | Lys | Leu | Leu | Asn | Gln | Ile |
Ser | Gly | Leu | Leu | Glu | Leu | Glu | Phe | Asp | Asp | Cys | Thr | Leu | Asn | Gly | Val | Gly | Asn | Phe | Arg | Ala | Ser | Asp | Asn | Asp |
Arg | Val | Ile | Asp | Pro | Gly | Lys | Val | Glu | Thr | Leu | Thr | Ile | Arg | Arg | Leu | His | Ile | Pro | Arg | Phe | Tyr | Leu | Phe | Tyr |
Asp | Leu | Ser | Thr | Leu | Tyr | Ser | Leu | Thr | Glu | Arg | Val | Lys | Arg | Ile | Thr | Val | Glu | Asn | Ser | Lys | Val | Phe | Leu | Val |
Pro | Cys | Leu | Leu | Ser | Gln | His | Leu | Lys | Ser | Leu | Glu | Tyr | Leu | Asp | Leu | Ser | Glu | Asn | Leu | Met | Val | Glu | Glu | Tyr |
Leu | Lys | Asn | Ser | Ala | Cys | Glu | Asp | Ala | Trp | Pro | Ser | Leu | Gln | Thr | Leu | Ile | Leu | Arg | Gln | Asn | His | Leu | Ala | Ser |
Leu | Glu | Lys | Thr | Gly | Glu | Thr | Leu | Leu | Thr | Leu | Lys | Asn | Leu | Thr | Asn | Ile | Asp | Ile | Ser | Lys | Asn | Ser | Phe | His |
Ser | Met | Pro | Glu | Thr | Cys | Gln | Trp | Pro | Glu | Lys | Met | Lys | Tyr | Leu | Asn | Leu | Ser | Ser | Thr | Arg | Ile | His | Ser | Val |
Thr | Gly | Cys | Ile | Pro | Lys | Thr | Leu | Glu | Ile | Leu | Asp | Val | Ser | Asn | Asn | Asn | Leu | Asn | Leu | Phe | Ser | Leu | Asn | Leu |
Pro | Gln | Leu | Lys | Glu | Leu | Tyr | Ile | Ser | Arg | Asn | Lys | Leu | Met | Thr | Leu | Pro | Asp | Ala | Ser | Leu | Leu | Pro | Met | Leu |
Leu | Val | Leu | Lys | Ile | Ser | Arg | Asn | Gln | Leu | Lys | Ser | Val | Pro | Asp | Gly | Ile | Phe | Asp | Arg | Leu | Thr | Ser | Leu | Gln |
Lys | Ile | Trp | Leu | His | Thr | Asn | Pro | Trp | Asp | Cys | Ser | Cys | Pro | Arg | Ile | Asp | Tyr | Leu | Ser | Arg | Trp | Leu | Asn | Lys |
Asn | Ser | Gln | Lys | Glu | Gln | Gly | Ser | Ala | Lys | Cys | Ser | Gly | Ser | Gly | Lys | Pro | Val | Arg | Ser | Ile | Ile | Cys | Pro |
2Z7X B鎖(TLR1)のアミノ酸配列
Ser | Glu | Phe | Leu | Val | Asp | Arg | Ser | Lys | Asn | Gly | Leu | Ile | His | Val | Pro | Lys | Asp | Leu | Ser | Gln | Lys | Thr | Thr | Ile |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leu | Asn | Ile | Ser | Gln | Asn | Tyr | Ile | Ser | Glu | Leu | Trp | Thr | Ser | Asp | Ile | Leu | Ser | Leu | Ser | Lys | Leu | Arg | Ile | Leu |
Ile | Ile | Ser | His | Asn | Arg | Ile | Gln | Tyr | Leu | Asp | Ile | Ser | Val | Phe | Lys | Phe | Asn | Gln | Glu | Leu | Glu | Tyr | Leu | Asp |
Leu | Ser | His | Asn | Lys | Leu | Val | Lys | Ile | Ser | Cys | His | Pro | Thr | Val | Asn | Leu | Lys | His | Leu | Asp | Leu | Ser | Phe | Asn |
Ala | Phe | Asp | Ala | Leu | Pro | Ile | Cys | Lys | Glu | Phe | Gly | Asn | Met | Ser | Gln | Leu | Lys | Phe | Leu | Gly | Leu | Ser | Thr | Thr |
His | Leu | Glu | Lys | Ser | Ser | Val | Leu | Pro | Ile | Ala | His | Leu | Asn | Ile | Ser | Lys | Val | Leu | Leu | Val | Leu | Gly | Glu | Thr |
Tyr | Gly | Glu | Lys | Glu | Asp | Pro | Glu | Gly | Leu | Gln | Asp | Phe | Asn | Thr | Glu | Ser | Leu | His | Ile | Val | Phe | Pro | Thr | Asn |
Lys | Glu | Phe | His | Phe | Ile | Leu | Asp | Val | Ser | Val | Lys | Thr | Val | Ala | Asn | Leu | Glu | Leu | Ser | Asn | Ile | Lys | Cys | Val |
Leu | Glu | Asp | Asn | Lys | Cys | Ser | Tyr | Phe | Leu | Ser | Ile | Leu | Ala | Lys | Leu | Gln | Thr | Asn | Pro | Lys | Leu | Ser | Asn | Leu |
Thr | Leu | Asn | Asn | Ile | Glu | Thr | Thr | Trp | Asn | Ser | Phe | Ile | Arg | Ile | Leu | Gln | Leu | Val | Trp | His | Thr | Thr | Val | Trp |
Tyr | Phe | Ser | Ile | Ser | Asn | Val | Lys | Leu | Gln | Gly | Gln | Leu | Asp | Phe | Arg | Asp | Phe | Asp | Tyr | Ser | Gly | Thr | Ser | Leu |
Lys | Ala | Leu | Ser | Ile | His | Gln | Val | Val | Ser | Asp | Val | Phe | Gly | Phe | Pro | Gln | Ser | Tyr | Ile | Tyr | Glu | Ile | Phe | Ser |
Asn | Met | Asn | Ile | Lys | Asn | Phe | Thr | Val | Ser | Gly | Thr | Arg | Met | Val | His | Met | Leu | Cys | Pro | Ser | Lys | Ile | Ser | Pro |
Phe | Leu | His | Leu | Asp | Phe | Ser | Asn | Asn | Leu | Leu | Thr | Asp | Thr | Val | Phe | Glu | Asn | Cys | Gly | His | Leu | Thr | Glu | Leu |
Glu | Thr | Leu | Ile | Leu | Gln | Met | Asn | Gln | Leu | Lys | Glu | Leu | Ser | Lys | Ile | Ala | Glu | Met | Thr | Thr | Gln | Met | Lys | Ser |
Leu | Gln | Gln | Leu | Asp | Ile | Ser | Gln | Asn | Ser | Val | Ser | Tyr | Asp | Glu | Lys | Lys | Gly | Asp | Cys | Ser | Trp | Thr | Lys | Ser |
Leu | Leu | Ser | Leu | Asn | Met | Ser | Ser | Asn | Ile | Leu | Thr | Asp | Thr | Ile | Phe | Arg | Cys | Leu | Pro | Pro | Arg | Ile | Lys | Val |
Leu | Asp | Leu | His | Ser | Asn | Lys | Ile | Lys | Ser | Ile | Pro | Lys | Gln | Val | Val | Lys | Leu | Glu | Ala | Leu | Gln | Glu | Leu | Asn |
Val | Ala | Ser | Asn | Gln | Leu | Lys | Ser | Val | Pro | Asp | Gly | Ile | Phe | Asp | Arg | Leu | Thr | Ser | Leu | Gln | Lys | Ile | Trp | Leu |
His | Thr | Asn | Pro | Trp | Asp | Cys | Ser | Cys | Pro | Arg | Ile | Asp | Tyr | Leu | Ser | Arg | Trp | Leu | Asn | Lys | Asn | Ser | Gln | Lys |
Glu | Gln | Gly | Ser | Ala | Lys | Cys | Ser | Gly | Ser | Gly | Lys | Pro | Val | Arg | Ser | Ile | Ile | Cys | Pro |
Met | Thr | Ser | Ile | Phe | His | Phe | Ala | Ile | Ile | Phe | Met | Leu | Ile | Leu | Gln | Ile | Arg | Ile | Gln | Leu | Ser | Glu | Glu | Ser |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glu | Phe | Leu | Val | Asp | Arg | Ser | Lys | Asn | Gly | Leu | Ile | His | Val | Pro | Lys | Asp | Leu | Ser | Gln | Lys | Thr | Thr | Ile | Leu |
Asn | Ile | Ser | Gln | Asn | Tyr | Ile | Ser | Glu | Leu | Trp | Thr | Ser | Asp | Ile | Leu | Ser | Leu | Ser | Lys | Leu | Arg | Ile | Leu | Ile |
Ile | Ser | His | Asn | Arg | Ile | Gln | Tyr | Leu | Asp | Ile | Ser | Val | Phe | Lys | Phe | Asn | Gln | Glu | Leu | Glu | Tyr | Leu | Asp | Leu |
Ser | His | Asn | Lys | Leu | Val | Lys | Ile | Ser | Cys | His | Pro | Thr | Val | Asn | Leu | Lys | His | Leu | Asp | Leu | Ser | Phe | Asn | Ala |
Phe | Asp | Ala | Leu | Pro | Ile | Cys | Lys | Glu | Phe | Gly | Asn | Met | Ser | Gln | Leu | Lys | Phe | Leu | Gly | Leu | Ser | Thr | Thr | His |
Leu | Glu | Lys | Ser | Ser | Val | Leu | Pro | Ile | Ala | His | Leu | Asn | Ile | Ser | Lys | Val | Leu | Leu | Val | Leu | Gly | Glu | Thr | Tyr |
Gly | Glu | Lys | Glu | Asp | Pro | Glu | Gly | Leu | Gln | Asp | Phe | Asn | Thr | Glu | Ser | Leu | His | Ile | Val | Phe | Pro | Thr | Asn | Lys |
Glu | Phe | His | Phe | Ile | Leu | Asp | Val | Ser | Val | Lys | Thr | Val | Ala | Asn | Leu | Glu | Leu | Ser | Asn | Ile | Lys | Cys | Val | Leu |
Glu | Asp | Asn | Lys | Cys | Ser | Tyr | Phe | Leu | Ser | Ile | Leu | Ala | Lys | Leu | Gln | Thr | Asn | Pro | Lys | Leu | Ser | Asn | Leu | Thr |
Leu | Asn | Asn | Ile | Glu | Thr | Thr | Trp | Asn | Ser | Phe | Ile | Arg | Ile | Leu | Gln | Leu | Val | Trp | His | Thr | Thr | Val | Trp | Tyr |
