◆ ヘモグロビン ◆
《 旧タイトル:ヘモグロビンとヘモグロビンS 》
旧版データ更新しない別版放送大学「分子の科学」版(多くの機種で参照可)Chime版


オキシヘモグロビンとデオキシヘモグロビンいろいろな生物のヘモグロビンアミノ酸配列比較ヘモグロビンS参考資料

●オキシヘモグロビンとデオキシヘモグロビン 初期表示はデオキシヘモグロビンの2HHB;4量体

バックボーン 二次構造
全選択 タンパク質選択 リガンド選択 ヘム選択 Fe選択 酸素O2選択
(*印のみ) HB選択($印のみ)
Chain A選択 B C D
空間充填 球棒 球10% 球30% 球60% スティック(太) 針金 消去
アミノ色 Chain色 CPK色 ‖ Jmol色 Rasmol色 ‖ 濃赤 濃青  濃ピンク 
糖鎖別着色(#印のみ)Galα-Glcβ-GlcManFucXylSiaGalNAcGlcNAcGlcA
酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックスβストランド) ヒトの必須・非必須区別
水素結合表示S-S結合表示   
背景・黒 灰 白 
◎オキシヘモグロビン
1HHO A鎖(ヘモグロビンα) 同4量体(A・B鎖×2) → Jmolトピック(AlphaFold構造との比較)
PDBsum1hho_HEM-OXY(A鎖;ヘモグロビンα)$ 1hho_HEM-OXY(B鎖;ヘモグロビンβ)$
◎デオキシヘモグロビン
4HHB A鎖(ヘモグロビンα) 同 B鎖(ヘモグロビンβ) | 2HHB A鎖(ヘモグロビンα) 同4量体
PDBsum2hhb_HEM(A鎖) $ 2hhb_HEM(B鎖;ヘモグロビンβ)$
5KDQ(3-[2-chloranyl-4-(1~{H}-imidazol-2-yl)phenoxy]propanoic acidが結合したデオキシヘモグロビン) → Jmolトピック

※胎児ヘモグロビンHbF
4MQJ F鎖(胎児ヘモグロビンHbFのヘモグロビンγ;オキシヘモグロビン) 同 C-F鎖(4量体) 同 A-H鎖(8量体) 
成人のヘモグロビンHbA(α2β2)と胎児ヘモグロビンHbF(α2γ2)の比較(上:1HHOのA鎖〈α〉とB鎖〈β〉 下:4MQJのE鎖〈α〉とF鎖〈γ〉)
PDBsumデータ比較(何れもO2結合): 1hho_HEM-OXY(ヘモグロビンβ,B鎖;再掲)$ 4mqj_HEM-OXY(ヘモグロビンγ,F鎖)$
1FDH(胎児ヘモグロビンHbF:α2γ2) → PDBj今月の分子 257: 胎児ヘモグロビン(Fetal Hemoglobin)Jmolトピック
※糖化ヘモグロビンの例
3b75のChain A-D(ヒト,糖化ヘモグロビン) GLC(グルコース)選択 FRU(フルクトース)選択 Chain AのFRUとその結合アミノ酸残基Lys 99選択 同糖化アミノ酸部分3b75_FRU(Chain A) COC(コカイン)選択  同PDBsumデータ3b75_FRU$ → Jmolトピック
※Ni(II)-Fe(II)混成ヘモグロビンの例
6kaeのChain A-D(一酸化炭素が結合した Ni(II)-Fe(II)混成ヘモグロビン) CMO(一酸化炭素)選択 Fe・Ni選択 → Jmolトピック
※疾病に関係するヘモグロビンの例
4MQC(ヒト,カルボモノオキシヘモグロビン,4量体〈Chain A・B×2〉;自己免疫性溶血性貧血のEvans症候群に関係,V62M変異) 同Chain A 同PDBsum 4mqc_HEM-CMO(A鎖) $
※ヒトとヒト以外のヘモグロビンの比較
ヒト(2hhb,左),マンモス(3vrf,右)の比較(何れもA鎖)
ヒト(2hhb),マンモス(3vrf),シロザメ(1gcw),チューブワーム(1yhu)の比較(左上から時計回りで;何れもA鎖)
参考: ハツカネズミ(3hrw,左),マンモス(3vrf,右;CO結合)の比較(何れもA鎖)

