Toll様受容体はロイシンリッチリピートをもつ

Glu	Pro	Cys	Val	Glu	Val	Val	Pro	Asn	Ile	Thr	Tyr	Gln	Cys	Met	Glu	Leu	Asn	Phe	Tyr	Lys	Ile	Pro	Asp	Asn
Leu	Pro	Phe	Ser	Thr	Lys	Asn	Leu	Asp	Leu	Ser	Phe	Asn	Pro	Leu	Arg	His	Leu	Gly	Ser	Tyr	Ser	Phe	Phe	Ser
Phe	Pro	Glu	Leu	Gln	Val	Leu	Asp	Leu	Ser	Arg	Cys	Glu	Ile	Gln	Thr	Ile	Glu	Asp	Gly	Ala	Tyr	Gln	Ser	Leu
Ser	His	Leu	Ser	Thr	Leu	Ile	Leu	Thr	Gly	Asn	Pro	Ile	Gln	Ser	Leu	Ala	Leu	Gly	Ala	Phe	Ser	Gly	Leu	Ser
Ser	Leu	Gln	Lys	Leu	Val	Ala	Val	Glu	Thr	Asn	Leu	Ala	Ser	Leu	Glu	Asn	Phe	Pro	Ile	Gly	His	Leu	Lys	Thr
Leu	Lys	Glu	Leu	Asn	Val	Ala	His	Asn	Leu	Ile	Gln	Ser	Phe	Lys	Leu	Pro	Glu	Tyr	Phe	Ser	Asn	Leu	Thr	Asn
Leu	Glu	His	Leu	Asp	Leu	Ser	Ser	Asn	Lys	Ile	Gln	Ser	Ile	Tyr	Cys	Thr	Asp	Leu	Arg	Val	Leu	His	Gln	Met
Pro	Leu	Leu	Asn	Leu	Ser	Leu	Asp	Leu	Ser	Leu	Asn	Pro	Met	Asn	Phe	Ile	Gln	Pro	Gly	Ala	Phe	Lys	Glu	Ile
Arg	Leu	His	Lys	Leu	Thr	Leu	Arg	Asn	Asn	Phe	Asp	Ser	Leu	Asn	Val	Met	Lys	Thr	Cys	Ile	Gln	Gly	Leu	Ala
Gly	Leu	Glu	Val	His	Arg	Leu	Val	Leu	Gly	Glu	Phe	Arg	Asn	Glu	Gly	Asn	Leu	Glu	Lys	Phe	Asp	Lys	Ser	Ala
Leu	Glu	Gly	Leu	Cys	Asn	Leu	Thr	Ile	Glu	Glu	Phe	Arg	Leu	Ala	Tyr	Leu	Asp	Tyr	Tyr	Leu	Asp	Asp	Ile	Ile
Asp	Leu	Phe	Asn	Cys	Leu	Thr	Asn	Val	Ser	Ser	Phe	Ser	Leu	Val	Ser	Val	Thr	Ile	Glu	Arg	Val	Lys	Asp	Phe
Ser	Tyr	Asn	Phe	Gly	Trp	Gln	His	Leu	Glu	Leu	Val	Asn	Cys	Lys	Phe	Gly	Gln	Phe	Pro	Thr	Leu	Lys	Leu	Lys
Ser	Leu	Lys	Arg	Leu	Thr	Phe	Thr	Ser	Asn	Lys	Gly	Gly	Asn	Ala	Phe	Ser	Glu	Val	Asp	Leu	Pro	Ser	Leu	Glu
Phe	Leu	Asp	Leu	Ser	Arg	Asn	Gly	Leu	Ser	Phe	Lys	Gly	Cys	Cys	Ser	Gln	Ser	Asp	Phe	Gly	Thr	Thr	Ser	Leu
Lys	Tyr	Leu	Asp	Leu	Ser	Phe	Asn	Gly	Val	Ile	Thr	Met	Ser	Ser	Asn	Phe	Leu	Gly	Leu	Glu	Gln	Leu	Glu	His
Leu	Asp	Phe	Gln	His	Ser	Asn	Leu	Lys	Gln	Met	Ser	Glu	Phe	Ser	Val	Phe	Leu	Ser	Leu	Arg	Asn	Leu	Ile	Tyr
Leu	Asp	Ile	Ser	His	Thr	His	Thr	Arg	Val	Ala	Phe	Asn	Gly	Ile	Phe	Asn	Gly	Leu	Ser	Ser	Leu	Glu	Val	Leu
Lys	Met	Ala	Gly	Asn	Ser	Phe	Gln	Glu	Asn	Phe	Leu	Pro	Asp	Ile	Phe	Thr	Glu	Leu	Arg	Asn	Leu	Thr	Phe	Leu
Asp	Leu	Ser	Gln	Cys	Gln	Leu	Glu	Gln	Leu	Ser	Pro	Thr	Ala	Phe	Asn	Ser	Leu	Ser	Ser	Leu	Gln	Val	Leu	Asn
Met	Ser	His	Asn	Asn	Phe	Phe	Ser	Leu	Asp	Thr	Phe	Pro	Tyr	Lys	Cys	Leu	Asn	Ser	Leu	Gln	Val	Leu	Asp	Tyr
Ser	Leu	Asn	His	Ile	Met	Thr	Ser	Lys	Lys	Gln	Glu	Leu	Gln	His	Phe	Pro	Ser	Ser	Leu	Ala	Phe	Leu	Asn	Leu
Thr	Gln	Asn	Asp	Phe	Ala	Cys	Thr	Cys	Glu	His	Gln	Ser	Phe	Leu	Gln	Trp	Ile	Lys	Asp	Gln	Arg	Gln	Leu	Leu
Val	Glu	Val	Glu	Arg	Met	Glu	Cys	Ala	Thr	Pro	Ser	Asp	Lys	Gln	Gly	Met	Pro	Val	Leu	Ser	Leu	Asn	Ile	Thr
Cys	Gln	Met	Asn	Lys

17.4％

●ロイシンジッパー　→

科学未来館展示のタンパク質

ロイシンジッパー1A02のF・J鎖＋DNA

バックボーン　二次構造
DNA/RNA（ATGCU，backbone）
全選択　タンパク質選択
リガンド選択　Leu選択　BCAA球表示（Leu Ile Val）
DNA/RNA選択　同backbone選択
空間充填　球棒　球60％　スティック　針金
アミノ色　Chain色　CPK色　∥　Jmol色　Rasmol色

酸性・中性・塩基性区別　極性・非極性区別
疎水性インデックス順　I/O値順（特性基 R）　等電点順
コンホメーション選択性（αヘリックス・βストランド）#
水素結合（太）　OFF
　
　
背景・黒　灰　白　紺

1A02

Met	Lys	Arg	Arg	Ile	Arg	Arg	Glu	Arg	Asn	Lys	Met	Ala	Ala	Ala	Lys	Ser	Arg	Asn	Arg	Arg	Arg	Glu	Leu	Thr
Asp	Thr	Leu	Gln	Ala	Glu	Thr	Asp	Gln	Leu	Glu	Asp	Glu	Lys	Ser	Ala	Leu	Gln	Thr	Glu	Ile	Ala	Asn	Leu	Leu
Lys	Glu	Lys	Glu	Lys	Leu

12.5％

●ヘモグロビン　→

ヘモグロビンとヘモグロビンS

オキシヘモグロビン1HHOのA鎖

バックボーン　二次構造
全選択　タンパク質選択
リガンド選択　Leu選択　BCAA球表示（Leu Ile Val）
空間充填　球棒　球60％　スティック　針金
アミノ色　Chain色　CPK色　∥　Jmol色　Rasmol色

酸性・中性・塩基性区別　極性・非極性区別
疎水性インデックス順　I/O値順（特性基 R）　等電点順
コンホメーション選択性（αヘリックス・βストランド）#
水素結合（太）　OFF
　
　
背景・黒　灰　白　紺