Phe | Ser | Ile | Ser | Asn | Val | Lys | Leu | Gln | Gly | Gln | Leu | Asp | Phe | Arg | Asp | Phe | Asp | Tyr | Ser | Gly | Thr | Ser | Leu | Lys |
Ala | Leu | Ser | Ile | His | Gln | Val | Val | Ser | Asp | Val | Phe | Gly | Phe | Pro | Gln | Ser | Tyr | Ile | Tyr | Glu | Ile | Phe | Ser | Asn |
Met | Asn | Ile | Lys | Asn | Phe | Thr | Val | Ser | Gly | Thr | Arg | Met | Val | His | Met | Leu | Cys | Pro | Ser | Lys | Ile | Ser | Pro | Phe |
Leu | His | Leu | Asp | Phe | Ser | Asn | Asn | Leu | Leu | Thr | Asp | Thr | Val | Phe | Glu | Asn | Cys | Gly | His | Leu | Thr | Glu | Leu | Glu |
Thr | Leu | Ile | Leu | Gln | Met | Asn | Gln | Leu | Lys | Glu | Leu | Ser | Lys | Ile | Ala | Glu | Met | Thr | Thr | Gln | Met | Lys | Ser | Leu |
Gln | Gln | Leu | Asp | Ile | Ser | Gln | Asn | Ser | Val | Ser | Tyr | Asp | Glu | Lys | Lys | Gly | Asp | Cys | Ser | Trp | Thr | Lys | Ser | Leu |
Leu | Ser | Leu | Asn | Met | Ser | Ser | Asn | Ile | Leu | Thr | Asp | Thr | Ile | Phe | Arg | Cys | Leu | Pro | Pro | Arg | Ile | Lys | Val | Leu |
Asp | Leu | His | Ser | Asn | Lys | Ile | Lys | Ser | Ile | Pro | Lys | Gln | Val | Val | Lys | Leu | Glu | Ala | Leu | Gln | Glu | Leu | Asn | Val |
Ala | Ser | Asn | Gln | Leu | Lys | Ser | Val | Pro | Asp | Gly | Ile | Phe | Asp | Arg | Leu | Thr | Ser | Leu | Gln | Lys | Ile | Trp | Leu | His |
Thr | Asn | Pro | Trp | Asp | Cys | Ser | Cys | Pro | Arg | Ile | Asp | Tyr | Leu | Ser | Arg | Trp | Leu | Asn | Lys | Asn | Ser | Gln | Lys | Glu |
Gln | Gly | Ser | Ala | Lys | Cys | Ser | Gly | Ser | Gly | Lys | Pro | Val | Arg | Ser | Ile | Ile | Cys | Pro | Thr |
Met | Thr | Ser | Ile | Phe | His | Phe | Ala | Ile | Ile | Phe | Met | Leu | Ile | Leu | Gln | Ile | Arg | Ile | Gln | Leu | Ser | Glu | Glu | Ser |
Glu | Phe | Leu | Val | Asp | Arg | Ser | Lys | Asn | Gly | Leu | Ile | His | Val | Pro | Lys | Asp | Leu | Ser | Gln | Lys | Thr | Thr | Ile | Leu |
Asn | Ile | Ser | Gln | Asn | Tyr | Ile | Ser | Glu | Leu | Trp | Thr | Ser | Asp | Ile | Leu | Ser | Leu | Ser | Lys | Leu | Arg | Ile | Leu | Ile |
Ile | Ser | His | Asn | Arg | Ile | Gln | Tyr | Leu | Asp | Ile | Ser | Val | Phe | Lys | Phe | Asn | Gln | Glu | Leu | Glu | Tyr | Leu | Asp | Leu |
Ser | His | Asn | Lys | Leu | Val | Lys | Ile | Ser | Cys | His | Pro | Thr | Val | Asn | Leu | Lys | His | Leu | Asp | Leu | Ser | Phe | Asn | Ala |
Phe | Asp | Ala | Leu | Pro | Ile | Cys | Lys | Glu | Phe | Gly | Asn | Met | Ser | Gln | Leu | Lys | Phe | Leu | Gly | Leu | Ser | Thr | Thr | His |
Leu | Glu | Lys | Ser | Ser | Val | Leu | Pro | Ile | Ala | His | Leu | Asn | Ile | Ser | Lys | Val | Leu | Leu | Val | Leu | Gly | Glu | Thr | Tyr |
Gly | Glu | Lys | Glu | Asp | Pro | Glu | Gly | Leu | Gln | Asp | Phe | Asn | Thr | Glu | Ser | Leu | His | Ile | Val | Phe | Pro | Thr | Asn | Lys |
Glu | Phe | His | Phe | Ile | Leu | Asp | Val | Ser | Val | Lys | Thr | Val | Ala | Asn | Leu | Glu | Leu | Ser | Asn | Ile | Lys | Cys | Val | Leu |
Glu | Asp | Asn | Lys | Cys | Ser | Tyr | Phe | Leu | Ser | Ile | Leu | Ala | Lys | Leu | Gln | Thr | Asn | Pro | Lys | Leu | Ser | Asn | Leu | Thr |
Leu | Asn | Asn | Ile | Glu | Thr | Thr | Trp | Asn | Ser | Phe | Ile | Arg | Ile | Leu | Gln | Leu | Val | Trp | His | Thr | Thr | Val | Trp | Tyr |
Phe | Ser | Ile | Ser | Asn | Val | Lys | Leu | Gln | Gly | Gln | Leu | Asp | Phe | Arg | Asp | Phe | Asp | Tyr | Ser | Gly | Thr | Ser | Leu | Lys |
Ala | Leu | Ser | Ile | His | Gln | Val | Val | Ser | Asp | Val | Phe | Gly | Phe | Pro | Gln | Ser | Tyr | Ile | Tyr | Glu | Ile | Phe | Ser | Asn |
Met | Asn | Ile | Lys | Asn | Phe | Thr | Val | Ser | Gly | Thr | Arg | Met | Val | His | Met | Leu | Cys | Pro | Ser | Lys | Ile | Ser | Pro | Phe |
Leu | His | Leu | Asp | Phe | Ser | Asn | Asn | Leu | Leu | Thr | Asp | Thr | Val | Phe | Glu | Asn | Cys | Gly | His | Leu | Thr | Glu | Leu | Glu |
Thr | Leu | Ile | Leu | Gln | Met | Asn | Gln | Leu | Lys | Glu | Leu | Ser | Lys | Ile | Ala | Glu | Met | Thr | Thr | Gln | Met | Lys | Ser | Leu |
Gln | Gln | Leu | Asp | Ile | Ser | Gln | Asn | Ser | Val | Ser | Tyr | Asp | Glu | Lys | Lys | Gly | Asp | Cys | Ser | Trp | Thr | Lys | Ser | Leu |
Leu | Ser | Leu | Asn | Met | Ser | Ser | Asn | Ile | Leu | Thr | Asp | Thr | Ile | Phe | Arg | Cys | Leu | Pro | Pro | Arg | Ile | Lys | Val | Leu |
Asp | Leu | His | Ser | Asn | Lys | Ile | Lys | Ser | Ile | Pro | Lys | Gln | Val | Val | Lys | Leu | Glu | Ala | Leu | Gln | Glu | Leu | Asn | Val |
Ala | Ser | Asn | Gln | Leu | Lys | Ser | Val | Pro | Asp | Gly | Ile | Phe | Asp | Arg | Leu | Thr | Ser | Leu | Gln | Lys | Ile | Trp | Leu | His |
Thr | Asn | Pro | Trp | Asp | Cys | Ser | Cys | Pro | Arg | Ile | Asp | Tyr | Leu | Ser | Arg | Trp | Leu | Asn | Lys | Asn | Ser | Gln | Lys | Glu |
Gln | Gly | Ser | Ala | Lys | Cys | Ser | Gly | Ser | Gly | Lys | Pro | Val | Arg | Ser | Ile | Ile | Cys | Pro | Thr |
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3ciy 同PDBsumデータ3ciy_gly06(糖鎖NDG-NAG-MAN-MAN-MANのSITE;RNA含む) I'/O'=4.500 ※一部原子が表示されません(今後修正) 7c76(Unc93B1が結合) B鎖(Unc93B1)選択 →東京大学プレスリリース(2021/01/12) [UNC93B1 - Wikipedia] 7wm4のChain A・B・D・E(Chain A・BがdsRNA) →横浜市立大学プレスリリース(2023/01/17) 8yhu(minibinder 8.6が結合) minibinder 8.6(Chain B)のTyr30・Tyr33・Ala34・Val43・Leu47・Val51選択 →Nature Communications論文(2025/01/31) バックボーン 二次構造 DNA/RNA(ATGCU,backbone) 全選択 タンパク質選択 DNA/RNA選択 同backbone選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
2本鎖RNAを含むToll様受容体TLR3の構造例,PDBデータ3ciy(中はロイシンを強調表示,右はJmolトピックス参照〈クリックで拡大〉)
Gln | Cys | Thr | Val | Arg | Tyr | Asn | Val | Ala | Asp | Cys | Ser | His | Leu | Lys | Leu | Thr | His | Ile | Pro | Asp | Asp | Leu | Pro | Ser |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Asn | Ile | Thr | Val | Leu | Asn | Leu | Thr | His | Asn | Gln | Leu | Arg | Arg | Leu | Pro | Pro | Thr | Asn | Phe | Thr | Arg | Tyr | Ser | Gln |
Leu | Ala | Ile | Leu | Asp | Ala | Gly | Phe | Asn | Ser | Ile | Ser | Lys | Leu | Glu | Pro | Glu | Leu | Cys | Gln | Ile | Leu | Pro | Leu | Leu |
Lys | Val | Leu | Asn | Leu | Gln | His | Asn | Glu | Leu | Ser | Gln | Ile | Ser | Asp | Gln | Thr | Phe | Val | Phe | Cys | Thr | Asn | Leu | Thr |
Glu | Leu | Asp | Leu | Met | Ser | Asn | Ser | Ile | His | Lys | Ile | Lys | Ser | Asn | Pro | Phe | Lys | Asn | Gln | Lys | Asn | Leu | Ile | Lys |
Leu | Asp | Leu | Ser | His | Asn | Gly | Leu | Ser | Ser | Thr | Lys | Leu | Gly | Thr | Gly | Val | Gln | Leu | Glu | Asn | Leu | Gln | Glu | Leu |
Leu | Leu | Ala | Lys | Asn | Lys | Ile | Leu | Ala | Leu | Arg | Ser | Glu | Glu | Leu | Glu | Phe | Leu | Gly | Asn | Ser | Ser | Leu | Arg | Lys |