◆ヘモグロビンSとヘモグロビン
ヘモグロビンSの2HBS B鎖(初期表示) Val6選択
ヘモグロビンの4HHB B鎖 Glu6選択
1aj9(ヒト,カルボモノオキシヘモグロビン,2量体,一酸化炭素が結合) 同Chain A 同PDBsum 1aj9_HEM-CMO(A鎖) $
2m6zのModel 1(ヒト,カルボモノオキシヘモグロビン,ヘムC;NMRによる) 同Chain A
3d7o*(ヒト,亜硝酸イオン NO2-結合)

3kmf*(ヒト,デオキシヘモグロビン;中性子回折による) PDBsum3kmf_HEMs(A鎖;PDBsumデータにH・D追加) $*

4m4a(ヒト,ニトロソメタン結合ヘモグロビン,2量体) PDBsum4m4a_HEM-NSM(A鎖) $

1buw(ヒト,一酸化窒素が結合したS-ニトロシル化ヘモグロビン,4量体) NO選択 SNC(L-ペプチド架橋)選択 同-S-N=O部分選択 同PDBsumデータ1buw_HEM-NO[HEM 142(A) to NO 143(A)] $ → Jmolトピック



アミノ酸および特性基の親水性・疎水性Log Pをポケットに!



オキシヘモグロビン1HHO(スティック表示)とデオキシヘモグロビン2HHB(針金表示)のPyMOLによる重ね合わせ表示(何れもChain AのPDBsumデータ)
※PyMOLによるPDBデータ重ね合わせ方法:中村春木 編,「見てわかる構造生命科学」,化学同人(2014),p.78


●いろいろな生物のヘモグロビンデータほか 初期表示はマンモス由来ヘモグロビン3VRF;2量体  ※その他参考:Jmolトピック

バックボーン 二次構造
全選択 タンパク質選択 リガンド選択 ヘム選択 Fe選択 酸素O2選択
(*印のみ) HB選択($印のみ)
Chain A選択 B C D
空間充填 球棒 球10% 球30% 球60% スティック(太) 針金 消去
アミノ色 Chain色 CPK色 ‖ Jmol色 Rasmol色 ‖ 濃赤 濃青  濃ピンク 
糖鎖別着色(#印のみ)Galα-Glcβ-GlcManFucXylSiaGalNAcGlcNAcGlcA
酸性・中性・塩基性区別 極性・非極性区別 疎水性インデックス順 I/O値順(特性基 R) 等電点順 コンホメーション選択性(αヘリックスβストランド) ヒトの必須・非必須区別
水素結合表示S-S結合表示   
背景・黒 灰 白 
◆マンモス由来ヘモグロビン
マンモス由来 3VRF(一酸化炭素が結合) 同Chain A 同PDBsum 3vrf_HEM-CMO(A鎖) $ [Mammoth - Wikipedia

◆ウマ由来ヘモグロビン
ウマ由来 6R2O同Chain A

◆ヒツジ由来ヘモグロビン
ヒツジ由来 2QU0

◆オオカミ由来ヘモグロビン
オオカミ(タテガミオオカミ)由来 1FHJのChain A

◆イヌ由来ヘモグロビン
イヌ(グレイハウンド)由来 3PELのChain A

◆ハツカネズミ由来ヘモグロビン
ハツカネズミ由来 3HRW  同Chain A 同PDBsum3hrw_HEM(A鎖) $

◆ワニ由来ヘモグロビン
ワニ由来 8WIZのChain B(重炭酸イオンが結合) 同PDBsum8wiz_BCT(B鎖) $
 → 大阪大学 蛋白質研究所プレスリリース(2024/08/06)Nature Communications誌論文 [NEW!]

◆ウズラ由来ヘモグロビン
ウズラ由来3MJP  同Chain A(オキシヘモグロビン) 同PDBsum3mjp_HEM-OXY(A鎖) $

◆クロマグロ由来ヘモグロビン
クロマグロ由来1V4W  同Chain A 同PDBsum1v4w_HEM(A鎖) $

◆シロザメ由来ヘモグロビン
シロザメ由来1GCW(一酸化炭素が結合)  同Chain A 同PDBsum1gcw_HEM-CMO(A鎖) $

◆ヤツメウナギ由来ヘモグロビン
ヤツメウナギ由来2LHB(シアン化物イオンが結合) 同PDBsum2lhb_CYN-HEM(A鎖) $

◆ヌタウナギ由来ヘモグロビン
ヌタウナギ由来1IT3(一酸化炭素が結合)  同Chain A 同PDBsum1it3_HEM-CMO(A鎖) $

◆チューブワーム由来ヘモグロビンとヒトヘモグロビンの大きさ比べ
チューブワーム由来1YHU  同Chain A 同PDBsum1yhu_HEM-OXY(A鎖) $
チューブワーム由来1YHU(左)とヒトヘモグロビン1HHO(4量体;右)
  → チューブワーム関連データのSITE例