1HHO

Val	Leu	Ser	Pro	Ala	Asp	Lys	Thr	Asn	Val	Lys	Ala	Ala	Trp	Gly	Lys	Val	Gly	Ala	His	Ala	Gly	Glu	Tyr	Gly
Ala	Glu	Ala	Leu	Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Thr	Thr	Lys	Thr	Tyr	Phe	Pro	His	Phe	Asp	Leu	Ser	His
Gly	Ser	Ala	Gln	Val	Lys	Gly	His	Gly	Lys	Lys	Val	Ala	Asp	Ala	Leu	Thr	Asn	Ala	Val	Ala	His	Val	Asp	Asp
Met	Pro	Asn	Ala	Leu	Ser	Ala	Leu	Ser	Asp	Leu	His	Ala	His	Lys	Leu	Arg	Val	Asp	Pro	Val	Asn	Phe	Lys	Leu
Leu	Ser	His	Cys	Leu	Leu	Val	Thr	Leu	Ala	Ala	His	Leu	Pro	Ala	Glu	Phe	Thr	Pro	Ala	Val	His	Ala	Ser	Leu
Asp	Lys	Phe	Leu	Ala	Ser	Val	Ser	Thr	Val	Leu	Thr	Ser	Lys	Tyr	Arg

12.8％

●P450　→

P450データ集メニュー

シトクロムP4501DZ8のA鎖

バックボーン　二次構造
全選択　タンパク質選択
リガンド選択　Leu選択　BCAA球表示（Leu Ile Val）

空間充填　球棒　球60％　スティック　針金
アミノ色　Chain色　CPK色　∥　Jmol色　Rasmol色

酸性・中性・塩基性区別　極性・非極性区別
疎水性インデックス順　I/O値順（特性基 R）　等電点順
コンホメーション選択性（αヘリックス・βストランド）#
水素結合（太）　OFF
　
　
背景・黒　灰　白　紺

1DZ8

Thr	Thr	Glu	Thr	Ile	Gln	Ser	Asn	Ala	Asn	Leu	Ala	Pro	Leu	Pro	Pro	His	Val	Pro	Glu	His	Leu	Val	Phe	Asp
Phe	Asp	Met	Tyr	Asn	Pro	Ser	Asn	Leu	Ser	Ala	Gly	Val	Gln	Glu	Ala	Trp	Ala	Val	Leu	Gln	Glu	Ser	Asn	Val
Pro	Asp	Leu	Val	Trp	Thr	Arg	Cys	Asn	Gly	Gly	His	Trp	Ile	Ala	Thr	Arg	Gly	Gln	Leu	Ile	Arg	Glu	Ala	Tyr
Glu	Asp	Tyr	Arg	His	Phe	Ser	Ser	Glu	Cys	Pro	Phe	Ile	Pro	Arg	Glu	Ala	Gly	Glu	Ala	Tyr	Asp	Phe	Ile	Pro
Thr	Ser	Met	Asp	Pro	Pro	Glu	Gln	Arg	Gln	Phe	Arg	Ala	Leu	Ala	Asn	Gln	Val	Val	Gly	Met	Pro	Val	Val	Asp
Lys	Leu	Glu	Asn	Arg	Ile	Gln	Glu	Leu	Ala	Cys	Ser	Leu	Ile	Glu	Ser	Leu	Arg	Pro	Gln	Gly	Gln	Cys	Asn	Phe
Thr	Glu	Asp	Tyr	Ala	Glu	Pro	Phe	Pro	Ile	Arg	Ile	Phe	Met	Leu	Leu	Ala	Gly	Leu	Pro	Glu	Glu	Asp	Ile	Pro
His	Leu	Lys	Tyr	Leu	Thr	Asp	Gln	Met	Thr	Arg	Pro	Asp	Gly	Ser	Met	Thr	Phe	Ala	Glu	Ala	Lys	Glu	Ala	Leu
Tyr	Asp	Tyr	Leu	Ile	Pro	Ile	Ile	Glu	Gln	Arg	Arg	Gln	Lys	Pro	Gly	Thr	Asp	Ala	Ile	Ser	Ile	Val	Ala	Asn
Gly	Gln	Val	Asn	Gly	Arg	Pro	Ile	Thr	Ser	Asp	Glu	Ala	Lys	Arg	Met	Cys	Gly	Leu	Leu	Leu	Val	Gly	Gly	Leu
Asp	Thr	Val	Val	Asn	Phe	Leu	Ser	Phe	Ser	Met	Glu	Phe	Leu	Ala	Lys	Ser	Pro	Glu	His	Arg	Gln	Glu	Leu	Ile
Gln	Arg	Pro	Glu	Arg	Ile	Pro	Ala	Ala	Cys	Glu	Glu	Leu	Leu	Arg	Arg	Phe	Ser	Leu	Val	Ala	Asp	Gly	Arg	Ile
Leu	Thr	Ser	Asp	Tyr	Glu	Phe	His	Gly	Val	Gln	Leu	Lys	Lys	Gly	Asp	Gln	Ile	Leu	Leu	Pro	Gln	Met	Leu	Ser
Gly	Leu	Asp	Glu	Arg	Glu	Asn	Ala	Cys	Pro	Met	His	Val	Asp	Phe	Ser	Arg	Gln	Lys	Val	Ser	His	Thr	Thr	Phe
Gly	His	Gly	Ser	His	Leu	Cys	Leu	Gly	Gln	His	Leu	Ala	Arg	Arg	Glu	Ile	Ile	Val	Thr	Leu	Lys	Glu	Trp	Leu
Thr	Arg	Ile	Pro	Asp	Phe	Ser	Ile	Ala	Pro	Gly	Ala	Gln	Ile	Gln	His	Lys	Ser	Gly	Ile	Val	Ser	Gly	Val	Gln
Ala	Leu	Pro	Leu	Val	Trp	Asp	Pro	Ala	Thr	Thr	Lys	Ala	Val

10.1％

●GFP　→

緑色蛍光を発するタンパク質（GFP）

緑色蛍光タンパク質（GFP）1HCJのA鎖

バックボーン　二次構造
全選択　タンパク質選択
リガンド選択　Leu選択　BCAA球表示（Leu Ile Val）

空間充填　球棒　球60％　スティック　針金
アミノ色　Chain色　CPK色　∥　Jmol色　Rasmol色

酸性・中性・塩基性区別　極性・非極性区別
疎水性インデックス順　I/O値順（特性基 R）　等電点順
コンホメーション選択性（αヘリックス・βストランド）#
水素結合（太）　OFF
　
　
背景・黒　灰　白　紺

1HCJ

Met	Ser	Lys	Gly	Glu	Glu	Leu	Phe	Thr	Gly	Val	Val	Pro	Ile	Leu	Val	Glu	Leu	Asp	Gly	Asp	Val	Asn	Gly	His
Lys	Phe	Ser	Val	Ser	Gly	Glu	Gly	Glu	Gly	Asp	Ala	Thr	Tyr	Gly	Lys	Leu	Thr	Leu	Lys	Phe	Ile	Cys	Thr	Thr
Gly	Lys	Leu	Pro	Val	Pro	Trp	Pro	Thr	Leu	Val	Thr	Thr	Phe	Ser	Tyr	Gly	Val	Gln	Cys	Phe	Ser	Arg	Tyr	Pro
Asp	His	Met	Lys	Arg	His	Asp	Phe	Phe	Lys	Ser	Ala	Met	Pro	Glu	Gly	Tyr	Val	Gln	Glu	Arg	Thr	Ile	Phe	Phe
Lys	Asp	Asp	Gly	Asn	Tyr	Lys	Thr	Arg	Ala	Glu	Val	Lys	Phe	Glu	Gly	Asp	Thr	Leu	Val	Asn	Arg	Ile	Glu	Leu
Lys	Gly	Ile	Asp	Phe	Lys	Glu	Asp	Gly	Asn	Ile	Leu	Gly	His	Lys	Leu	Glu	Tyr	Asn	Tyr	Asn	Ser	His	Asn	Val
Tyr	Ile	Met	Ala	Asp	Lys	Gln	Lys	Asn	Gly	Ile	Lys	Val	Asn	Phe	Lys	Ile	Arg	His	Asn	Ile	Glu	Asp	Gly	Ser
Val	Gln	Leu	Ala	Asp	His	Tyr	Gln	Gln	Asn	Thr	Pro	Ile	Gly	Asp	Gly	Pro	Val	Leu	Leu	Pro	Asp	Asn	His	Tyr
Leu	Ser	Thr	Gln	Ser	Ala	Leu	Ser	Lys	Asp	Pro	Asn	Glu	Lys	Arg	Asp	His	Met	Val	Leu	Leu	Glu	Phe	Val	Thr
Ala	Ala	Gly	Ile	Thr	His	Gly	Met	Asp	Glu	Leu	Tyr	Lys