Leu | Asp | Leu | Ser | Ser | Asn | Pro | Leu | Lys | Glu | Phe | Ser | Pro | Gly | Cys | Phe | Gln | Thr | Ile | Gly | Lys | Leu | Phe | Ala | Leu |
Leu | Leu | Asn | Asn | Ala | Gln | Leu | Asn | Pro | His | Leu | Thr | Glu | Lys | Leu | Cys | Trp | Glu | Leu | Ser | Asn | Thr | Ser | Ile | Gln |
Asn | Leu | Ser | Leu | Ala | Asn | Asn | Gln | Leu | Leu | Ala | Thr | Ser | Glu | Ser | Thr | Phe | Ser | Gly | Leu | Lys | Trp | Thr | Asn | Leu |
Thr | Gln | Leu | Asp | Leu | Ser | Tyr | Asn | Asn | Leu | His | Asp | Val | Gly | Asn | Gly | Ser | Phe | Ser | Tyr | Leu | Pro | Ser | Leu | Arg |
Tyr | Leu | Ser | Leu | Glu | Tyr | Asn | Asn | Ile | Gln | Arg | Leu | Ser | Pro | Arg | Ser | Phe | Tyr | Gly | Leu | Ser | Asn | Leu | Arg | Tyr |
Leu | Ser | Leu | Lys | Arg | Ala | Phe | Thr | Lys | Gln | Ser | Val | Ser | Leu | Ala | Ser | His | Pro | Asn | Ile | Asp | Asp | Phe | Ser | Phe |
Gln | Trp | Leu | Lys | Tyr | Leu | Glu | Tyr | Leu | Asn | Met | Asp | Asp | Asn | Asn | Ile | Pro | Ser | Thr | Lys | Ser | Asn | Thr | Phe | Thr |
Gly | Leu | Val | Ser | Leu | Lys | Tyr | Leu | Ser | Leu | Ser | Lys | Thr | Phe | Thr | Ser | Leu | Gln | Thr | Leu | Thr | Asn | Glu | Thr | Phe |
Val | Ser | Leu | Ala | His | Ser | Pro | Leu | Leu | Thr | Leu | Asn | Leu | Thr | Lys | Asn | His | Ile | Ser | Lys | Ile | Ala | Asn | Gly | Thr |
Phe | Ser | Trp | Leu | Gly | Gln | Leu | Arg | Ile | Leu | Asp | Leu | Gly | Leu | Asn | Glu | Ile | Glu | Gln | Lys | Leu | Ser | Gly | Gln | Glu |
Trp | Arg | Gly | Leu | Arg | Asn | Ile | Phe | Glu | Ile | Tyr | Leu | Ser | Tyr | Asn | Lys | Tyr | Leu | Gln | Leu | Ser | Thr | Ser | Ser | Phe |
Ala | Leu | Val | Pro | Ser | Leu | Gln | Arg | Leu | Met | Leu | Arg | Arg | Val | Ala | Leu | Lys | Asn | Val | Asp | Ile | Ser | Pro | Ser | Pro |
Phe | Arg | Pro | Leu | Arg | Asn | Leu | Thr | Ile | Leu | Asp | Leu | Ser | Asn | Asn | Asn | Ile | Ala | Asn | Ile | Asn | Glu | Asp | Leu | Leu |
Glu | Gly | Leu | Glu | Asn | Leu | Glu | Ile | Leu | Asp | Phe | Gln | His | Asn | Asn | Leu | Ala | Arg | Leu | Trp | Lys | Arg | Ala | Asn | Pro |
Gly | Gly | Pro | Val | Asn | Phe | Leu | Lys | Gly | Leu | Ser | His | Leu | His | Ile | Leu | Asn | Leu | Glu | Ser | Asn | Gly | Leu | Asp | Glu |
Ile | Pro | Val | Gly | Val | Phe | Lys | Asn | Leu | Phe | Glu | Leu | Lys | Ser | Ile | Asn | Leu | Gly | Leu | Asn | Asn | Leu | Asn | Lys | Leu |
Glu | Pro | Phe | Ile | Phe | Asp | Asp | Gln | Thr | Ser | Leu | Arg | Ser | Leu | Asn | Leu | Gln | Lys | Asn | Leu | Ile | Thr | Ser | Val | Glu |
Lys | Asp | Val | Phe | Gly | Pro | Pro | Phe | Gln | Asn | Leu | Asn | Ser | Leu | Asp | Met | Arg | Phe | Asn | Pro | Phe | Asp | Cys | Thr | Cys |
Glu | Ser | Ile | Ser | Trp | Phe | Val | Asn | Trp | Ile | Asn | Gln | Thr | His | Thr | Asn | Ile | Ser | Glu | Leu | Ser | Thr | His | Tyr | Leu |
Cys | Asn | Thr | Pro | His | His | Tyr | Tyr | Gly | Phe | Pro | Leu | Lys | Leu | Phe | Asp | Thr | Ser | Ser | Cys | Lys | Asp | Ser | Ala | Pro |
Phe | Glu | Asn | Leu | Tyr | Phe | Gln | Gly | His | His | His | His | His | His | Trp | Ser | His | Pro | Gln | Phe | Glu | Lys |
7wm4のChain A・B・D・E(Chain A・BがdsRNA,Chain C・Fは省略)とその部分拡大図(横浜市立大学プレスリリース(2023/01/17)図1最下図参照)
→ Nature Communications誌論文(2023/01/11)
8yhuとその部分拡大図(紫四角はminibinder 8.6のTyr30・Tyr33・Ala34・Val43・Leu47・Val51)
→ Nature Communications論文(2025/01/31)のFig. 3
|
3FXI(MD-2タンパク質とともにリポ多糖に結合) 同PDBsumデータ3fxi_lps01(リポ多糖 PA1 1001(A) to PO4 1018(A)) I'/O'=0.669 3ULA(リンパ球抗原96〈MD-2〉とエリトランが結合) 同PDBsumデータ3ula_E55(エリトラン) I'/O'=0.436 5HG4(MD-2と活性化剤neoseptin-3が結合;現在5IJCに更新) neoseptin-3選択 同PDBsumデータ5hg4_61S[709(A)](活性化剤neoseptin-3) I'/O'=0.267 → Newswiseニュース 5IJD(MD-2とリピドAが結合;5HG6から更新) LP4とLP5選択 → Newswiseニュース 7MLM(MD-2が結合) → PNAS論文 8WTAのChain A・C(Chain CがMD-2) バックボーン 二次構造 全選択 タンパク質選択 A・B鎖(TLR4)選択 C-D鎖(MD-2〈リンパ球抗原96〉)選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
Glu | Pro | Cys | Val | Glu | Val | Val | Pro | Asn | Ile | Thr | Tyr | Gln | Cys | Met | Glu | Leu | Asn | Phe | Tyr | Lys | Ile | Pro | Asp | Asn |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leu | Pro | Phe | Ser | Thr | Lys | Asn | Leu | Asp | Leu | Ser | Phe | Asn | Pro | Leu | Arg | His | Leu | Gly | Ser | Tyr | Ser | Phe | Phe | Ser |
Phe | Pro | Glu | Leu | Gln | Val | Leu | Asp | Leu | Ser | Arg | Cys | Glu | Ile | Gln | Thr | Ile | Glu | Asp | Gly | Ala | Tyr | Gln | Ser | Leu |
Ser | His | Leu | Ser | Thr | Leu | Ile | Leu | Thr | Gly | Asn | Pro | Ile | Gln | Ser | Leu | Ala | Leu | Gly | Ala | Phe | Ser | Gly | Leu | Ser |
Ser | Leu | Gln | Lys | Leu | Val | Ala | Val | Glu | Thr | Asn | Leu | Ala | Ser | Leu | Glu | Asn | Phe | Pro | Ile | Gly | His | Leu | Lys | Thr |
Leu | Lys | Glu | Leu | Asn | Val | Ala | His | Asn | Leu | Ile | Gln | Ser | Phe | Lys | Leu | Pro | Glu | Tyr | Phe | Ser | Asn | Leu | Thr | Asn |
Leu | Glu | His | Leu | Asp | Leu | Ser | Ser | Asn | Lys | Ile | Gln | Ser | Ile | Tyr | Cys | Thr | Asp | Leu | Arg | Val | Leu | His | Gln | Met |
Pro | Leu | Leu | Asn | Leu | Ser | Leu | Asp | Leu | Ser | Leu | Asn | Pro | Met | Asn | Phe | Ile | Gln | Pro | Gly | Ala | Phe | Lys | Glu | Ile |
Arg | Leu | His | Lys | Leu | Thr | Leu | Arg | Asn | Asn | Phe | Asp | Ser | Leu | Asn | Val | Met | Lys | Thr | Cys | Ile | Gln | Gly | Leu | Ala |
Gly | Leu | Glu | Val | His | Arg | Leu | Val | Leu | Gly | Glu | Phe | Arg | Asn | Glu | Gly | Asn | Leu | Glu | Lys | Phe | Asp | Lys | Ser | Ala |
Leu | Glu | Gly | Leu | Cys | Asn | Leu | Thr | Ile | Glu | Glu | Phe | Arg | Leu | Ala | Tyr | Leu | Asp | Tyr | Tyr | Leu | Asp | Asp | Ile | Ile |
Asp | Leu | Phe | Asn | Cys | Leu | Thr | Asn | Val | Ser | Ser | Phe | Ser | Leu | Val | Ser | Val | Thr | Ile | Glu | Arg | Val | Lys | Asp | Phe |
Ser | Tyr | Asn | Phe | Gly | Trp | Gln | His | Leu | Glu | Leu | Val | Asn | Cys | Lys | Phe | Gly | Gln | Phe | Pro | Thr | Leu | Lys | Leu | Lys |
Ser | Leu | Lys | Arg | Leu | Thr | Phe | Thr | Ser | Asn | Lys | Gly | Gly | Asn | Ala | Phe | Ser | Glu | Val | Asp | Leu | Pro | Ser | Leu | Glu |
Phe | Leu | Asp | Leu | Ser | Arg | Asn | Gly | Leu | Ser | Phe | Lys | Gly | Cys | Cys | Ser | Gln | Ser | Asp | Phe | Gly | Thr | Thr | Ser | Leu |
Lys | Tyr | Leu | Asp | Leu | Ser | Phe | Asn | Gly | Val | Ile | Thr | Met | Ser | Ser | Asn | Phe | Leu | Gly | Leu | Glu | Gln | Leu | Glu | His |
Leu | Asp | Phe | Gln | His | Ser | Asn | Leu | Lys | Gln | Met | Ser | Glu | Phe | Ser | Val | Phe | Leu | Ser | Leu | Arg | Asn | Leu | Ile | Tyr |
Leu | Asp | Ile | Ser | His | Thr | His | Thr | Arg | Val | Ala | Phe | Asn | Gly | Ile | Phe | Asn | Gly | Leu | Ser | Ser | Leu | Glu | Val | Leu |