◆サツマハオリムシ由来ヘモグロビン
チューブワームの一種サツマハオリムシ由来3WCT(24量体;A-H鎖×3)

◆マシコヒゲムシ由来ヘモグロビン
マシコヒゲムシ由来2D2N(24量体;A-D鎖×6) 同(4量体;A-D鎖)
PDBsum2d2n_MMC(メチル水銀,A鎖;A-D鎖で近傍アミノ酸に違い) $
  → SPring-8プレスリリース(2005/10/04)

◆アカムシユスリカ由来ヘモグロビン(ヘモグロビンV;Hb V)
アカムシユスリカ由来3ARK

◆シロイヌナズナ由来ヘモグロビン
シロイヌナズナ由来3ZHW  同Chain A 同PDBsum3zhw_HEM(A鎖) $

◆ダイズ由来ヘモグロビン(レグヘモグロビン)
ダイズ由来1BINのChain A(レグヘモグロビン) → Jmolトピック

◆細菌Vitreoscilla stercoraria由来ヘモグロビン
Vitreoscilla stercoraria由来2VHB(アジ化物イオンが結合)  同Chain A 同PDBsum2vhb_AZI-HEM(A鎖) $

【参考】
■“生物界で見られる4種類のテトラピロール”(岩波「科学」2013年7月号コラム,p.723図を参考に)

(a) クロロフィルa PDBデータ 3arcのChain A(光合成光化学系IIの部分構造) 同PDBsumデータ 3arc_CLA607s(多数のCLAの中から607番;CLA607以外のヘテロ分子は削除) CLA(クロロフィルa)選択 [Chlorophyll a - Wikipedia光合成に関係する生体分子PDB 3ARCの部分構造例(本サイト)
(b) ヘム PDBデータ 2hhb(デオキシヘモグロビン,4量体) 同PDBsumデータ 2hhb_HEM(A鎖)$ HEM(ヘム)選択 [Heme - Wikipediaヘモグロビン(本サイト)
(c) ビタミンB12(シアノコバラミン) PDBデータ 1n2zのChain A(ビタミンE輸送タンパク質) 同PDBsumデータ 1n2z_CNC$ CNC(ビタミンB12)選択 [Vitamin B12 - Wikipedia水溶性ビタミンと脂溶性ビタミン(本サイト)
(d) F430 PDBデータ 3pot(メチル補酵素Mレダクターゼ) 同PDBsumデータ 3pot_F43(COM含む;06Cは削除)$ F43(F430)選択 [Coenzyme-B sulfoethylthiotransferase - WikipediaCofactor F430 - Wikipedia
※上記4種のテトラピロール同時表示 4種類のテトラピロール(左上から時計回りでクロロフィルa,ヘム,F430,ビタミンB12) CLA(クロロフィルa)選択 HEM(ヘム)選択 CNC(ビタミンB12)選択 F43(F430)選択
※参考(テトラピロール関連分子) ポルフィリン


ヒトヘモグロビン2HHBとチューブワーム由来ヘモグロビン1YHUのPyMOLによる重ね合わせ表示(何れもChain A)




オキシヘモグロビン1hhoのヘム+O2(空間充填)+近接アミノ酸
CPK色 酸性・中性・塩基性 I/O値順
背景・黒 灰 白 
空間充填 球棒 球60%

デオキシヘモグロビン4hhbのヘム+近接アミノ酸
CPK色 酸性・中性・塩基性 I/O値順
背景・黒 灰 白 
空間充填 球棒 球60%


  
[左]3Dプリンタによるデオキシヘモグロビン2HHB(4量体)の分子模型 [右]4量体模型と「鍵と鍵穴」模型
※新分子模型Kawakami Modelに関する資料はこちらもご覧ください。
本分子模型を使った出張講座・土曜講座の受け付けをしています。



〔左〕ヘモグロビンS2hbs B鎖,〔右〕ヘモグロビン4hhb B鎖



オキシヘモグロビン1HHO A鎖



同4量体(A・B鎖×2)