7.98％

●イオンチャネル　→

イオンチャネルタンパク質の例

イオンチャネル1BL8（カリウムチャネル）

バックボーン　二次構造
全選択　タンパク質選択
リガンド選択　Leu選択　BCAA球表示（Leu Ile Val）

空間充填　球棒　球60％　スティック　針金
アミノ色　Chain色　CPK色　∥　Jmol色　Rasmol色

酸性・中性・塩基性区別　極性・非極性区別
疎水性インデックス順　I/O値順（特性基 R）　等電点順
コンホメーション選択性（αヘリックス・βストランド）#
水素結合（太）　OFF
　
　
背景・黒　灰　白　紺

1BL8

Ala	Leu	His	Trp	Arg	Ala	Ala	Gly	Ala	Ala	Thr	Val	Leu	Leu	Val	Ile	Val	Leu	Leu	Ala	Gly	Ser	Tyr	Leu	Ala
Val	Leu	Ala	Glu	Arg	Gly	Ala	Pro	Gly	Ala	Gln	Leu	Ile	Thr	Tyr	Pro	Arg	Ala	Leu	Trp	Trp	Ser	Val	Glu	Thr
Ala	Thr	Thr	Val	Gly	Tyr	Gly	Asp	Leu	Tyr	Pro	Val	Thr	Leu	Trp	Gly	Arg	Cys	Val	Ala	Val	Val	Val	Met	Val
Ala	Gly	Ile	Thr	Ser	Phe	Gly	Leu	Val	Thr	Ala	Ala	Leu	Ala	Thr	Trp	Phe	Val	Gly	Arg	Glu	Gln

13.4％

「生活環境化学の部屋」ホームページ｜ Jmol版「分子の学習帳」｜ Chime版「分子の学習帳」

Glu	Pro	Cys	Val	Glu	Val	Val	Pro	Asn	Ile	Thr	Tyr	Gln	Cys	Met	Glu	Leu	Asn	Phe	Tyr	Lys	Ile	Pro	Asp	Asn
Leu	Pro	Phe	Ser	Thr	Lys	Asn	Leu	Asp	Leu	Ser	Phe	Asn	Pro	Leu	Arg	His	Leu	Gly	Ser	Tyr	Ser	Phe	Phe	Ser
Phe	Pro	Glu	Leu	Gln	Val	Leu	Asp	Leu	Ser	Arg	Cys	Glu	Ile	Gln	Thr	Ile	Glu	Asp	Gly	Ala	Tyr	Gln	Ser	Leu
Ser	His	Leu	Ser	Thr	Leu	Ile	Leu	Thr	Gly	Asn	Pro	Ile	Gln	Ser	Leu	Ala	Leu	Gly	Ala	Phe	Ser	Gly	Leu	Ser
Ser	Leu	Gln	Lys	Leu	Val	Ala	Val	Glu	Thr	Asn	Leu	Ala	Ser	Leu	Glu	Asn	Phe	Pro	Ile	Gly	His	Leu	Lys	Thr
Leu	Lys	Glu	Leu	Asn	Val	Ala	His	Asn	Leu	Ile	Gln	Ser	Phe	Lys	Leu	Pro	Glu	Tyr	Phe	Ser	Asn	Leu	Thr	Asn
Leu	Glu	His	Leu	Asp	Leu	Ser	Ser	Asn	Lys	Ile	Gln	Ser	Ile	Tyr	Cys	Thr	Asp	Leu	Arg	Val	Leu	His	Gln	Met
Pro	Leu	Leu	Asn	Leu	Ser	Leu	Asp	Leu	Ser	Leu	Asn	Pro	Met	Asn	Phe	Ile	Gln	Pro	Gly	Ala	Phe	Lys	Glu	Ile
Arg	Leu	His	Lys	Leu	Thr	Leu	Arg	Asn	Asn	Phe	Asp	Ser	Leu	Asn	Val	Met	Lys	Thr	Cys	Ile	Gln	Gly	Leu	Ala
Gly	Leu	Glu	Val	His	Arg	Leu	Val	Leu	Gly	Glu	Phe	Arg	Asn	Glu	Gly	Asn	Leu	Glu	Lys	Phe	Asp	Lys	Ser	Ala
Leu	Glu	Gly	Leu	Cys	Asn	Leu	Thr	Ile	Glu	Glu	Phe	Arg	Leu	Ala	Tyr	Leu	Asp	Tyr	Tyr	Leu	Asp	Asp	Ile	Ile
Asp	Leu	Phe	Asn	Cys	Leu	Thr	Asn	Val	Ser	Ser	Phe	Ser	Leu	Val	Ser	Val	Thr	Ile	Glu	Arg	Val	Lys	Asp	Phe
Ser	Tyr	Asn	Phe	Gly	Trp	Gln	His	Leu	Glu	Leu	Val	Asn	Cys	Lys	Phe	Gly	Gln	Phe	Pro	Thr	Leu	Lys	Leu	Lys
Ser	Leu	Lys	Arg	Leu	Thr	Phe	Thr	Ser	Asn	Lys	Gly	Gly	Asn	Ala	Phe	Ser	Glu	Val	Asp	Leu	Pro	Ser	Leu	Glu
Phe	Leu	Asp	Leu	Ser	Arg	Asn	Gly	Leu	Ser	Phe	Lys	Gly	Cys	Cys	Ser	Gln	Ser	Asp	Phe	Gly	Thr	Thr	Ser	Leu
Lys	Tyr	Leu	Asp	Leu	Ser	Phe	Asn	Gly	Val	Ile	Thr	Met	Ser	Ser	Asn	Phe	Leu	Gly	Leu	Glu	Gln	Leu	Glu	His
Leu	Asp	Phe	Gln	His	Ser	Asn	Leu	Lys	Gln	Met	Ser	Glu	Phe	Ser	Val	Phe	Leu	Ser	Leu	Arg	Asn	Leu	Ile	Tyr
Leu	Asp	Ile	Ser	His	Thr	His	Thr	Arg	Val	Ala	Phe	Asn	Gly	Ile	Phe	Asn	Gly	Leu	Ser	Ser	Leu	Glu	Val	Leu
Lys	Met	Ala	Gly	Asn	Ser	Phe	Gln	Glu	Asn	Phe	Leu	Pro	Asp	Ile	Phe	Thr	Glu	Leu	Arg	Asn	Leu	Thr	Phe	Leu
Asp	Leu	Ser	Gln	Cys	Gln	Leu	Glu	Gln	Leu	Ser	Pro	Thr	Ala	Phe	Asn	Ser	Leu	Ser	Ser	Leu	Gln	Val	Leu	Asn
Met	Ser	His	Asn	Asn	Phe	Phe	Ser	Leu	Asp	Thr	Phe	Pro	Tyr	Lys	Cys	Leu	Asn	Ser	Leu	Gln	Val	Leu	Asp	Tyr
Ser	Leu	Asn	His	Ile	Met	Thr	Ser	Lys	Lys	Gln	Glu	Leu	Gln	His	Phe	Pro	Ser	Ser	Leu	Ala	Phe	Leu	Asn	Leu
Thr	Gln	Asn	Asp	Phe	Ala	Cys	Thr	Cys	Glu	His	Gln	Ser	Phe	Leu	Gln	Trp	Ile	Lys	Asp	Gln	Arg	Gln	Leu	Leu
Val	Glu	Val	Glu	Arg	Met	Glu	Cys	Ala	Thr	Pro	Ser	Asp	Lys	Gln	Gly	Met	Pro	Val	Leu	Ser	Leu	Asn	Ile	Thr
Cys	Gln	Met	Asn	Lys