Lys | Met | Ala | Gly | Asn | Ser | Phe | Gln | Glu | Asn | Phe | Leu | Pro | Asp | Ile | Phe | Thr | Glu | Leu | Arg | Asn | Leu | Thr | Phe | Leu |
Asp | Leu | Ser | Gln | Cys | Gln | Leu | Glu | Gln | Leu | Ser | Pro | Thr | Ala | Phe | Asn | Ser | Leu | Ser | Ser | Leu | Gln | Val | Leu | Asn |
Met | Ser | His | Asn | Asn | Phe | Phe | Ser | Leu | Asp | Thr | Phe | Pro | Tyr | Lys | Cys | Leu | Asn | Ser | Leu | Gln | Val | Leu | Asp | Tyr |
Ser | Leu | Asn | His | Ile | Met | Thr | Ser | Lys | Lys | Gln | Glu | Leu | Gln | His | Phe | Pro | Ser | Ser | Leu | Ala | Phe | Leu | Asn | Leu |
Thr | Gln | Asn | Asp | Phe | Ala | Cys | Thr | Cys | Glu | His | Gln | Ser | Phe | Leu | Gln | Trp | Ile | Lys | Asp | Gln | Arg | Gln | Leu | Leu |
Val | Glu | Val | Glu | Arg | Met | Glu | Cys | Ala | Thr | Pro | Ser | Asp | Lys | Gln | Gly | Met | Pro | Val | Leu | Ser | Leu | Asn | Ile | Thr |
Cys | Gln | Met | Asn | Lys |
3FXIのPDBsumデータ
エリトラン(eritoran)が結合したTLR4 3ULAとPDBsumデータ → 新型コロナウイルス(SARS-CoV-2|COVID-19)情報
Gly | Ser | Glu | Pro | Cys | Val | Glu | Val | Val | Pro | Asn | Ile | Thr | Tyr | Gln | Cys | Met | Glu | Leu | Asn | Phe | Tyr | Lys | Ile | Pro |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Asp | Asn | Leu | Pro | Phe | Ser | Thr | Lys | Asn | Leu | Asp | Leu | Ser | Trp | Asn | Pro | Leu | Arg | His | Leu | Gly | Ser | Tyr | Ser | Phe |
Phe | Ser | Phe | Pro | Glu | Leu | Gln | Val | Leu | Asp | Leu | Ser | Arg | Cys | Glu | Ile | Gln | Thr | Ile | Glu | Asp | Gly | Ala | Tyr | Gln |
Ser | Leu | Ser | His | Leu | Ser | Thr | Leu | Ile | Leu | Thr | Gly | Asn | Pro | Ile | Gln | Ser | Leu | Ala | Leu | Gly | Ala | Phe | Ser | Gly |
Leu | Ser | Ser | Leu | Gln | Lys | Leu | Val | Ala | Val | Glu | Thr | Asn | Leu | Ala | Ser | Leu | Glu | Asn | Phe | Pro | Ile | Gly | His | Leu |
Lys | Thr | Leu | Lys | Glu | Leu | Asn | Val | Ala | His | Asn | Leu | Ile | Gln | Ser | Phe | Lys | Leu | Pro | Glu | Tyr | Phe | Ser | Asn | Leu |
Thr | Asn | Leu | Glu | His | Leu | Asp | Leu | Ser | Ser | Asn | Lys | Ile | Gln | Ser | Ile | Tyr | Cys | Thr | Asp | Leu | Arg | Val | Leu | His |
Gln | Met | Pro | Leu | Leu | Asn | Leu | Ser | Leu | Asp | Leu | Ser | Leu | Asn | Pro | Met | Asn | Phe | Ile | Gln | Pro | Gly | Ala | Phe | Lys |
Glu | Ile | Arg | Leu | Lys | Glu | Leu | Ala | Leu | Asp | Thr | Asn | Gln | Leu | Lys | Ser | Val | Pro | Asp | Gly | Ile | Phe | Asp | Arg | Leu |
Thr | Ser | Leu | Gln | Lys | Ile | Trp | Leu | His | Thr | Asn | Pro | Trp | Asp | Cys | Ser | Cys | Pro | Arg | Ile | Asp | Tyr | Leu | Ser | Arg |
Trp | Leu | Asn | Lys | Asn | Ser | Gln | Lys | Glu | Gln | Gly | Ser | Ala | Lys | Cys | Ser | Gly | Ser | Gly | Lys | Pro | Val | Arg | Ser | Ile |
Ile | Cys | Pro | Thr |
|
3J0A(TLR5の相同性モデル;フラジェリン非結合) 3V47(フラジェリンが結合) 5GY2(フラジェリンが結合) 6BXC(VLR9〈可変性リンパ球受容体9〉が結合;他にVLR2結合の6BXAあり) [Variable lymphocyte receptor - Wikipedia] バックボーン 二次構造 全選択 タンパク質選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
Ser | Cys | Ser | Phe | Asp | Gly | Arg | Ile | Ala | Phe | Tyr | Arg | Phe | Cys | Asn | Leu | Thr | Gln | Val | Pro | Gln | Val | Leu | Asn | Thr |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thr | Glu | Arg | Leu | Leu | Leu | Ser | Phe | Asn | Tyr | Ile | Arg | Thr | Val | Thr | Ala | Ser | Ser | Phe | Pro | Phe | Leu | Glu | Gln | Leu |
Gln | Leu | Leu | Glu | Leu | Gly | Ser | Gln | Tyr | Thr | Pro | Leu | Thr | Ile | Asp | Lys | Glu | Ala | Phe | Arg | Asn | Leu | Pro | Asn | Leu |
Arg | Ile | Leu | Asp | Leu | Gly | Ser | Ser | Lys | Ile | Tyr | Phe | Leu | His | Pro | Asp | Ala | Phe | Gln | Gly | Leu | Phe | His | Leu | Phe |
Glu | Leu | Arg | Leu | Tyr | Phe | Cys | Gly | Leu | Ser | Asp | Ala | Val | Leu | Lys | Asp | Gly | Tyr | Phe | Arg | Asn | Leu | Lys | Ala | Leu |
Thr | Arg | Leu | Asp | Leu | Ser | Lys | Asn | Gln | Ile | Arg | Ser | Leu | Tyr | Leu | His | Pro | Ser | Phe | Gly | Lys | Leu | Asn | Ser | Leu |
Lys | Ser | Ile | Asp | Phe | Ser | Ser | Asn | Gln | Ile | Phe | Leu | Val | Cys | Glu | His | Glu | Leu | Glu | Pro | Leu | Gln | Gly | Lys | Thr |
Leu | Ser | Phe | Phe | Ser | Leu | Ala | Ala | Asn | Ser | Leu | Tyr | Ser | Arg | Val | Ser | Val | Asp | Trp | Gly | Lys | Cys | Met | Asn | Pro |
Phe | Arg | Asn | Met | Val | Leu | Glu | Ile | Leu | Asp | Val | Ser | Gly | Asn | Gly | Trp | Thr | Val | Asp | Ile | Thr | Gly | Asn | Phe | Ser |
Asn | Ala | Ile | Ser | Lys | Ser | Gln | Ala | Phe | Ser | Leu | Ile | Leu | Ala | His | His | Ile | Met | Gly | Ala | Gly | Phe | Gly | Phe | His |
Asn | Ile | Lys | Asp | Pro | Asp | Gln | Asn | Thr | Phe | Ala | Gly | Leu | Ala | Arg | Ser | Ser | Val | Arg | His | Leu | Asp | Leu | Ser | His |
Gly | Phe | Val | Phe | Ser | Leu | Asn | Ser | Arg | Val | Phe | Glu | Thr | Leu | Lys | Asp | Leu | Lys | Val | Leu | Asn | Leu | Ala | Tyr | Asn |
Lys | Ile | Asn | Lys | Ile | Ala | Asp | Glu | Ala | Phe | Tyr | Gly | Leu | Asp | Asn | Leu | Gln | Val | Leu | Asn | Leu | Ser | Tyr | Asn | Leu |
Leu | Gly | Glu | Leu | Tyr | Ser | Ser | Asn | Phe | Tyr | Gly | Leu | Pro | Lys | Val | Ala | Tyr | Ile | Asp | Leu | Gln | Lys | Asn | His | Ile |
Ala | Ile | Ile | Gln | Asp | Gln | Thr | Phe | Lys | Phe | Leu | Glu | Lys | Leu | Gln | Thr | Leu | Asp | Leu | Arg | Asp | Asn | Ala | Leu | Thr |
Thr | Ile | His | Phe | Ile | Pro | Ser | Ile | Pro | Asp | Ile | Phe | Leu | Ser | Gly | Asn | Lys | Leu | Val | Thr | Leu | Pro | Lys | Ile | Asn |
Leu | Thr | Ala | Asn | Leu | Ile | His | Leu | Ser | Glu | Asn | Arg | Leu | Glu | Asn | Leu | Asp | Ile | Leu | Tyr | Phe | Leu | Leu | Arg | Val |
Pro | His | Leu | Gln | Ile | Leu | Ile | Leu | Asn | Gln | Asn | Arg | Phe | Ser | Ser | Cys | Ser | Gly | Asp | Gln | Thr | Pro | Ser | Glu | Asn |
Pro | Ser | Leu | Glu | Gln | Leu | Phe | Leu | Gly | Glu | Asn | Met | Leu | Gln | Leu | Ala | Trp | Glu | Thr | Glu | Leu | Cys | Trp | Asp | Val |
Phe | Glu | Gly | Leu | Ser | His | Leu | Gln | Val | Leu | Tyr | Leu | Asn | His | Asn | Tyr | Leu | Asn | Ser | Leu | Pro | Pro | Gly | Val | Phe |
Ser | His | Leu | Thr | Ala | Leu | Arg | Gly | Leu | Ser | Leu | Asn | Ser | Asn | Arg | Leu | Thr | Val | Leu | Ser | His | Asn | Asp | Leu | Pro |
Ala | Asn | Leu | Glu | Ile | Leu | Asp | Ile | Ser | Arg | Asn | Gln | Leu | Leu | Ala | Pro | Asn | Pro | Asp | Val | Phe | Val | Ser | Leu | Ser |
Val | Leu | Asp | Ile | Thr | His | Asn | Lys | Phe | Ile | Cys | Glu | Cys | Glu | Leu | Ser | Thr | Phe | Ile | Asn | Trp | Leu | Asn | His | Thr |
Asn | Val | Thr | Ile | Ala | Gly | Pro | Pro | Ala | Asp | Ile | Tyr | Cys | Val | Tyr | Pro | Asp | Ser | Phe | Ser | Gly | Val | Ser | Leu | Phe |