同4量体のPyMOLによる表示例


  
ヒトのデオキシヘモグロビン2HHBの4量体;右端は必須準必須非必須アミノ酸区別着色



デオキシヘモグロビン2HHB Chain Bのヘム(HEM)近傍



デオキシヘモグロビン2HHBのPDBsumデータ(HEM)



デオキシヘモグロビン2HHBのHEM近傍His(印)

2HHB A鎖(ヘモグロビンα;赤字がFe近傍His)
001-025 Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu Tyr Gly
026-050 Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His
051-075 Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp
076-100 Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
101-125 Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu
126- Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
Ile = 0
Val = 13
Leu = 18
 BCAA = 31(22.0%
Cys = 1
His = 10
Total = 141

2HHB B鎖(ヘモグロビンβ;赤字がFe近傍His)
001-025 Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly
026-050 Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
051-075 Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu
076-100 Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
101-125 Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro
126- Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His
Ile = 0
Val = 18
Leu = 18
 BCAA = 36(24.7%
Cys = 2
His = 9
Total = 146

4MQJ F鎖(胎児ヘモグロビンHbF,ヘモグロビンγ;赤字がFe近傍His)
001-025 Val His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp Gly Lys Val Asn Val Glu Asp Ala Gly Gly
026-050 Glu Thr Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn Leu Ser Ser
051-075 Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile
076-100 Lys His Leu Asp Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
101-125 Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu
126- Val Gln Ala Ser Trp Gln Lys Met Val Thr Gly Val Ala Ser Ala Leu Ser Ser Arg Tyr His
Ile = 4
Val = 14
Leu = 17
 BCAA = 35(24.0%
Cys = 1
His = 7
Total = 146


  
[左]成人のヘモグロビンHbA(1HHO;α2β2)と胎児ヘモグロビンHbF(4MQJ;α2γ2)の比較
[右]胎児ヘモグロビンHbF(1FDH) → PDBj今月の分子 257: 胎児ヘモグロビンJmolトピック

1HHO B鎖(ヘモグロビンβ,I/O値順着色)
Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His
4MQJ F鎖(ヘモグロビンγ,I/O値順着色)
Val His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn Leu Ser Ser
Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile Lys His Leu Asp Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln Ala Ser Trp Gln Lys Met Val Thr Gly Val Ala Ser Ala Leu Ser Ser Arg Tyr His


ヘム近傍PDBsumデータの比較(何れもO2結合)



CO結合カルボモノオキシヘモグロビンのヘム近傍PDBsumデータの比較(1AJ9と4MQC,何れもA鎖)
※V62M変異の4MQCは自己免疫性溶血性貧血のEvans症候群に関係すると考えられる。


  
一酸化炭素が結合した Ni(II)-Fe(II)混成ヘモグロビン6KAEのChain A-DとそのPDBsumデータ(Chain A〈CO結合〉・B) → Jmolトピック
ヘモグロビンによるガス分子運搬の直接観察に成功(横浜市立大学,2020/02/18) …6KAE以外に6KA9・6KAH・6KAI・6KAO〜6KAV・6L5V〜6L5Y・6LCW・6LCX公開


  
ヒトヘモグロビン2HHBとマンモスヘモグロビン3VRFのPyMOLによる表示(何れもChain A)


  
ヘムのPDBsumデータの構成アミノ酸の違い(右はPDBsumデータ2hhb_HEM)



デオキシヘモグロビン3KMFのPDBsumデータ(A鎖HEM,PDBsumデータにH・D追加;中性子回折による座標)



参考:What is a Protein? - YouTube



参考:The flyer What is a Protein? (RCSB PDB) [PDF]
数研出版「フォトサイエンス生物図録」同「チャート式 新化学」講談社ブルーバックス「動く分子事典」p.256なども参照。



★水素原子は省略

消去 針金[2] スティック[3] 球棒[4] 空間充填[5]
Jmol色[1] 原子球白色表示

背景・黒 灰 白 

[ ] の番号順にボタンをクリックしてみましょう!
あとは以下をいろいろ押してみよう。

鍵と鍵穴区別表示1(1次構造;下の“鍵穴構成部品色別表示1”も押して)
鍵と鍵穴区別表示2(2次構造)
全選択 鍵穴を選択 鍵を選択
鍵穴構成部品色別表示1 2 3
鍵穴構造を維持する結合表示