Met	Lys	Arg	Arg	Ile	Arg	Arg	Glu	Arg	Asn	Lys	Met	Ala	Ala	Ala	Lys	Ser	Arg	Asn	Arg	Arg	Arg	Glu	Leu	Thr
Asp	Thr	Leu	Gln	Ala	Glu	Thr	Asp	Gln	Leu	Glu	Asp	Glu	Lys	Ser	Ala	Leu	Gln	Thr	Glu	Ile	Ala	Asn	Leu	Leu
Lys	Glu	Lys	Glu	Lys	Leu

Val	Leu	Ser	Pro	Ala	Asp	Lys	Thr	Asn	Val	Lys	Ala	Ala	Trp	Gly	Lys	Val	Gly	Ala	His	Ala	Gly	Glu	Tyr	Gly
Ala	Glu	Ala	Leu	Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Thr	Thr	Lys	Thr	Tyr	Phe	Pro	His	Phe	Asp	Leu	Ser	His
Gly	Ser	Ala	Gln	Val	Lys	Gly	His	Gly	Lys	Lys	Val	Ala	Asp	Ala	Leu	Thr	Asn	Ala	Val	Ala	His	Val	Asp	Asp
Met	Pro	Asn	Ala	Leu	Ser	Ala	Leu	Ser	Asp	Leu	His	Ala	His	Lys	Leu	Arg	Val	Asp	Pro	Val	Asn	Phe	Lys	Leu
Leu	Ser	His	Cys	Leu	Leu	Val	Thr	Leu	Ala	Ala	His	Leu	Pro	Ala	Glu	Phe	Thr	Pro	Ala	Val	His	Ala	Ser	Leu
Asp	Lys	Phe	Leu	Ala	Ser	Val	Ser	Thr	Val	Leu	Thr	Ser	Lys	Tyr	Arg

Thr	Thr	Glu	Thr	Ile	Gln	Ser	Asn	Ala	Asn	Leu	Ala	Pro	Leu	Pro	Pro	His	Val	Pro	Glu	His	Leu	Val	Phe	Asp
Phe	Asp	Met	Tyr	Asn	Pro	Ser	Asn	Leu	Ser	Ala	Gly	Val	Gln	Glu	Ala	Trp	Ala	Val	Leu	Gln	Glu	Ser	Asn	Val
Pro	Asp	Leu	Val	Trp	Thr	Arg	Cys	Asn	Gly	Gly	His	Trp	Ile	Ala	Thr	Arg	Gly	Gln	Leu	Ile	Arg	Glu	Ala	Tyr
Glu	Asp	Tyr	Arg	His	Phe	Ser	Ser	Glu	Cys	Pro	Phe	Ile	Pro	Arg	Glu	Ala	Gly	Glu	Ala	Tyr	Asp	Phe	Ile	Pro
Thr	Ser	Met	Asp	Pro	Pro	Glu	Gln	Arg	Gln	Phe	Arg	Ala	Leu	Ala	Asn	Gln	Val	Val	Gly	Met	Pro	Val	Val	Asp
Lys	Leu	Glu	Asn	Arg	Ile	Gln	Glu	Leu	Ala	Cys	Ser	Leu	Ile	Glu	Ser	Leu	Arg	Pro	Gln	Gly	Gln	Cys	Asn	Phe
Thr	Glu	Asp	Tyr	Ala	Glu	Pro	Phe	Pro	Ile	Arg	Ile	Phe	Met	Leu	Leu	Ala	Gly	Leu	Pro	Glu	Glu	Asp	Ile	Pro
His	Leu	Lys	Tyr	Leu	Thr	Asp	Gln	Met	Thr	Arg	Pro	Asp	Gly	Ser	Met	Thr	Phe	Ala	Glu	Ala	Lys	Glu	Ala	Leu
Tyr	Asp	Tyr	Leu	Ile	Pro	Ile	Ile	Glu	Gln	Arg	Arg	Gln	Lys	Pro	Gly	Thr	Asp	Ala	Ile	Ser	Ile	Val	Ala	Asn
Gly	Gln	Val	Asn	Gly	Arg	Pro	Ile	Thr	Ser	Asp	Glu	Ala	Lys	Arg	Met	Cys	Gly	Leu	Leu	Leu	Val	Gly	Gly	Leu
Asp	Thr	Val	Val	Asn	Phe	Leu	Ser	Phe	Ser	Met	Glu	Phe	Leu	Ala	Lys	Ser	Pro	Glu	His	Arg	Gln	Glu	Leu	Ile
Gln	Arg	Pro	Glu	Arg	Ile	Pro	Ala	Ala	Cys	Glu	Glu	Leu	Leu	Arg	Arg	Phe	Ser	Leu	Val	Ala	Asp	Gly	Arg	Ile
Leu	Thr	Ser	Asp	Tyr	Glu	Phe	His	Gly	Val	Gln	Leu	Lys	Lys	Gly	Asp	Gln	Ile	Leu	Leu	Pro	Gln	Met	Leu	Ser
Gly	Leu	Asp	Glu	Arg	Glu	Asn	Ala	Cys	Pro	Met	His	Val	Asp	Phe	Ser	Arg	Gln	Lys	Val	Ser	His	Thr	Thr	Phe
Gly	His	Gly	Ser	His	Leu	Cys	Leu	Gly	Gln	His	Leu	Ala	Arg	Arg	Glu	Ile	Ile	Val	Thr	Leu	Lys	Glu	Trp	Leu
Thr	Arg	Ile	Pro	Asp	Phe	Ser	Ile	Ala	Pro	Gly	Ala	Gln	Ile	Gln	His	Lys	Ser	Gly	Ile	Val	Ser	Gly	Val	Gln
Ala	Leu	Pro	Leu	Val	Trp	Asp	Pro	Ala	Thr	Thr	Lys	Ala	Val

Met	Ser	Lys	Gly	Glu	Glu	Leu	Phe	Thr	Gly	Val	Val	Pro	Ile	Leu	Val	Glu	Leu	Asp	Gly	Asp	Val	Asn	Gly	His
Lys	Phe	Ser	Val	Ser	Gly	Glu	Gly	Glu	Gly	Asp	Ala	Thr	Tyr	Gly	Lys	Leu	Thr	Leu	Lys	Phe	Ile	Cys	Thr	Thr
Gly	Lys	Leu	Pro	Val	Pro	Trp	Pro	Thr	Leu	Val	Thr	Thr	Phe	Ser	Tyr	Gly	Val	Gln	Cys	Phe	Ser	Arg	Tyr	Pro
Asp	His	Met	Lys	Arg	His	Asp	Phe	Phe	Lys	Ser	Ala	Met	Pro	Glu	Gly	Tyr	Val	Gln	Glu	Arg	Thr	Ile	Phe	Phe
Lys	Asp	Asp	Gly	Asn	Tyr	Lys	Thr	Arg	Ala	Glu	Val	Lys	Phe	Glu	Gly	Asp	Thr	Leu	Val	Asn	Arg	Ile	Glu	Leu
Lys	Gly	Ile	Asp	Phe	Lys	Glu	Asp	Gly	Asn	Ile	Leu	Gly	His	Lys	Leu	Glu	Tyr	Asn	Tyr	Asn	Ser	His	Asn	Val
Tyr	Ile	Met	Ala	Asp	Lys	Gln	Lys	Asn	Gly	Ile	Lys	Val	Asn	Phe	Lys	Ile	Arg	His	Asn	Ile	Glu	Asp	Gly	Ser
Val	Gln	Leu	Ala	Asp	His	Tyr	Gln	Gln	Asn	Thr	Pro	Ile	Gly	Asp	Gly	Pro	Val	Leu	Leu	Pro	Asp	Asn	His	Tyr
Leu	Ser	Thr	Gln	Ser	Ala	Leu	Ser	Lys	Asp	Pro	Asn	Glu	Lys	Arg	Asp	His	Met	Val	Leu	Leu	Glu	Phe	Val	Thr
Ala	Ala	Gly	Ile	Thr	His	Gly	Met	Asp	Glu	Leu	Tyr	Lys