Ser | Leu | Ser | Thr | Glu | Gly | Cys | Asp | Glu | Glu | Glu | Val | Leu | Lys | Ser | Leu | Lys | Phe | Ser | Leu | Phe | Ile | Val | Cys | Thr |
Val | Thr | Leu | Thr | Leu | Phe | Leu | Met | Thr | Ile | Leu | Thr | Val | Thr | Lys | Phe | Arg | Gly | Phe | Cys | Phe | Ile | Cys | Tyr | Lys |
Thr | Ala | Gln | Arg | Leu | Val | Phe | Lys | Asp | His | Pro | Gln | Gly | Thr | Glu | Pro | Asp | Met | Tyr | Lys | Tyr | Asp | Ala | Tyr | Leu |
Cys | Phe | Ser | Ser | Lys | Asp | Phe | Thr | Trp | Val | Gln | Asn | Ala | Leu | Leu | Lys | His | Leu | Asp | Thr | Gln | Tyr | Ser | Asp | Gln |
Asn | Arg | Phe | Asn | Leu | Cys | Phe | Glu | Glu | Arg | Asp | Phe | Val | Pro | Gly | Glu | Asn | Arg | Ile | Ala | Asn | Ile | Gln | Asp | Ala |
Ile | Trp | Asn | Ser | Arg | Lys | Ile | Val | Cys | Leu | Val | Ser | Arg | His | Phe | Leu | Arg | Asp | Gly | Trp | Cys | Leu | Glu | Ala | Phe |
Ser | Tyr | Ala | Gln | Gly | Arg | Cys | Leu | Ser | Asp | Leu | Asn | Ser | Ala | Leu | Ile | Met | Val | Val | Val | Gly | Ser | Leu | Ser | Gln |
Tyr | Gln | Leu | Met | Lys | His | Gln | Ser | Ile | Arg | Gly | Phe | Val | Gln | Lys | Gln | Gln | Tyr | Leu | Arg | Trp | Pro | Glu | Asp | Phe |
Gln | Asp | Val | Gly | Trp | Phe | Leu | His | Lys | Leu | Ser | Gln | Gln | Ile | Leu | Lys | Lys | Glu | Lys | Glu | Lys | Lys | Lys | Asp | Asn |
Asn | Ile | Pro | Leu | Gln | Thr | Val | Ala | Thr | Ile | Ser | Gly | Ser | His | His | His | His | His | His |
Ala | Asp | Pro | Gly | Thr | Ser | Glu | Cys | Ser | Val | Ile | Gly | Tyr | Asn | Ala | Ile | Cys | Ile | Asn | Arg | Gly | Leu | His | Gln | Val |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pro | Glu | Leu | Pro | Ala | His | Val | Asn | Tyr | Val | Asp | Leu | Ser | Leu | Asn | Ser | Ile | Ala | Glu | Leu | Asn | Glu | Thr | Ser | Phe |
Ser | Arg | Leu | Gln | Asp | Leu | Gln | Phe | Leu | Lys | Val | Glu | Gln | Gln | Thr | Pro | Gly | Leu | Val | Ile | Arg | Asn | Asn | Thr | Phe |
Arg | Gly | Leu | Ser | Ser | Leu | Ile | Ile | Leu | Lys | Leu | Asp | Tyr | Asn | Gln | Phe | Leu | Gln | Leu | Glu | Thr | Gly | Ala | Phe | Asn |
Gly | Leu | Ala | Asn | Leu | Glu | Val | Leu | Thr | Leu | Thr | Gln | Cys | Asn | Leu | Asp | Gly | Ala | Val | Leu | Ser | Gly | Asn | Phe | Phe |
Lys | Pro | Leu | Thr | Ser | Leu | Glu | Met | Leu | Val | Leu | Arg | Asp | Asn | Asn | Ile | Lys | Lys | Ile | Gln | Pro | Ala | Ser | Phe | Phe |
Leu | Asn | Met | Arg | Arg | Phe | His | Val | Leu | Asp | Leu | Thr | Phe | Asn | Lys | Val | Lys | Ser | Ile | Cys | Glu | Glu | Asp | Leu | Leu |
Asn | Phe | Gln | Gly | Lys | His | Phe | Thr | Leu | Leu | Arg | Leu | Ser | Ser | Ile | Thr | Leu | Gln | Asp | Met | Asn | Glu | Tyr | Trp | Leu |
Gly | Trp | Glu | Lys | Cys | Gly | Asn | Pro | Phe | Lys | Asn | Thr | Ser | Ile | Thr | Thr | Leu | Asp | Leu | Ser | Gly | Asn | Gly | Phe | Lys |
Glu | Ser | Met | Ala | Lys | Arg | Phe | Phe | Asp | Ala | Ile | Ala | Gly | Thr | Lys | Ile | Gln | Ser | Leu | Ile | Leu | Ser | Asn | Ser | Tyr |
Asn | Met | Gly | Ser | Ser | Phe | Gly | His | Thr | Asn | Phe | Lys | Asp | Pro | Asp | Asn | Phe | Thr | Phe | Lys | Gly | Leu | Glu | Ala | Ser |
Gly | Val | Lys | Thr | Cys | Asp | Leu | Ser | Lys | Ser | Lys | Ile | Phe | Ala | Leu | Leu | Lys | Ser | Val | Phe | Ser | His | Phe | Thr | Asp |
Leu | Glu | Gln | Leu | Thr | Leu | Ala | Gln | Asn | Glu | Ile | Asn | Lys | Ile | Asp | Asp | Asn | Ala | Phe | Trp | Gly | Leu | Thr | His | Leu |
Leu | Lys | Leu | Asn | Leu | Ser | Gln | Asn | Phe | Leu | Gly | Ser | Ile | Asp | Ser | Arg | Met | Phe | Glu | Asn | Leu | Asp | Lys | Leu | Glu |
Val | Leu | Asp | Leu | Ser | Tyr | Asn | His | Ile | Arg | Ala | Leu | Gly | Asp | Gln | Ser | Phe | Leu | Gly | Leu | Pro | Asn | Leu | Lys | Glu |
Leu | Ala | Leu | Asp | Thr | Asn | Gln | Leu | Lys | Ser | Val | Pro | Asp | Gly | Ile | Phe | Asp | Arg | Leu | Thr | Ser | Leu | Gln | Lys | Ile |
Trp | Leu | His | Thr | Asn | Pro | Trp | Asp | Cys | Ser | Cys | Pro | Arg | Ile | Asp | Tyr | Leu | Ser | Arg | Trp | Leu | Asn | Lys | Asn | Ser |
Gln | Lys | Glu | Gln | Gly | Ser | Ala | Lys | Cys | Ser | Gly | Ser | Gly | Lys | Pro | Val | Arg | Ser | Ile | Ile | Cys | Pro | Thr | Ser | Ala |
Ser | Leu | Val | Pro | Arg |
|
バックボーン 二次構造 全選択 タンパク質選択 A鎖(TLR2)選択 B鎖(TLR6)選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
Met | Ser | Gln | Asp | Arg | Lys | Pro | Ile | Val | Gly | Ser | Phe | His | Phe | Val | Cys | Ala | Leu | Ala | Leu | Ile | Val | Gly | Ser | Met |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thr | Pro | Phe | Ser | Asn | Glu | Leu | Glu | Ser | Met | Val | Asp | Tyr | Ser | Asn | Arg | Asn | Leu | Thr | His | Val | Pro | Lys | Asp | Leu |
Pro | Pro | Arg | Thr | Lys | Ala | Leu | Ser | Leu | Ser | Gln | Asn | Ser | Ile | Ser | Glu | Leu | Arg | Met | Pro | Asp | Ile | Ser | Phe | Leu |
Ser | Glu | Leu | Arg | Val | Leu | Arg | Leu | Ser | His | Asn | Arg | Ile | Arg | Ser | Leu | Asp | Phe | His | Val | Phe | Leu | Phe | Asn | Gln |
Asp | Leu | Glu | Tyr | Leu | Asp | Val | Ser | His | Asn | Arg | Leu | Gln | Asn | Ile | Ser | Cys | Cys | Pro | Met | Ala | Ser | Leu | Arg | His |
Leu | Asp | Leu | Ser | Phe | Asn | Asp | Phe | Asp | Val | Leu | Pro | Val | Cys | Lys | Glu | Phe | Gly | Asn | Leu | Thr | Lys | Leu | Thr | Phe |
Leu | Gly | Leu | Ser | Ala | Ala | Lys | Phe | Arg | Gln | Leu | Asp | Leu | Leu | Pro | Val | Ala | His | Leu | His | Leu | Ser | Cys | Ile | Leu |
Leu | Asp | Leu | Val | Ser | Tyr | His | Ile | Lys | Gly | Gly | Glu | Thr | Glu | Ser | Leu | Gln | Ile | Pro | Asn | Thr | Thr | Val | Leu | His |
Leu | Val | Phe | His | Pro | Asn | Ser | Leu | Phe | Ser | Val | Gln | Val | Asn | Met | Ser | Val | Asn | Ala | Leu | Gly | His | Leu | Gln | Leu |
Ser | Asn | Ile | Lys | Leu | Asn | Asp | Glu | Asn | Cys | Gln | Arg | Leu | Met | Thr | Phe | Leu | Ser | Glu | Leu | Thr | Arg | Gly | Pro | Thr |
Leu | Leu | Asn | Val | Thr | Leu | Gln | His | Ile | Glu | Thr | Thr | Trp | Lys | Cys | Ser | Val | Lys | Leu | Phe | Gln | Phe | Phe | Trp | Pro |
Arg | Pro | Val | Glu | Tyr | Leu | Asn | Ile | Tyr | Asn | Leu | Thr | Ile | Thr | Glu | Arg | Ile | Asp | Arg | Glu | Glu | Phe | Thr | Tyr | Ser |
Glu | Thr | Ala | Leu | Lys | Ser | Leu | Met | Ile | Glu | His | Val | Lys | Asn | Gln | Val | Phe | Leu | Phe | Ser | Lys | Glu | Ala | Leu | Tyr |
Ser | Val | Phe | Ala | Glu | Met | Asn | Ile | Lys | Met | Leu | Ser | Ile | Ser | Asp | Thr | Pro | Phe | Ile | His | Met | Val | Cys | Pro | Pro |
Ser | Pro | Ser | Ser | Phe | Thr | Phe | Leu | Asn | Phe | Thr | Gln | Asn | Val | Phe | Thr | Asp | Ser | Val | Phe | Gln | Gly | Cys | Ser | Thr |