タンパク質の1次構造〜3次構造を知るために(4HHB B鎖を例に;4次構造は冒頭の“4量体”が例)。
分子とは?から順にたどってみよう。


※注:本アニメgif中の2次構造画像にはα-ヘリックスのみでβ-シートは含まれていません。他のJmolコンテンツをご参照ください。


【参考】いろいろな生物のヘモグロビンのアミノ酸配列比較
ヘモグロビンのアミノ酸配列比較例(付記がないものは何れもA鎖);ヒト(2hhb),ヒト胎児HbF(4mqj,B鎖;A鎖はヒトと同じ),マンモス(3vrf),ハツカネズミ(3hrw),ウズラ(3mjp),クロマグロ(1v4w),シロザメ(1gcw),ヤツメウナギ(2lhb),ヌタウナギ(1it3),チューブワーム(1yhu),マシコヒゲムシ(2d2n)  → その他参考:
Glossoscolex paulistusの巨大ヘモグロビン

  
ヘモグロビン構造の比較 [1](何れもA鎖): ヒト(2HHB,デオキシヘモグロビン),マンモス(3VRF,CO結合),シロザメ(1GCW,CO結合),チューブワーム(1YHU)

  
同 [2](何れもB鎖): ヒト(4HHB,デオキシヘモグロビン),ワニ(8WIZ,重炭酸イオン〈HCO3-〉結合)


同 [3](何れもA鎖): ヒト(2HHB,デオキシヘモグロビン),ヤツメウナギ(2LHB,CN-結合),ヌタウナギ(1IT3,CO結合)


同 [4]: ヒト(2HHB),ウマ(6R2O)


同 [5]: ヒト(2HHB)・ウマ(6R2O)・オオカミ(タテガミオオカミ,1FHJ)・イヌ(グレイハウンド,3PEL);何れもA鎖
アミノ酸配列比較Jmolトピック(明石書店「飼いならす」)


同 [6]: サツマハオリムシ(3WCT;24量体,Chain A-H × 3)
【参考(サツマハオリムシ研究例)】 鹿児島湾の奇妙な生き物 サツマハオリムシの全ゲノムを解読 ―化学合成生態系への適応メカニズムに迫る―(東京大学,2023/06/26) [NEW!]
※プレスリリース中の“Toll様受容体(TLR)”についてはToll様受容体参照