Ala	Leu	His	Trp	Arg	Ala	Ala	Gly	Ala	Ala	Thr	Val	Leu	Leu	Val	Ile	Val	Leu	Leu	Ala	Gly	Ser	Tyr	Leu	Ala
Val	Leu	Ala	Glu	Arg	Gly	Ala	Pro	Gly	Ala	Gln	Leu	Ile	Thr	Tyr	Pro	Arg	Ala	Leu	Trp	Trp	Ser	Val	Glu	Thr
Ala	Thr	Thr	Val	Gly	Tyr	Gly	Asp	Leu	Tyr	Pro	Val	Thr	Leu	Trp	Gly	Arg	Cys	Val	Ala	Val	Val	Val	Met	Val
Ala	Gly	Ile	Thr	Ser	Phe	Gly	Leu	Val	Thr	Ala	Ala	Leu	Ala	Thr	Trp	Phe	Val	Gly	Arg	Glu	Gln

Glu	Pro	Cys	Val	Glu	Val	Val	Pro	Asn	Ile	Thr	Tyr	Gln	Cys	Met	Glu	Leu	Asn	Phe	Tyr	Lys	Ile	Pro	Asp	Asn
Leu	Pro	Phe	Ser	Thr	Lys	Asn	Leu	Asp	Leu	Ser	Phe	Asn	Pro	Leu	Arg	His	Leu	Gly	Ser	Tyr	Ser	Phe	Phe	Ser
Phe	Pro	Glu	Leu	Gln	Val	Leu	Asp	Leu	Ser	Arg	Cys	Glu	Ile	Gln	Thr	Ile	Glu	Asp	Gly	Ala	Tyr	Gln	Ser	Leu
Ser	His	Leu	Ser	Thr	Leu	Ile	Leu	Thr	Gly	Asn	Pro	Ile	Gln	Ser	Leu	Ala	Leu	Gly	Ala	Phe	Ser	Gly	Leu	Ser
Ser	Leu	Gln	Lys	Leu	Val	Ala	Val	Glu	Thr	Asn	Leu	Ala	Ser	Leu	Glu	Asn	Phe	Pro	Ile	Gly	His	Leu	Lys	Thr
Leu	Lys	Glu	Leu	Asn	Val	Ala	His	Asn	Leu	Ile	Gln	Ser	Phe	Lys	Leu	Pro	Glu	Tyr	Phe	Ser	Asn	Leu	Thr	Asn
Leu	Glu	His	Leu	Asp	Leu	Ser	Ser	Asn	Lys	Ile	Gln	Ser	Ile	Tyr	Cys	Thr	Asp	Leu	Arg	Val	Leu	His	Gln	Met
Pro	Leu	Leu	Asn	Leu	Ser	Leu	Asp	Leu	Ser	Leu	Asn	Pro	Met	Asn	Phe	Ile	Gln	Pro	Gly	Ala	Phe	Lys	Glu	Ile
Arg	Leu	His	Lys	Leu	Thr	Leu	Arg	Asn	Asn	Phe	Asp	Ser	Leu	Asn	Val	Met	Lys	Thr	Cys	Ile	Gln	Gly	Leu	Ala
Gly	Leu	Glu	Val	His	Arg	Leu	Val	Leu	Gly	Glu	Phe	Arg	Asn	Glu	Gly	Asn	Leu	Glu	Lys	Phe	Asp	Lys	Ser	Ala
Leu	Glu	Gly	Leu	Cys	Asn	Leu	Thr	Ile	Glu	Glu	Phe	Arg	Leu	Ala	Tyr	Leu	Asp	Tyr	Tyr	Leu	Asp	Asp	Ile	Ile
Asp	Leu	Phe	Asn	Cys	Leu	Thr	Asn	Val	Ser	Ser	Phe	Ser	Leu	Val	Ser	Val	Thr	Ile	Glu	Arg	Val	Lys	Asp	Phe
Ser	Tyr	Asn	Phe	Gly	Trp	Gln	His	Leu	Glu	Leu	Val	Asn	Cys	Lys	Phe	Gly	Gln	Phe	Pro	Thr	Leu	Lys	Leu	Lys
Ser	Leu	Lys	Arg	Leu	Thr	Phe	Thr	Ser	Asn	Lys	Gly	Gly	Asn	Ala	Phe	Ser	Glu	Val	Asp	Leu	Pro	Ser	Leu	Glu
Phe	Leu	Asp	Leu	Ser	Arg	Asn	Gly	Leu	Ser	Phe	Lys	Gly	Cys	Cys	Ser	Gln	Ser	Asp	Phe	Gly	Thr	Thr	Ser	Leu
Lys	Tyr	Leu	Asp	Leu	Ser	Phe	Asn	Gly	Val	Ile	Thr	Met	Ser	Ser	Asn	Phe	Leu	Gly	Leu	Glu	Gln	Leu	Glu	His
Leu	Asp	Phe	Gln	His	Ser	Asn	Leu	Lys	Gln	Met	Ser	Glu	Phe	Ser	Val	Phe	Leu	Ser	Leu	Arg	Asn	Leu	Ile	Tyr
Leu	Asp	Ile	Ser	His	Thr	His	Thr	Arg	Val	Ala	Phe	Asn	Gly	Ile	Phe	Asn	Gly	Leu	Ser	Ser	Leu	Glu	Val	Leu
Lys	Met	Ala	Gly	Asn	Ser	Phe	Gln	Glu	Asn	Phe	Leu	Pro	Asp	Ile	Phe	Thr	Glu	Leu	Arg	Asn	Leu	Thr	Phe	Leu
Asp	Leu	Ser	Gln	Cys	Gln	Leu	Glu	Gln	Leu	Ser	Pro	Thr	Ala	Phe	Asn	Ser	Leu	Ser	Ser	Leu	Gln	Val	Leu	Asn
Met	Ser	His	Asn	Asn	Phe	Phe	Ser	Leu	Asp	Thr	Phe	Pro	Tyr	Lys	Cys	Leu	Asn	Ser	Leu	Gln	Val	Leu	Asp	Tyr
Ser	Leu	Asn	His	Ile	Met	Thr	Ser	Lys	Lys	Gln	Glu	Leu	Gln	His	Phe	Pro	Ser	Ser	Leu	Ala	Phe	Leu	Asn	Leu
Thr	Gln	Asn	Asp	Phe	Ala	Cys	Thr	Cys	Glu	His	Gln	Ser	Phe	Leu	Gln	Trp	Ile	Lys	Asp	Gln	Arg	Gln	Leu	Leu
Val	Glu	Val	Glu	Arg	Met	Glu	Cys	Ala	Thr	Pro	Ser	Asp	Lys	Gln	Gly	Met	Pro	Val	Leu	Ser	Leu	Asn	Ile	Thr
Cys	Gln	Met	Asn	Lys