Leu | Lys | Arg | Leu | Gln | Thr | Leu | Ile | Leu | Gln | Arg | Asn | Gly | Leu | Lys | Asn | Phe | Phe | Lys | Val | Ala | Leu | Met | Thr | Lys |
Asn | Met | Ser | Ser | Leu | Glu | Thr | Leu | Asp | Val | Ser | Leu | Asn | Ser | Leu | Asn | Ser | His | Ala | Tyr | Asp | Arg | Thr | Cys | Ala |
Trp | Ala | Glu | Ser | Ile | Leu | Val | Leu | Asn | Leu | Ser | Ser | Asn | Met | Leu | Thr | Gly | Ser | Val | Phe | Arg | Cys | Leu | Pro | Pro |
Lys | Val | Lys | Val | Leu | Asp | Leu | His | Asn | Asn | Arg | Ile | Met | Ser | Ile | Pro | Lys | Asp | Val | Thr | His | Leu | Gln | Ala | Leu |
Gln | Glu | Leu | Asn | Val | Ala | Ser | Asn | Gln | Leu | Lys | Ser | Val | Pro | Asp | Gly | Val | Phe | Asp | Arg | Leu | Thr | Ser | Leu | Gln |
Tyr | Ile | Trp | Leu | His | Asp | Asn | Pro | Trp | Asp | Cys | Thr | Cys | Pro | Gly | Ile | Arg | Tyr | Leu | Ser | Glu | Trp | Ile | Asn | Lys |
His | Ser | Gly | Val | Val | Arg | Asn | Ser | Ala | Gly | Ser | Val | Ala | Pro | Asp | Ser | Ala | Lys | Cys | Ser | Gly | Ser | Gly | Lys | Pro |
Val | Arg | Ser | Ile | Ile | Cys | Pro | Thr | Leu | Val | Pro | Arg |
|
5GMG(TLR7活性化ロキソリビンとpolyUが結合) 同PDBsumデータ5gmg_SDL[Chain B]$ 5GMH(TLR7活性化R848が結合) 同PDBsumデータ5gmh_RX8[Chain A]$ 5ZSA(アゴニストIMDQとUUUUUU結合) IDQ(IMDQ)選択 同PDBsumデータ5zsa_IDQ$ | PDBsumデータ5zsf_6T0$ PDBsumデータ5zsg_9K3$ PDBsumデータ5zsh_L07$ PDBsumデータ5zsi_C09$ PDBsumデータ5zsj_9JR$ PDBsumデータ6if5_23G$ 6LW1(“Cpd-7”が結合) 7cynのChain A・C(Unc93B1が結合) C鎖(Unc93B1)選択 → 東京大学プレスリリース(2021/01/12) [UNC93B1 - Wikipedia] 7YTPのChain A(阻害剤E6742が結合) 同PDBsumデータ7ytp_lp$ 8i96のChain B(TH-407bが結合) 同PDBsumデータ8i96_lp$ 8ttzのChain A(compound 20が結合) QCX(compound 20)選択 同PDBsumデータ8ttz_lp$ → ACS Medicinal Chemistry Letters誌論文(2024/01/08) 9mhvのChain A(agonist 9が結合) 同PDBsumデータ9mhv_lp$ → ACS Medicinal Chemistry Letters誌論文(2024/12/18) バックボーン 二次構造 DNA/RNA(ATGCU,backbone) 全選択 タンパク質選択 DNA/RNA選択 同backbone選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
Arg | Ser | Pro | Trp | Ala | Arg | Trp | Phe | Pro | Lys | Thr | Leu | Pro | Cys | Asp | Val | Thr | Leu | Asp | Val | Ser | Lys | Asn | His | Val |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ile | Val | Asp | Cys | Thr | Asp | Lys | His | Leu | Thr | Glu | Ile | Pro | Gly | Gly | Ile | Pro | Thr | Asn | Thr | Thr | Asn | Leu | Thr | Leu |
Thr | Ile | Asn | His | Ile | Pro | Asp | Ile | Ser | Pro | Ala | Ser | Phe | His | Arg | Leu | Val | His | Leu | Val | Glu | Ile | Asp | Phe | Arg |
Cys | Asn | Cys | Val | Pro | Ile | Arg | Leu | Gly | Ser | Lys | Ser | Asn | Met | Cys | Pro | Arg | Arg | Leu | Gln | Ile | Lys | Pro | Arg | Ser |
Phe | Ser | Gly | Leu | Thr | Tyr | Leu | Lys | Ser | Leu | Tyr | Leu | Asp | Gly | Asn | Gln | Leu | Leu | Glu | Ile | Pro | Gln | Gly | Leu | Pro |
Pro | Ser | Leu | Gln | Leu | Leu | Ser | Leu | Glu | Ala | Asn | Asn | Ile | Phe | Ser | Ile | Arg | Lys | Glu | Gln | Leu | Thr | Glu | Leu | Ala |
Asn | Ile | Glu | Ile | Leu | Tyr | Leu | Gly | Gln | Asn | Cys | Tyr | Tyr | Arg | Asn | Pro | Cys | Tyr | Val | Ser | Tyr | Ser | Ile | Glu | Lys |
Asp | Ala | Phe | Leu | Asn | Leu | Thr | Lys | Leu | Lys | Val | Leu | Ser | Leu | Lys | Asp | Asn | Asn | Val | Thr | Thr | Val | Pro | Thr | Val |
Leu | Pro | Ser | Thr | Leu | Thr | Glu | Leu | Tyr | Leu | Tyr | Asn | Asn | Met | Ile | Ala | Glu | Ile | Gln | Glu | Asp | Asp | Phe | Asn | Asn |
Leu | Asn | Gln | Leu | Gln | Ile | Leu | Asp | Leu | Ser | Gly | Asn | Cys | Pro | Arg | Cys | Tyr | Asn | Ala | Pro | Phe | Pro | Cys | Thr | Pro |
Cys | Lys | Asn | Asn | Ser | Pro | Leu | Gln | Ile | Pro | Val | Asn | Ala | Phe | Asp | Ala | Leu | Thr | Glu | Leu | Lys | Val | Leu | Arg | Leu |
His | Ser | Asn | Ser | Leu | Gln | His | Val | Pro | Pro | Arg | Trp | Phe | Lys | Asn | Ile | Asn | Asn | Leu | Gln | Glu | Leu | Asp | Leu | Ser |
Gln | Asn | Phe | Leu | Ala | Lys | Glu | Ile | Gly | Asp | Ala | Lys | Phe | Leu | His | Phe | Leu | Pro | Asn | Leu | Ile | Gln | Leu | Asp | Leu |
Ser | Phe | Asn | Phe | Glu | Leu | Gln | Val | Tyr | Arg | Ala | Ser | Met | Asn | Leu | Ser | Gln | Ala | Phe | Ser | Ser | Leu | Lys | Ser | Leu |
Lys | Ile | Leu | Arg | Ile | Arg | Gly | Tyr | Val | Phe | Lys | Glu | Leu | Lys | Ser | Phe | Gln | Leu | Ser | Pro | Leu | His | Asn | Leu | Gln |
Asn | Leu | Glu | Val | Leu | Asp | Leu | Gly | Thr | Asn | Phe | Ile | Lys | Ile | Ala | Asn | Leu | Ser | Met | Phe | Lys | Gln | Phe | Lys | Arg |
Leu | Lys | Val | Ile | Asp | Leu | Ser | Val | Asn | Lys | Ile | Ser | Pro | Ser | Gly | Asp | Ser | Ser | Glu | Val | Gly | Phe | Cys | Ser | Asn |
Ala | Arg | Thr | Ser | Val | Glu | Ser | Tyr | Glu | Pro | Gln | Val | Leu | Glu | Gln | Leu | Tyr | Tyr | Phe | Arg | Tyr | Asp | Lys | Tyr | Ala |
Arg | Ser | Cys | Arg | Phe | Lys | Asn | Lys | Glu | Ala | Ser | Phe | Thr | Ser | Val | Gln | Glu | Ser | Cys | Tyr | Lys | Tyr | Gly | Gln | Thr |
Leu | Asp | Leu | Ser | Lys | Asn | Ser | Ile | Phe | Phe | Ile | Lys | Ser | Ser | Asp | Phe | Gln | His | Leu | Ser | Phe | Leu | Lys | Cys | Leu |
Asn | Leu | Ser | Gly | Asn | Leu | Ile | Ser | Gln | Thr | Leu | Asn | Gly | Ser | Glu | Phe | Gln | Pro | Leu | Ala | Glu | Leu | Arg | Tyr | Leu |
Asp | Phe | Ser | Asn | Asn | Arg | Leu | Asp | Leu | Leu | His | Ser | Thr | Ala | Phe | Glu | Glu | Leu | Arg | Lys | Leu | Glu | Val | Leu | Asp |
Ile | Ser | Ser | Asn | Ser | His | Tyr | Phe | Gln | Ser | Glu | Gly | Ile | Thr | His | Met | Leu | Asn | Phe | Thr | Lys | Asn | Leu | Lys | Val |
Leu | Gln | Lys | Leu | Met | Met | Asn | Asp | Asn | Asp | Ile | Ser | Ser | Ser | Thr | Ser | Arg | Thr | Met | Glu | Ser | Glu | Ser | Leu | Arg |
Thr | Leu | Glu | Phe | Arg | Gly | Asn | His | Leu | Asp | Val | Leu | Trp | Arg | Asp | Gly | Asp | Asn | Arg | Tyr | Leu | Gln | Leu | Phe | Lys |
Asn | Leu | Leu | Lys | Leu | Glu | Glu | Leu | Asp | Ile | Ser | Lys | Asn | Ser | Leu | Ser | Phe | Leu | Pro | Ser | Gly | Val | Phe | Asp | Gly |
Met | Pro | Pro | Asn | Leu | Lys | Asn | Leu | Ser | Leu | Ala | Lys | Asn | Gly | Leu | Lys | Ser | Phe | Ile | Trp | Glu | Lys | Leu | Arg | Tyr |
Leu | Lys | Asn | Leu | Glu | Thr | Leu | Asp | Leu | Ser | His | Asn | Gln | Leu | Thr | Thr | Val | Pro | Glu | Arg | Leu | Ser | Asn | Cys | Ser |
Arg | Ser | Leu | Lys | Asn | Leu | Ile | Leu | Lys | Asn | Asn | Gln | Ile | Arg | Ser | Leu | Thr | Lys | Tyr | Phe | Leu | Gln | Asp | Ala | Phe |
Gln | Leu | Arg | Tyr | Leu | Asp | Leu | Ser | Ser | Asn | Lys | Ile | Gln | Met | Ile | Gln | Lys | Thr | Ser | Phe | Pro | Glu | Asn | Val | Leu |
Asn | Asn | Leu | Lys | Met | Leu | Leu | Leu | His | His | Asn | Arg | Phe | Leu | Cys | Thr | Cys | Asp | Ala | Val | Trp | Phe | Val | Trp | Trp |
Val | Gln | His | Thr | Glu | Val | Thr | Ile | Pro | Tyr | Leu | Ala | Thr | Asp | Val | Thr | Cys | Val | Gly | Pro | Gly | Ala | His | Lys | Gly |