同 [7]: 細菌Vitreoscilla stercoraria由来ヘモグロビン(2VHBのA鎖,アジ化物イオンが結合)とそのPDBsumデータ

I/O値順による着色
001-050
ヒト Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His
ヒト B鎖 Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
ヒト胎児HbF B鎖 ** Val His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn Leu Ser Ser
マンモス Val Leu Ser Asp Asn Asp Lys Thr Asn Val Lys Ala Thr Trp Ser Lys Val Gly Asp His Ala Ser Asp Tyr Val Ala Glu Ala Leu Glu Arg Met Phe Phe Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His
ハツカネズミ Val Leu Ser Gly Glu Asp Lys Ser Asn Ile Lys Ala Ala Trp Gly Lys Ile Gly Gly His Gly Ala Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe Ala Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Val Ser His
ウズラ Val Leu Ser Ala Ala Asp Lys Thr Asn Val Lys Gly Ile Phe Ala Lys Ile Ala Gly His Ala Glu Glu Tyr Gly Ala Glu Ala Leu Asp Arg Met Phe Thr Thr Tyr Pro Gln Thr Lys Thr Tyr Phe Pro His Phe Asp Val Ser His
クロマグロ
(X)
Thr Thr Leu Ser Asp Lys Asp Lys Ser Thr Val Lys Ala Leu Trp Gly Lys Ile Ser Lys Ser Ala Asp Ala Ile Gly Ala Asp Ala Leu Gly Arg Met Leu Ala Val Tyr Pro Gln Thr Lys Thr Tyr Phe Ser His Trp Pro Asp
シロザメ Ala Phe Thr Ala Cys Glu Lys Gln Thr Ile Gly Lys Ile Ala Gln Val Leu Ala Lys Ser Pro Glu Ala Tyr Gly Ala Glu Cys Leu Ala Arg Leu Phe Val Thr His Pro Gly Ser Lys Ser Tyr Phe Glu Tyr Lys Asp Tyr Ser Ala
ヤツメウナギ Pro Ile Val Asp Thr Gly Ser Val Ala Pro Leu Ser Ala Ala Glu Lys Thr Lys Ile Arg Ser Ala Trp Ala Pro Val Tyr Ser Thr Tyr Glu Thr Ser Gly Val Asp Ile Leu Val Lys Phe Phe Thr Ser Thr Pro Ala Ala Gln Glu
ヌタウナギ Pro Ile Ile Asp Gln Gly Pro Leu Pro Thr Leu Thr Asp Gly Asp Lys Lys Ala Ile Asn Lys Ile Trp Pro Lys Ile Tyr Lys Glu Tyr Glu Gln Tyr Ser Leu Asn Ile Leu Leu Arg Phe Leu Lys Cys Phe Pro Gln Ala Gln Ala
チューブワーム Ala Cys Ala Met Leu Glu Arg Ala Lys Val Lys Asp Glu Trp Ala Lys Ala Tyr Gly Ile Gly Ala Ala Arg Ser Lys Phe Gly Asp Ala Leu Trp Arg Asn Val Phe Asn Tyr Ala Pro Asn Ala Arg Asp Ile Phe Glu Ser Val Asn
サツマハオリムシ Asp Cys Asn Ile Leu Gln Arg Leu Lys Val Lys Met Gln Trp Ala Lys Ala Tyr Gly Phe Gly Thr Glu Arg Ala Lys Phe Gly Asn Ser Leu Trp Thr Ser Ile Phe Asn Tyr Ala Pro Asp Ala Arg Asp Leu Phe Lys Ser Val Lys
マシコヒゲムシ Val Cys Asn Arg Leu Glu Gln Ile Leu Val Lys Thr Gln Trp Ala Gln Ser Tyr Gly Glu Ala Glu Asn Arg Ala Ala Phe Ser Arg Asp Leu Phe Ser Glu Leu Phe Asn Ile Gln Gly Ser Ser Arg Ala Leu Phe Ser Gly Val Gly
051-100
ヒト Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
ヒト B鎖 Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
ヒト胎児HbF B鎖 ** Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile Lys His Leu Asp Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
マンモス Gly Ser Gly Gln Val Lys Gly His Gly Lys Lys Val Gly Glu Ala Leu Thr Gln Ala Val Gly His Leu Asp Asp Leu Pro Ser Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
ハツカネズミ Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala Asp Ala Leu Ala Ser Ala Ala Gly His Leu Asp Asp Leu Pro Gly Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
ウズラ Gly Ser Ala Gln Ile Lys Gly His Gly Lys Lys Val Ala Ala Ala Leu Val Glu Ala Ala Asn His Ile Asp Asp Ile Ala Gly Thr Leu Ser Lys Leu Ser Asp Leu His Ala Gln Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
クロマグロ Met Ser Pro Gly Ser Gly Pro Val Lys Ala His Gly Lys Lys Val Met Gly Gly Val Ala Leu Ala Val Ser Lys Ile Asp Asp Leu Thr Thr Gly Leu Gly Asp Leu Ser Glu Leu His Ala Phe Lys Met Arg Val Asp Pro Ser Asn