Met	Lys	Arg	Arg	Ile	Arg	Arg	Glu	Arg	Asn	Lys	Met	Ala	Ala	Ala	Lys	Ser	Arg	Asn	Arg	Arg	Arg	Glu	Leu	Thr
Asp	Thr	Leu	Gln	Ala	Glu	Thr	Asp	Gln	Leu	Glu	Asp	Glu	Lys	Ser	Ala	Leu	Gln	Thr	Glu	Ile	Ala	Asn	Leu	Leu
Lys	Glu	Lys	Glu	Lys	Leu

Val	Leu	Ser	Pro	Ala	Asp	Lys	Thr	Asn	Val	Lys	Ala	Ala	Trp	Gly	Lys	Val	Gly	Ala	His	Ala	Gly	Glu	Tyr	Gly
Ala	Glu	Ala	Leu	Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Thr	Thr	Lys	Thr	Tyr	Phe	Pro	His	Phe	Asp	Leu	Ser	His
Gly	Ser	Ala	Gln	Val	Lys	Gly	His	Gly	Lys	Lys	Val	Ala	Asp	Ala	Leu	Thr	Asn	Ala	Val	Ala	His	Val	Asp	Asp
Met	Pro	Asn	Ala	Leu	Ser	Ala	Leu	Ser	Asp	Leu	His	Ala	His	Lys	Leu	Arg	Val	Asp	Pro	Val	Asn	Phe	Lys	Leu
Leu	Ser	His	Cys	Leu	Leu	Val	Thr	Leu	Ala	Ala	His	Leu	Pro	Ala	Glu	Phe	Thr	Pro	Ala	Val	His	Ala	Ser	Leu
Asp	Lys	Phe	Leu	Ala	Ser	Val	Ser	Thr	Val	Leu	Thr	Ser	Lys	Tyr	Arg

Thr	Thr	Glu	Thr	Ile	Gln	Ser	Asn	Ala	Asn	Leu	Ala	Pro	Leu	Pro	Pro	His	Val	Pro	Glu	His	Leu	Val	Phe	Asp
Phe	Asp	Met	Tyr	Asn	Pro	Ser	Asn	Leu	Ser	Ala	Gly	Val	Gln	Glu	Ala	Trp	Ala	Val	Leu	Gln	Glu	Ser	Asn	Val
Pro	Asp	Leu	Val	Trp	Thr	Arg	Cys	Asn	Gly	Gly	His	Trp	Ile	Ala	Thr	Arg	Gly	Gln	Leu	Ile	Arg	Glu	Ala	Tyr
Glu	Asp	Tyr	Arg	His	Phe	Ser	Ser	Glu	Cys	Pro	Phe	Ile	Pro	Arg	Glu	Ala	Gly	Glu	Ala	Tyr	Asp	Phe	Ile	Pro
Thr	Ser	Met	Asp	Pro	Pro	Glu	Gln	Arg	Gln	Phe	Arg	Ala	Leu	Ala	Asn	Gln	Val	Val	Gly	Met	Pro	Val	Val	Asp
Lys	Leu	Glu	Asn	Arg	Ile	Gln	Glu	Leu	Ala	Cys	Ser	Leu	Ile	Glu	Ser	Leu	Arg	Pro	Gln	Gly	Gln	Cys	Asn	Phe
Thr	Glu	Asp	Tyr	Ala	Glu	Pro	Phe	Pro	Ile	Arg	Ile	Phe	Met	Leu	Leu	Ala	Gly	Leu	Pro	Glu	Glu	Asp	Ile	Pro
His	Leu	Lys	Tyr	Leu	Thr	Asp	Gln	Met	Thr	Arg	Pro	Asp	Gly	Ser	Met	Thr	Phe	Ala	Glu	Ala	Lys	Glu	Ala	Leu
Tyr	Asp	Tyr	Leu	Ile	Pro	Ile	Ile	Glu	Gln	Arg	Arg	Gln	Lys	Pro	Gly	Thr	Asp	Ala	Ile	Ser	Ile	Val	Ala	Asn
Gly	Gln	Val	Asn	Gly	Arg	Pro	Ile	Thr	Ser	Asp	Glu	Ala	Lys	Arg	Met	Cys	Gly	Leu	Leu	Leu	Val	Gly	Gly	Leu
Asp	Thr	Val	Val	Asn	Phe	Leu	Ser	Phe	Ser	Met	Glu	Phe	Leu	Ala	Lys	Ser	Pro	Glu	His	Arg	Gln	Glu	Leu	Ile
Gln	Arg	Pro	Glu	Arg	Ile	Pro	Ala	Ala	Cys	Glu	Glu	Leu	Leu	Arg	Arg	Phe	Ser	Leu	Val	Ala	Asp	Gly	Arg	Ile
Leu	Thr	Ser	Asp	Tyr	Glu	Phe	His	Gly	Val	Gln	Leu	Lys	Lys	Gly	Asp	Gln	Ile	Leu	Leu	Pro	Gln	Met	Leu	Ser
Gly	Leu	Asp	Glu	Arg	Glu	Asn	Ala	Cys	Pro	Met	His	Val	Asp	Phe	Ser	Arg	Gln	Lys	Val	Ser	His	Thr	Thr	Phe
Gly	His	Gly	Ser	His	Leu	Cys	Leu	Gly	Gln	His	Leu	Ala	Arg	Arg	Glu	Ile	Ile	Val	Thr	Leu	Lys	Glu	Trp	Leu
Thr	Arg	Ile	Pro	Asp	Phe	Ser	Ile	Ala	Pro	Gly	Ala	Gln	Ile	Gln	His	Lys	Ser	Gly	Ile	Val	Ser	Gly	Val	Gln
Ala	Leu	Pro	Leu	Val	Trp	Asp	Pro	Ala	Thr	Thr	Lys	Ala	Val

Met	Ser	Lys	Gly	Glu	Glu	Leu	Phe	Thr	Gly	Val	Val	Pro	Ile	Leu	Val	Glu	Leu	Asp	Gly	Asp	Val	Asn	Gly	His
Lys	Phe	Ser	Val	Ser	Gly	Glu	Gly	Glu	Gly	Asp	Ala	Thr	Tyr	Gly	Lys	Leu	Thr	Leu	Lys	Phe	Ile	Cys	Thr	Thr
Gly	Lys	Leu	Pro	Val	Pro	Trp	Pro	Thr	Leu	Val	Thr	Thr	Phe	Ser	Tyr	Gly	Val	Gln	Cys	Phe	Ser	Arg	Tyr	Pro
Asp	His	Met	Lys	Arg	His	Asp	Phe	Phe	Lys	Ser	Ala	Met	Pro	Glu	Gly	Tyr	Val	Gln	Glu	Arg	Thr	Ile	Phe	Phe
Lys	Asp	Asp	Gly	Asn	Tyr	Lys	Thr	Arg	Ala	Glu	Val	Lys	Phe	Glu	Gly	Asp	Thr	Leu	Val	Asn	Arg	Ile	Glu	Leu
Lys	Gly	Ile	Asp	Phe	Lys	Glu	Asp	Gly	Asn	Ile	Leu	Gly	His	Lys	Leu	Glu	Tyr	Asn	Tyr	Asn	Ser	His	Asn	Val
Tyr	Ile	Met	Ala	Asp	Lys	Gln	Lys	Asn	Gly	Ile	Lys	Val	Asn	Phe	Lys	Ile	Arg	His	Asn	Ile	Glu	Asp	Gly	Ser
Val	Gln	Leu	Ala	Asp	His	Tyr	Gln	Gln	Asn	Thr	Pro	Ile	Gly	Asp	Gly	Pro	Val	Leu	Leu	Pro	Asp	Asn	His	Tyr
Leu	Ser	Thr	Gln	Ser	Ala	Leu	Ser	Lys	Asp	Pro	Asn	Glu	Lys	Arg	Asp	His	Met	Val	Leu	Leu	Glu	Phe	Val	Thr
Ala	Ala	Gly	Ile	Thr	His	Gly	Met	Asp	Glu	Leu	Tyr	Lys