Gln | Ser | Val | Ile | Ser | Leu | Asp | Leu | Tyr | Thr | Cys | Glu | Leu | Asp | Leu | Thr | Asn |
5ZSA,5ZSF,5ZSG,5ZSH,5ZSI,5ZSJ,6IF5のPDBsumデータ
[左]7YTPのChain A(阻害剤E6742が結合)とPDBsumデータ
[右]8I96のChain B(TH-407bが結合)とPDBsumデータ
[左]8TTZのChain A(compound 20が結合)とPDBsumデータ
[右]9MHVのChain A(agonist 9が結合)とPDBsumデータ
|
3W3J(低分子リガンドCL097を含む) 同PDBsumデータ3w3j_C09[Chain A]$ 4QC0(低分子リガンドXG-1-236を含む) 同PDBsumデータ4qc0_XG1[Chain A]$ 5AWA(MB-568が結合) 同PDBsumデータ5awa_M8D[Chain A]$ | 5AWCのChain A・B(MB-564が結合) 同PDBsumデータ5awc_M4D[Chain A]$ 5AZ5のChain A・B(MB-343が結合) 同PDBsumデータ5az5_MBL[Chain A]$ 5HDH 同PDBsumデータ5hdh_MES$ → PNAS論文(2016/02/29) 5WYX(CU-CPT8mが結合) 同PDBsumデータ5wyx_CU8[Chain A]$ | 5WYZ(CU-CPT9b結合) 同PDBsumデータ5wyz_7VF[Chain A]$ 5Z14(CU-CPT9aが結合) 同PDBsumデータ5z14_7VC[Chain A]$ | 5Z15(CU-CPT9c結合) 同PDBsumデータ5z15_7VL[Chain A]$ 6TY5 O0W(compound 11)選択 同PDBsumデータ6ty5_O0W[Chain B]$ → Journal of Medicinal Chemistry論文 6V9U QSM(antagonist 14c)選択 同PDBsumデータ6v9u_QSM[Chain A]$ → Journal of Medicinal Chemistry論文 6zjz QLH(M5049)選択 同PDBsumデータ6zjz_QLH$ → Journal of Pharmacology and Experimental Therapeutics論文 6wmlのChain A U57(GS-9688〈セルガントリモド,selgantolimod〉)選択 同PDBsumデータ6wml_U57[1017(A)]$ → Journal of Medicinal Chemistry論文 7crf GD0(CU-CPD107)選択 同PDBsumデータ7crf_GD0$ 7r53のChain A(アンタゴニストcompound 15が結合) 同PDBsumデータ7r53_I5N$ | PDBsumデータ7r52_I6A(compound 2)$ PDBsumデータ7r54_I5B(compound 4)$ → ACS Medicinal Chemistry Letters論文 7rc9のChain A(アンタゴニストcompound 21〈BMS-905〉が結合) RQY(BMS-905)選択 PDBsumデータ7rc9A_lp$ → ACS Medicinal Chemistry Letters論文 7ytxのChain A(アンタゴニストE6742が結合) JRI(E6742)選択 PDBsumデータ7ytxA_JRI$ → European Journal of Pharmacology論文 8pfiのChain A(アンタゴニストMHV370が結合) YHG(MHV370)選択 PDBsumデータ8pfiA_lp[907(A)]$ → ACS Medicinal Chemistry Letters論文 バックボーン 二次構造 全選択 タンパク質選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
3W3Jと4QC0,およびそれぞれのPDBsumデータ
※参考:自然免疫における核酸センサーTLR8のリガンド認識および活性化機構の解明 -抗ウイルス薬、がん免疫賦活剤の開発に道-(SPring-8,2013/03/22)
Arg | Ser | Pro | Trp | Glu | Glu | Asn | Phe | Ser | Arg | Ser | Tyr | Pro | Cys | Asp | Glu | Lys | Lys | Gln | Asn | Asp | Ser | Val | Ile | Ala |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glu | Cys | Ser | Asn | Arg | Arg | Leu | Gln | Glu | Val | Pro | Gln | Thr | Val | Gly | Lys | Tyr | Val | Thr | Glu | Leu | Asp | Leu | Ser | Asp |
Asn | Phe | Ile | Thr | His | Ile | Thr | Asn | Glu | Ser | Phe | Gln | Gly | Leu | Gln | Asn | Leu | Thr | Lys | Ile | Asn | Leu | Asn | His | Asn |
Pro | Asn | Val | Gln | His | Gln | Asn | Gly | Asn | Pro | Gly | Ile | Gln | Ser | Asn | Gly | Leu | Asn | Ile | Thr | Asp | Gly | Ala | Phe | Leu |
Asn | Leu | Lys | Asn | Leu | Arg | Glu | Leu | Leu | Leu | Glu | Asp | Asn | Gln | Leu | Pro | Gln | Ile | Pro | Ser | Gly | Leu | Pro | Glu | Ser |
Leu | Thr | Glu | Leu | Ser | Leu | Ile | Gln | Asn | Asn | Ile | Tyr | Asn | Ile | Thr | Lys | Glu | Gly | Ile | Ser | Arg | Leu | Ile | Asn | Leu |
Lys | Asn | Leu | Tyr | Leu | Ala | Trp | Asn | Cys | Tyr | Phe | Asn | Lys | Val | Cys | Glu | Lys | Thr | Asn | Ile | Glu | Asp | Gly | Val | Phe |
Glu | Thr | Leu | Thr | Asn | Leu | Glu | Leu | Leu | Ser | Leu | Ser | Phe | Asn | Ser | Leu | Ser | His | Val | Pro | Pro | Lys | Leu | Pro | Ser |
Ser | Leu | Arg | Lys | Leu | Phe | Leu | Ser | Asn | Thr | Gln | Ile | Lys | Tyr | Ile | Ser | Glu | Glu | Asp | Phe | Lys | Gly | Leu | Ile | Asn |
Leu | Thr | Leu | Leu | Asp | Leu | Ser | Gly | Asn | Cys | Pro | Arg | Cys | Phe | Asn | Ala | Pro | Phe | Pro | Cys | Val | Pro | Cys | Asp | Gly |
Gly | Ala | Ser | Ile | Asn | Ile | Asp | Arg | Phe | Ala | Phe | Gln | Asn | Leu | Thr | Gln | Leu | Arg | Tyr | Leu | Asn | Leu | Ser | Ser | Thr |
Ser | Leu | Arg | Lys | Ile | Asn | Ala | Ala | Trp | Phe | Lys | Asn | Met | Pro | His | Leu | Lys | Val | Leu | Asp | Leu | Glu | Phe | Asn | Tyr |
Leu | Val | Gly | Glu | Ile | Ala | Ser | Gly | Ala | Phe | Leu | Thr | Met | Leu | Pro | Arg | Leu | Glu | Ile | Leu | Asp | Leu | Ser | Phe | Asn |
Tyr | Ile | Lys | Gly | Ser | Tyr | Pro | Gln | His | Ile | Asn | Ile | Ser | Arg | Asn | Phe | Ser | Lys | Leu | Leu | Ser | Leu | Arg | Ala | Leu |
His | Leu | Arg | Gly | Tyr | Val | Phe | Gln | Glu | Leu | Arg | Glu | Asp | Asp | Phe | Gln | Pro | Leu | Met | Gln | Leu | Pro | Asn | Leu | Ser |
Thr | Ile | Asn | Leu | Gly | Ile | Asn | Phe | Ile | Lys | Gln | Ile | Asp | Phe | Lys | Leu | Phe | Gln | Asn | Phe | Ser | Asn | Leu | Glu | Ile |
Ile | Tyr | Leu | Ser | Glu | Asn | Arg | Ile | Ser | Pro | Leu | Val | Lys | Asp | Thr | Arg | Gln | Ser | Tyr | Ala | Asn | Ser | Ser | Ser | Phe |
Gln | Arg | His | Ile | Arg | Lys | Arg | Arg | Ser | Thr | Asp | Phe | Glu | Phe | Asp | Pro | His | Ser | Asn | Phe | Tyr | His | Phe | Thr | Arg |
Pro | Leu | Ile | Lys | Pro | Gln | Cys | Ala | Ala | Tyr | Gly | Lys | Ala | Leu | Asp | Leu | Ser | Leu | Asn | Ser | Ile | Phe | Phe | Ile | Gly |
Pro | Asn | Gln | Phe | Glu | Asn | Leu | Pro | Asp | Ile | Ala | Cys | Leu | Asn | Leu | Ser | Ala | Asn | Ser | Asn | Ala | Gln | Val | Leu | Ser |
Gly | Thr | Glu | Phe | Ser | Ala | Ile | Pro | His | Val | Lys | Tyr | Leu | Asp | Leu | Thr | Asn | Asn | Arg | Leu | Asp | Phe | Asp | Asn | Ala |
Ser | Ala | Leu | Thr | Glu | Leu | Ser | Asp | Leu | Glu | Val | Leu | Asp | Leu | Ser | Tyr | Asn | Ser | His | Tyr | Phe | Arg | Ile | Ala | Gly |
Val | Thr | His | His | Leu | Glu | Phe | Ile | Gln | Asn | Phe | Thr | Asn | Leu | Lys | Val | Leu | Asn | Leu | Ser | His | Asn | Asn | Ile | Tyr |
Thr | Leu | Thr | Asp | Lys | Tyr | Asn | Leu | Glu | Ser | Lys | Ser | Leu | Val | Glu | Leu | Val | Phe | Ser | Gly | Asn | Arg | Leu | Asp | Ile |
Leu | Trp | Asn | Asp | Asp | Asp | Asn | Arg | Tyr | Ile | Ser | Ile | Phe | Lys | Gly | Leu | Lys | Asn | Leu | Thr | Arg | Leu | Asp | Leu | Ser |
Leu | Asn | Arg | Leu | Lys | His | Ile | Pro | Asn | Glu | Ala | Phe | Leu | Asn | Leu | Pro | Ala | Ser | Leu | Thr | Glu | Leu | His | Ile | Asn |
Asp | Asn | Met | Leu | Lys | Phe | Phe | Asn | Trp | Thr | Leu | Leu | Gln | Gln | Phe | Pro | Arg | Leu | Glu | Leu | Leu | Asp | Leu | Arg | Gly |
Asn | Lys | Leu | Leu | Phe | Leu | Thr | Asp | Ser | Leu | Ser | Asp | Phe | Thr | Ser | Ser | Leu | Arg | Thr | Leu | Leu | Leu | Ser | His | Asn |
Arg | Ile | Ser | His | Leu | Pro | Ser | Gly | Phe | Leu | Ser | Glu | Val | Ser | Ser | Leu | Lys | His | Leu | Asp | Leu | Ser | Ser | Asn | Leu |
Leu | Lys | Thr | Ile | Asn | Lys | Ser | Ala | Leu | Glu | Thr | Lys | Thr | Thr | Thr | Lys | Leu | Ser | Met | Leu | Glu | Leu | His | Gly | Asn |
Pro | Phe | Glu | Cys | Thr | Cys | Asp | Ile | Gly | Asp | Phe | Arg | Arg | Trp | Met | Asp | Glu | His | Leu | Asn | Val | Lys | Ile | Pro | Arg |