シロザメ Ala Gly Ala Lys Val Gln Val His Gly Gly Lys Val Ile Arg Ala Val Val Lys Ala Ala Glu His Val Asp Asp Leu His Ser His Leu Glu Thr Leu Ala Leu Thr His Gly Lys Lys Leu Leu Val Asp Pro Gln Asn Phe Pro Met
ヤツメウナギ Phe Phe Pro Lys Phe Lys Gly Leu Thr Thr Ala Asp Glu Leu Lys Lys Ser Ala Asp Val Arg Trp His Ala Glu Arg Ile Ile Asn Ala Val Asp Asp Ala Val Ala Ser Met Asp Asp Thr Glu Lys Met Ser Met Lys Leu Arg Asn
ヌタウナギ Ser Phe Pro Lys Phe Ser Thr Lys Lys Ser Asn Leu Glu Gln Asp Pro Glu Val Lys His Gln Ala Val Val Ile Phe Asn Lys Val Asn Glu Ile Ile Asn Ser Met Asp Asn Gln Glu Glu Ile Ile Lys Ser Leu Lys Asp Leu Ser
チューブワーム Ser Lys Asp Met Ala Ser Pro Glu Phe Lys Ala His Ile Ala Arg Val Leu Gly Gly Leu Asp Arg Val Ile Ser Met Leu Asp Asn Gln Ala Thr Leu Asp Ala Asp Leu Ala His Leu Lys Ser Gln His Asp Pro Arg Thr Ile Asp
サツマハオリムシ Ser Glu Asp Met Arg Ser Pro Gln Phe Lys Ala His Ile Ala Arg Val Ile Gly Gly Leu Asp Arg Val Ile Ser Met Phe Asp Asn Glu Asp Ala Leu Asn Ala Asp Leu Glu His Leu Lys Ser Gln His Asp Pro Arg Gly Leu Asp
マシコヒゲムシ Val Asp Asp Met Asn Ser Ala Ala Phe Thr Ala His Cys Leu Arg Val Thr Gly Ala Leu Asn Arg Leu Ile Ser Gln Leu Asp Gln Gln Ala Thr Ile Asn Ala Asp Leu Ala His Leu Ala Gly Gln His Ala Ser Arg Asn Leu Asp
101-
ヒト Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
ヒト B鎖 Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His
ヒト胎児HbF B鎖 ** Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln Ala Ser Trp Gln Lys Met Val Thr Gly Val Ala Ser Ala Leu Ser Ser Arg Tyr His
マンモス Leu Ser His Cys Leu Leu Val Thr Leu Ser Ser His Gln Pro Thr Glu Phe Thr Pro Glu Val His Ala Ser Leu Asp Lys Phe Leu Ser Asn Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
ハツカネズミ Leu Ser His Cys Leu Leu Val Thr Leu Ala Ser His His Pro Ala Asp Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
ウズラ Leu Gly Gln Cys Phe Leu Val Val Val Ala Ile His His Pro Ala Ala Leu Thr Pro Glu Val His Ala Ser Leu Asp Lys Phe Leu Cys Ala Val Gly Thr Val Leu Thr Ala Lys Tyr Arg
クロマグロ Phe Lys Ile Leu Ser His Cys Ile Leu Val Val Val Ala Lys Met Phe Pro Lys Glu Phe Thr Pro Asp Ala His Val Ser Leu Asp Lys Phe Leu Ala Ser Val Ala Leu Ala Leu Ala Glu Arg Tyr Arg
シロザメ Leu Ser Glu Cys Ile Ile Val Thr Leu Ala Thr His Leu Thr Glu Phe Ser Pro Asp Thr His Cys Ala Val Asp Lys Leu Leu Ser Ala Ile Cys Gln Glu Leu Ser Ser Arg Tyr Arg
ヤツメウナギ Leu Ser Gly Lys His Ala Lys Ser Phe Gln Val Asp Pro Glu Tyr Phe Lys Val Leu Ala Ala Val Ile Ala Asp Thr Val Ala Ala Gly Asp Ala Gly Phe Glu Lys Leu Met Ser Met Ile Cys Ile Leu Leu Arg Ser Ala Tyr
ヌタウナギ Gln Lys His Lys Thr Val Phe Lys Val Asp Ser Ile Trp Phe Lys Glu Leu Ser Ser Ile Phe Val Ser Thr Ile Asp Gly Gly Ala Glu Phe Glu Lys Leu Phe Ser Ile Ile Cys Ile Leu Leu Arg Ser Ala Tyr
チューブワーム Pro Val Asn Phe Val Val Phe Arg Lys Ala Leu Ile Ala Thr Val Ala Gly Thr Phe Gly Val Cys Phe Asp Val Pro Ala Trp Gln Gly Cys Tyr Asn Ile Ile Ala Lys Gly Ile Thr Gly Ser Asp Ala Ala
サツマハオリムシ Ala Leu Asn Phe Val Val Phe Gly Lys Ala Leu Phe Ala Thr Val Gly Gly Gln Phe Gly Val Cys Phe Asp Leu Pro Ala Trp Glu Ser Cys Tyr Lys Val Ile Ala Met Gly Ile Thr Gly Asn Asp Met Phe Ser
マシコヒゲムシ Ala Ser Asn Phe Ala Ala Met Gly Gln Ala Val Met Ser Val Val Pro Thr His Leu Asp Cys Phe Asn Gln His Ala Trp Gly Glu Cys Tyr Glu Arg Ile Ala Ser Gly Ile Ser Gly
** A鎖はヒトと同配列。