Ala	Leu	His	Trp	Arg	Ala	Ala	Gly	Ala	Ala	Thr	Val	Leu	Leu	Val	Ile	Val	Leu	Leu	Ala	Gly	Ser	Tyr	Leu	Ala
Val	Leu	Ala	Glu	Arg	Gly	Ala	Pro	Gly	Ala	Gln	Leu	Ile	Thr	Tyr	Pro	Arg	Ala	Leu	Trp	Trp	Ser	Val	Glu	Thr
Ala	Thr	Thr	Val	Gly	Tyr	Gly	Asp	Leu	Tyr	Pro	Val	Thr	Leu	Trp	Gly	Arg	Cys	Val	Ala	Val	Val	Val	Met	Val
Ala	Gly	Ile	Thr	Ser	Phe	Gly	Leu	Val	Thr	Ala	Ala	Leu	Ala	Thr	Trp	Phe	Val	Gly	Arg	Glu	Gln

Glu	Pro	Cys	Val	Glu	Val	Val	Pro	Asn	Ile	Thr	Tyr	Gln	Cys	Met	Glu	Leu	Asn	Phe	Tyr	Lys	Ile	Pro	Asp	Asn
Leu	Pro	Phe	Ser	Thr	Lys	Asn	Leu	Asp	Leu	Ser	Phe	Asn	Pro	Leu	Arg	His	Leu	Gly	Ser	Tyr	Ser	Phe	Phe	Ser
Phe	Pro	Glu	Leu	Gln	Val	Leu	Asp	Leu	Ser	Arg	Cys	Glu	Ile	Gln	Thr	Ile	Glu	Asp	Gly	Ala	Tyr	Gln	Ser	Leu
Ser	His	Leu	Ser	Thr	Leu	Ile	Leu	Thr	Gly	Asn	Pro	Ile	Gln	Ser	Leu	Ala	Leu	Gly	Ala	Phe	Ser	Gly	Leu	Ser
Ser	Leu	Gln	Lys	Leu	Val	Ala	Val	Glu	Thr	Asn	Leu	Ala	Ser	Leu	Glu	Asn	Phe	Pro	Ile	Gly	His	Leu	Lys	Thr
Leu	Lys	Glu	Leu	Asn	Val	Ala	His	Asn	Leu	Ile	Gln	Ser	Phe	Lys	Leu	Pro	Glu	Tyr	Phe	Ser	Asn	Leu	Thr	Asn
Leu	Glu	His	Leu	Asp	Leu	Ser	Ser	Asn	Lys	Ile	Gln	Ser	Ile	Tyr	Cys	Thr	Asp	Leu	Arg	Val	Leu	His	Gln	Met
Pro	Leu	Leu	Asn	Leu	Ser	Leu	Asp	Leu	Ser	Leu	Asn	Pro	Met	Asn	Phe	Ile	Gln	Pro	Gly	Ala	Phe	Lys	Glu	Ile
Arg	Leu	His	Lys	Leu	Thr	Leu	Arg	Asn	Asn	Phe	Asp	Ser	Leu	Asn	Val	Met	Lys	Thr	Cys	Ile	Gln	Gly	Leu	Ala
Gly	Leu	Glu	Val	His	Arg	Leu	Val	Leu	Gly	Glu	Phe	Arg	Asn	Glu	Gly	Asn	Leu	Glu	Lys	Phe	Asp	Lys	Ser	Ala
Leu	Glu	Gly	Leu	Cys	Asn	Leu	Thr	Ile	Glu	Glu	Phe	Arg	Leu	Ala	Tyr	Leu	Asp	Tyr	Tyr	Leu	Asp	Asp	Ile	Ile
Asp	Leu	Phe	Asn	Cys	Leu	Thr	Asn	Val	Ser	Ser	Phe	Ser	Leu	Val	Ser	Val	Thr	Ile	Glu	Arg	Val	Lys	Asp	Phe
Ser	Tyr	Asn	Phe	Gly	Trp	Gln	His	Leu	Glu	Leu	Val	Asn	Cys	Lys	Phe	Gly	Gln	Phe	Pro	Thr	Leu	Lys	Leu	Lys
Ser	Leu	Lys	Arg	Leu	Thr	Phe	Thr	Ser	Asn	Lys	Gly	Gly	Asn	Ala	Phe	Ser	Glu	Val	Asp	Leu	Pro	Ser	Leu	Glu
Phe	Leu	Asp	Leu	Ser	Arg	Asn	Gly	Leu	Ser	Phe	Lys	Gly	Cys	Cys	Ser	Gln	Ser	Asp	Phe	Gly	Thr	Thr	Ser	Leu
Lys	Tyr	Leu	Asp	Leu	Ser	Phe	Asn	Gly	Val	Ile	Thr	Met	Ser	Ser	Asn	Phe	Leu	Gly	Leu	Glu	Gln	Leu	Glu	His
Leu	Asp	Phe	Gln	His	Ser	Asn	Leu	Lys	Gln	Met	Ser	Glu	Phe	Ser	Val	Phe	Leu	Ser	Leu	Arg	Asn	Leu	Ile	Tyr
Leu	Asp	Ile	Ser	His	Thr	His	Thr	Arg	Val	Ala	Phe	Asn	Gly	Ile	Phe	Asn	Gly	Leu	Ser	Ser	Leu	Glu	Val	Leu
Lys	Met	Ala	Gly	Asn	Ser	Phe	Gln	Glu	Asn	Phe	Leu	Pro	Asp	Ile	Phe	Thr	Glu	Leu	Arg	Asn	Leu	Thr	Phe	Leu
Asp	Leu	Ser	Gln	Cys	Gln	Leu	Glu	Gln	Leu	Ser	Pro	Thr	Ala	Phe	Asn	Ser	Leu	Ser	Ser	Leu	Gln	Val	Leu	Asn
Met	Ser	His	Asn	Asn	Phe	Phe	Ser	Leu	Asp	Thr	Phe	Pro	Tyr	Lys	Cys	Leu	Asn	Ser	Leu	Gln	Val	Leu	Asp	Tyr
Ser	Leu	Asn	His	Ile	Met	Thr	Ser	Lys	Lys	Gln	Glu	Leu	Gln	His	Phe	Pro	Ser	Ser	Leu	Ala	Phe	Leu	Asn	Leu
Thr	Gln	Asn	Asp	Phe	Ala	Cys	Thr	Cys	Glu	His	Gln	Ser	Phe	Leu	Gln	Trp	Ile	Lys	Asp	Gln	Arg	Gln	Leu	Leu
Val	Glu	Val	Glu	Arg	Met	Glu	Cys	Ala	Thr	Pro	Ser	Asp	Lys	Gln	Gly	Met	Pro	Val	Leu	Ser	Leu	Asn	Ile	Thr
Cys	Gln	Met	Asn	Lys

Met	Lys	Arg	Arg	Ile	Arg	Arg	Glu	Arg	Asn	Lys	Met	Ala	Ala	Ala	Lys	Ser	Arg	Asn	Arg	Arg	Arg	Glu	Leu	Thr
Asp	Thr	Leu	Gln	Ala	Glu	Thr	Asp	Gln	Leu	Glu	Asp	Glu	Lys	Ser	Ala	Leu	Gln	Thr	Glu	Ile	Ala	Asn	Leu	Leu
Lys	Glu	Lys	Glu	Lys	Leu