Leu | Val | Asp | Val | Ile | Cys | Ala | Ser | Pro | Gly | Asp | Gln | Arg | Gly | Lys | Ser | Ile | Val | Ser | Leu | Glu | Leu | Thr | Thr | Cys |
Val | Ser | Asp | Val | Thr | Glu | Phe | Leu | Val | Pro | Arg |
[左]5AWCのChain A・B [右]5AZ5のChain A・B
5AWA・5AWC・5AZ5のPDBsumデータ(いずれもChain A) ※前2者については J. Med. Chem. 参照
5WYX(CU-CPT8m結合)・5WYZ(CU-CPT9b結合)・5Z14(CU-CPT9a結合)・5Z15(CU-CPT9c結合)のPDBsumデータ(いずれもChain A)
左から: 6TY5と同PDBsumデータ,6V9Uと同PDBsumデータ
[左]6ZJZ(阻害剤M5049結合)と同PDBsumデータ [右]6WMLのChain A(TLR8アゴニストのGS-9688〈セルガントリモド,selgantolimod〉結合)と同PDBsumデータ
7crf(CU-CPD107結合)と同PDBsumデータ
→ PDBsumサイトで入手したAlphaFold構造
7r53のChain A(アンタゴニストcompound 15が結合)と同PDBsumデータ(compound 2結合の7r52,compound 4結合の7r54との比較)
7rc9のChain A(アンタゴニストcompound 21〈BMS-905〉が結合)と同PDBsumデータ
7ytxのChain A(アンタゴニストE6742が結合)と同PDBsumデータ
8pfiのChain A(アンタゴニストMHV370が結合)と同PDBsumデータ
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3WPC(CpG配列を有するアンタゴニストDNAが結合) ※PDB 3WPB~3WPIが同一研究で構造解明 4QDH 5Y3M(CpGおよび5'XCXモチーフDNAとの複合体) ※PDB 5Y3J~5Y3Lが同一研究で構造解明 | 5ZLN(CpG DNAおよびTCGCCA DNAとの複合体) ※ほぼ同じ研究グループによる バックボーン 二次構造 DNA/RNA(ATGCU,backbone) 全選択 タンパク質選択 DNA/RNA選択 同backbone選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
[左]5Y3M(TLR9とCpGおよび5'XCXモチーフDNAとの複合体構造;DNA塩基をATGC着色)
[右]5ZLN(TLR9とCpGおよびTCGCCAモチーフDNAとの複合体構造)
3WPC(DNAをATGC着色し,青色は糖鎖 NAG;右はDNA近傍の拡大図)
※参考:自然免疫応答を引き起こすタンパク質が微生物の侵入を感知する仕組みを解明 ~抗ウイルス薬やワクチンなどの開発に期待~(JST,2015/02/10)
Arg | Ser | Pro | Trp | Gln | Gly | Thr | Leu | Pro | Pro | Phe | Leu | Pro | Cys | Glu | Leu | Gln | Pro | His | Gly | Leu | Val | Asn | Cys | Asn |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Trp | Leu | Phe | Leu | Lys | Ser | Val | Pro | His | Phe | Ser | Ala | Ala | Ala | Pro | Arg | Asp | Asn | Val | Thr | Ser | Leu | Ser | Leu | Leu |
Ser | Asn | Arg | Ile | His | His | Leu | His | Asp | Ser | Asp | Phe | Ala | Gln | Leu | Ser | Asn | Leu | Gln | Lys | Leu | Asn | Leu | Lys | Trp |
Asn | Cys | Pro | Pro | Ala | Gly | Leu | Ser | Pro | Met | His | Phe | Pro | Cys | His | Met | Thr | Ile | Glu | Pro | Asn | Thr | Phe | Leu | Ala |
Val | Pro | Thr | Leu | Glu | Glu | Leu | Asn | Leu | Ser | Tyr | Asn | Gly | Ile | Thr | Thr | Val | Pro | Ala | Leu | Pro | Ser | Ser | Leu | Val |
Ser | Leu | Ile | Leu | Ser | Arg | Thr | Asn | Ile | Leu | Gln | Leu | Asp | Pro | Thr | Ser | Leu | Thr | Gly | Leu | His | Ala | Leu | Arg | Phe |
Leu | Tyr | Met | Asp | Gly | Asn | Cys | Tyr | Tyr | Lys | Asn | Pro | Cys | Gly | Arg | Ala | Leu | Glu | Val | Ala | Pro | Gly | Ala | Leu | Leu |
Gly | Leu | Gly | Asn | Leu | Thr | His | Leu | Ser | Leu | Lys | Tyr | Asn | Asn | Leu | Thr | Thr | Val | Pro | Arg | Ser | Leu | Pro | Pro | Ser |
Leu | Glu | Tyr | Leu | Leu | Leu | Ser | Tyr | Asn | His | Ile | Val | Thr | Leu | Ala | Pro | Glu | Asp | Leu | Ala | Asn | Leu | Thr | Ala | Leu |
Arg | Val | Leu | Asp | Val | Gly | Gly | Asn | Cys | Arg | Arg | Cys | Asp | His | Ala | Arg | Asn | Pro | Cys | Val | Glu | Cys | Pro | His | Lys |
Phe | Pro | Gln | Leu | His | Ser | Asp | Thr | Phe | Ser | His | Leu | Ser | Arg | Leu | Glu | Gly | Leu | Val | Leu | Lys | Asp | Ser | Ser | Leu |
Tyr | Gln | Leu | Asn | Pro | Arg | Trp | Phe | Arg | Gly | Leu | Gly | Asn | Leu | Thr | Val | Leu | Asp | Leu | Ser | Glu | Asn | Phe | Leu | Tyr |
Asp | Cys | Ile | Thr | Lys | Thr | Lys | Ala | Phe | Gln | Gly | Leu | Ala | Gln | Leu | Arg | Arg | Leu | Asn | Leu | Ser | Phe | Asn | Tyr | His |
Lys | Lys | Val | Ser | Phe | Ala | His | Leu | Thr | Leu | Ala | Pro | Ser | Phe | Gly | Ser | Leu | Leu | Ser | Leu | Gln | Glu | Leu | Asp | Met |
His | Gly | Ile | Phe | Phe | Arg | Ser | Leu | Ser | Gln | Lys | Thr | Leu | Gln | Pro | Leu | Ala | Arg | Leu | Pro | Met | Leu | Gln | Arg | Leu |
Tyr | Leu | Gln | Met | Asn | Phe | Ile | Asn | Gln | Ala | Gln | Leu | Gly | Ile | Phe | Lys | Asp | Phe | Pro | Gly | Leu | Arg | Tyr | Ile | Asp |
Leu | Ser | Asp | Asn | Arg | Ile | Ser | Gly | Ala | Val | Glu | Pro | Val | Ala | Thr | Thr | Gly | Glu | Val | Asp | Gly | Gly | Lys | Lys | Val |
Trp | Leu | Thr | Ser | Arg | Asp | Leu | Thr | Pro | Gly | Pro | Leu | Asp | Thr | Pro | Ser | Ser | Glu | Asp | Phe | Met | Pro | Ser | Cys | Lys |
Asn | Leu | Ser | Phe | Thr | Leu | Asp | Leu | Ser | Arg | Asn | Asn | Leu | Val | Thr | Val | Gln | Pro | Glu | Met | Phe | Ala | Gln | Leu | Ser |
Arg | Leu | Gln | Cys | Leu | Arg | Leu | Ser | His | Asn | Ser | Ile | Ser | Gln | Ala | Val | Asn | Gly | Ser | Gln | Phe | Val | Pro | Leu | Thr |
Ser | Leu | Gln | Val | Leu | Asp | Leu | Ser | His | Asn | Lys | Leu | Asp | Leu | Tyr | His | Gly | Arg | Ser | Phe | Thr | Glu | Leu | Pro | Arg |
Leu | Glu | Ala | Leu | Asp | Leu | Ser | Tyr | Asn | Ser | Gln | Pro | Phe | Ser | Met | Arg | Gly | Val | Gly | His | Asn | Leu | Ser | Phe | Val |
Ala | Gln | Leu | Pro | Thr | Leu | Arg | Tyr | Leu | Ser | Leu | Ala | His | Asn | Gly | Ile | His | Ser | Arg | Val | Ser | Gln | Gln | Leu | Cys |
Ser | Thr | Ser | Leu | Trp | Ala | Leu | Asp | Phe | Ser | Gly | Asn | Ser | Leu | Ser | Gln | Met | Trp | Ala | Glu | Gly | Asp | Leu | Tyr | Leu |
Arg | Phe | Phe | Gln | Gly | Leu | Arg | Ser | Leu | Ile | Arg | Leu | Asp | Leu | Ser | Gln | Asn | Arg | Leu | His | Thr | Leu | Leu | Pro | Cys |
Thr | Leu | Gly | Asn | Leu | Pro | Lys | Ser | Leu | Gln | Leu | Leu | Arg | Leu | Arg | Asn | Asn | Tyr | Leu | Ala | Phe | Phe | Asn | Trp | Ser |
Ser | Leu | Thr | Leu | Leu | Pro | Asn | Leu | Glu | Thr | Leu | Asp | Leu | Ala | Gly | Asn | Gln | Leu | Lys | Ala | Leu | Ser | Asn | Gly | Ser |
Leu | Pro | Ser | Gly | Thr | Gln | Leu | Gln | Arg | Leu | Asp | Val | Ser | Arg | Asn | Ser | Ile | Ile | Phe | Val | Val | Pro | Gly | Phe | Phe |
Ala | Leu | Ala | Thr | Arg | Leu | Arg | Glu | Leu | Asn | Leu | Ser | Ala | Asn | Ala | Leu | Arg | Thr | Val | Glu | Pro | Ser | Trp | Phe | Gly |
Phe | Leu | Ala | Gly | Ser | Leu | Glu | Val | Leu | Asp | Val | Ser | Ala | Asn | Pro | Leu | His | Cys | Ala | Cys | Gly | Ala | Ala | Phe | Val |
Asp | Phe | Leu | Leu | Gln | Val | Gln | Ala | Ala | Val | Pro | Gly | Leu | Pro | Ser | Arg | Val | Lys | Cys | Gly | Ser | Pro | Gly | Gln | Leu |
Gln | Gly | Arg | Ser | Ile | Phe | Ala | Gln | Asp | Leu | Arg | Leu | Cys | Leu | Asp | Glu | Ser | Leu | Ser | Trp | Asp | Glu | Phe | Leu | Val |
Pro | Arg |
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バックボーン 二次構造 全 HB選択($印のみ)選択 タンパク質選択 リガンド選択 HB選択($印のみ) Leu選択 BCAA球表示(Leu Ile Val) 空間充填 球棒 球60% スティック 針金 アミノ色 Chain色 CPK色 ∥ Jmol色 Rasmol色 酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックス・βストランド)# ヒトの必須・非必須区別 糖鎖別着色: Gal,α-Glc,β-Glc,Man,Fuc,Xyl,Sia,GalNAc,GlcNAc,GlcA 水素結合(太) OFF 背景・黒 灰 白 紺 |
※参考:「新しい自然免疫学 ―免疫システムの真の主役」(技術評論社),p.107~