Val	Leu	Ser	Pro	Ala	Asp	Lys	Thr	Asn	Val	Lys	Ala	Ala	Trp	Gly	Lys	Val	Gly	Ala	His	Ala	Gly	Glu	Tyr	Gly
Ala	Glu	Ala	Leu	Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Thr	Thr	Lys	Thr	Tyr	Phe	Pro	His	Phe	Asp	Leu	Ser	His
Gly	Ser	Ala	Gln	Val	Lys	Gly	His	Gly	Lys	Lys	Val	Ala	Asp	Ala	Leu	Thr	Asn	Ala	Val	Ala	His	Val	Asp	Asp
Met	Pro	Asn	Ala	Leu	Ser	Ala	Leu	Ser	Asp	Leu	His	Ala	His	Lys	Leu	Arg	Val	Asp	Pro	Val	Asn	Phe	Lys	Leu
Leu	Ser	His	Cys	Leu	Leu	Val	Thr	Leu	Ala	Ala	His	Leu	Pro	Ala	Glu	Phe	Thr	Pro	Ala	Val	His	Ala	Ser	Leu
Asp	Lys	Phe	Leu	Ala	Ser	Val	Ser	Thr	Val	Leu	Thr	Ser	Lys	Tyr	Arg

Thr	Thr	Glu	Thr	Ile	Gln	Ser	Asn	Ala	Asn	Leu	Ala	Pro	Leu	Pro	Pro	His	Val	Pro	Glu	His	Leu	Val	Phe	Asp
Phe	Asp	Met	Tyr	Asn	Pro	Ser	Asn	Leu	Ser	Ala	Gly	Val	Gln	Glu	Ala	Trp	Ala	Val	Leu	Gln	Glu	Ser	Asn	Val
Pro	Asp	Leu	Val	Trp	Thr	Arg	Cys	Asn	Gly	Gly	His	Trp	Ile	Ala	Thr	Arg	Gly	Gln	Leu	Ile	Arg	Glu	Ala	Tyr
Glu	Asp	Tyr	Arg	His	Phe	Ser	Ser	Glu	Cys	Pro	Phe	Ile	Pro	Arg	Glu	Ala	Gly	Glu	Ala	Tyr	Asp	Phe	Ile	Pro
Thr	Ser	Met	Asp	Pro	Pro	Glu	Gln	Arg	Gln	Phe	Arg	Ala	Leu	Ala	Asn	Gln	Val	Val	Gly	Met	Pro	Val	Val	Asp
Lys	Leu	Glu	Asn	Arg	Ile	Gln	Glu	Leu	Ala	Cys	Ser	Leu	Ile	Glu	Ser	Leu	Arg	Pro	Gln	Gly	Gln	Cys	Asn	Phe
Thr	Glu	Asp	Tyr	Ala	Glu	Pro	Phe	Pro	Ile	Arg	Ile	Phe	Met	Leu	Leu	Ala	Gly	Leu	Pro	Glu	Glu	Asp	Ile	Pro
His	Leu	Lys	Tyr	Leu	Thr	Asp	Gln	Met	Thr	Arg	Pro	Asp	Gly	Ser	Met	Thr	Phe	Ala	Glu	Ala	Lys	Glu	Ala	Leu
Tyr	Asp	Tyr	Leu	Ile	Pro	Ile	Ile	Glu	Gln	Arg	Arg	Gln	Lys	Pro	Gly	Thr	Asp	Ala	Ile	Ser	Ile	Val	Ala	Asn
Gly	Gln	Val	Asn	Gly	Arg	Pro	Ile	Thr	Ser	Asp	Glu	Ala	Lys	Arg	Met	Cys	Gly	Leu	Leu	Leu	Val	Gly	Gly	Leu
Asp	Thr	Val	Val	Asn	Phe	Leu	Ser	Phe	Ser	Met	Glu	Phe	Leu	Ala	Lys	Ser	Pro	Glu	His	Arg	Gln	Glu	Leu	Ile
Gln	Arg	Pro	Glu	Arg	Ile	Pro	Ala	Ala	Cys	Glu	Glu	Leu	Leu	Arg	Arg	Phe	Ser	Leu	Val	Ala	Asp	Gly	Arg	Ile
Leu	Thr	Ser	Asp	Tyr	Glu	Phe	His	Gly	Val	Gln	Leu	Lys	Lys	Gly	Asp	Gln	Ile	Leu	Leu	Pro	Gln	Met	Leu	Ser
Gly	Leu	Asp	Glu	Arg	Glu	Asn	Ala	Cys	Pro	Met	His	Val	Asp	Phe	Ser	Arg	Gln	Lys	Val	Ser	His	Thr	Thr	Phe
Gly	His	Gly	Ser	His	Leu	Cys	Leu	Gly	Gln	His	Leu	Ala	Arg	Arg	Glu	Ile	Ile	Val	Thr	Leu	Lys	Glu	Trp	Leu
Thr	Arg	Ile	Pro	Asp	Phe	Ser	Ile	Ala	Pro	Gly	Ala	Gln	Ile	Gln	His	Lys	Ser	Gly	Ile	Val	Ser	Gly	Val	Gln
Ala	Leu	Pro	Leu	Val	Trp	Asp	Pro	Ala	Thr	Thr	Lys	Ala	Val

Met	Ser	Lys	Gly	Glu	Glu	Leu	Phe	Thr	Gly	Val	Val	Pro	Ile	Leu	Val	Glu	Leu	Asp	Gly	Asp	Val	Asn	Gly	His
Lys	Phe	Ser	Val	Ser	Gly	Glu	Gly	Glu	Gly	Asp	Ala	Thr	Tyr	Gly	Lys	Leu	Thr	Leu	Lys	Phe	Ile	Cys	Thr	Thr
Gly	Lys	Leu	Pro	Val	Pro	Trp	Pro	Thr	Leu	Val	Thr	Thr	Phe	Ser	Tyr	Gly	Val	Gln	Cys	Phe	Ser	Arg	Tyr	Pro
Asp	His	Met	Lys	Arg	His	Asp	Phe	Phe	Lys	Ser	Ala	Met	Pro	Glu	Gly	Tyr	Val	Gln	Glu	Arg	Thr	Ile	Phe	Phe
Lys	Asp	Asp	Gly	Asn	Tyr	Lys	Thr	Arg	Ala	Glu	Val	Lys	Phe	Glu	Gly	Asp	Thr	Leu	Val	Asn	Arg	Ile	Glu	Leu
Lys	Gly	Ile	Asp	Phe	Lys	Glu	Asp	Gly	Asn	Ile	Leu	Gly	His	Lys	Leu	Glu	Tyr	Asn	Tyr	Asn	Ser	His	Asn	Val
Tyr	Ile	Met	Ala	Asp	Lys	Gln	Lys	Asn	Gly	Ile	Lys	Val	Asn	Phe	Lys	Ile	Arg	His	Asn	Ile	Glu	Asp	Gly	Ser
Val	Gln	Leu	Ala	Asp	His	Tyr	Gln	Gln	Asn	Thr	Pro	Ile	Gly	Asp	Gly	Pro	Val	Leu	Leu	Pro	Asp	Asn	His	Tyr
Leu	Ser	Thr	Gln	Ser	Ala	Leu	Ser	Lys	Asp	Pro	Asn	Glu	Lys	Arg	Asp	His	Met	Val	Leu	Leu	Glu	Phe	Val	Thr
Ala	Ala	Gly	Ile	Thr	His	Gly	Met	Asp	Glu	Leu	Tyr	Lys

Ala	Leu	His	Trp	Arg	Ala	Ala	Gly	Ala	Ala	Thr	Val	Leu	Leu	Val	Ile	Val	Leu	Leu	Ala	Gly	Ser	Tyr	Leu	Ala
Val	Leu	Ala	Glu	Arg	Gly	Ala	Pro	Gly	Ala	Gln	Leu	Ile	Thr	Tyr	Pro	Arg	Ala	Leu	Trp	Trp	Ser	Val	Glu	Thr
Ala	Thr	Thr	Val	Gly	Tyr	Gly	Asp	Leu	Tyr	Pro	Val	Thr	Leu	Trp	Gly	Arg	Cys	Val	Ala	Val	Val	Val	Met	Val
Ala	Gly	Ile	Thr	Ser	Phe	Gly	Leu	Val	Thr	Ala	Ala	Leu	Ala	Thr	Trp	Phe	Val	Gly	Arg	Glu	Gln