ヒト必須準必須非必須による着色
001-050
ヒト Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His
ヒト B鎖 Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
ヒト胎児HbF B鎖 ** Val His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn Leu Ser Ser
マンモス Val Leu Ser Asp Asn Asp Lys Thr Asn Val Lys Ala Thr Trp Ser Lys Val Gly Asp His Ala Ser Asp Tyr Val Ala Glu Ala Leu Glu Arg Met Phe Phe Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His
ハツカネズミ Val Leu Ser Gly Glu Asp Lys Ser Asn Ile Lys Ala Ala Trp Gly Lys Ile Gly Gly His Gly Ala Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe Ala Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Val Ser His
ウズラ Val Leu Ser Ala Ala Asp Lys Thr Asn Val Lys Gly Ile Phe Ala Lys Ile Ala Gly His Ala Glu Glu Tyr Gly Ala Glu Ala Leu Asp Arg Met Phe Thr Thr Tyr Pro Gln Thr Lys Thr Tyr Phe Pro His Phe Asp Val Ser His
クロマグロ
(X)
Thr Thr Leu Ser Asp Lys Asp Lys Ser Thr Val Lys Ala Leu Trp Gly Lys Ile Ser Lys Ser Ala Asp Ala Ile Gly Ala Asp Ala Leu Gly Arg Met Leu Ala Val Tyr Pro Gln Thr Lys Thr Tyr Phe Ser His Trp Pro Asp
シロザメ Ala Phe Thr Ala Cys Glu Lys Gln Thr Ile Gly Lys Ile Ala Gln Val Leu Ala Lys Ser Pro Glu Ala Tyr Gly Ala Glu Cys Leu Ala Arg Leu Phe Val Thr His Pro Gly Ser Lys Ser Tyr Phe Glu Tyr Lys Asp Tyr Ser Ala
ヤツメウナギ Pro Ile Val Asp Thr Gly Ser Val Ala Pro Leu Ser Ala Ala Glu Lys Thr Lys Ile Arg Ser Ala Trp Ala Pro Val Tyr Ser Thr Tyr Glu Thr Ser Gly Val Asp Ile Leu Val Lys Phe Phe Thr Ser Thr Pro Ala Ala Gln Glu
ヌタウナギ Pro Ile Ile Asp Gln Gly Pro Leu Pro Thr Leu Thr Asp Gly Asp Lys Lys Ala Ile Asn Lys Ile Trp Pro Lys Ile Tyr Lys Glu Tyr Glu Gln Tyr Ser Leu Asn Ile Leu Leu Arg Phe Leu Lys Cys Phe Pro Gln Ala Gln Ala
チューブワーム Ala Cys Ala Met Leu Glu Arg Ala Lys Val Lys Asp Glu Trp Ala Lys Ala Tyr Gly Ile Gly Ala Ala Arg Ser Lys Phe Gly Asp Ala Leu Trp Arg Asn Val Phe Asn Tyr Ala Pro Asn Ala Arg Asp Ile Phe Glu Ser Val Asn
サツマハオリムシ Asp Cys Asn Ile Leu Gln Arg Leu Lys Val Lys Met Gln Trp Ala Lys Ala Tyr Gly Phe Gly Thr Glu Arg Ala Lys Phe Gly Asn Ser Leu Trp Thr Ser Ile Phe Asn Tyr Ala Pro Asp Ala Arg Asp Leu Phe Lys Ser Val Lys
マシコヒゲムシ Val Cys Asn Arg Leu Glu Gln Ile Leu Val Lys Thr Gln Trp Ala Gln Ser Tyr Gly Glu Ala Glu Asn Arg Ala Ala Phe Ser Arg Asp Leu Phe Ser Glu Leu Phe Asn Ile Gln Gly Ser Ser Arg Ala Leu Phe Ser Gly Val Gly
051-100
ヒト Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
ヒト B鎖 Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
ヒト胎児HbF B鎖 ** Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile Lys His Leu Asp Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
マンモス Gly Ser Gly Gln Val Lys Gly His Gly Lys Lys Val Gly Glu Ala Leu Thr Gln Ala Val Gly His Leu Asp Asp Leu Pro Ser Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
ハツカネズミ Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala Asp Ala Leu Ala Ser Ala Ala Gly His Leu Asp Asp Leu Pro Gly Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
ウズラ Gly Ser Ala Gln Ile Lys Gly His Gly Lys Lys Val Ala Ala Ala Leu Val Glu Ala Ala Asn His Ile Asp Asp Ile Ala Gly Thr Leu Ser Lys Leu Ser Asp Leu His Ala Gln Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu
クロマグロ Met Ser Pro Gly Ser Gly Pro Val Lys Ala His Gly Lys Lys Val Met Gly Gly Val Ala Leu Ala Val Ser Lys Ile Asp Asp Leu Thr Thr Gly Leu Gly Asp Leu Ser Glu Leu His Ala Phe Lys Met Arg Val Asp Pro Ser Asn
シロザメ Ala Gly Ala Lys Val Gln Val His Gly Gly Lys Val Ile Arg Ala Val Val Lys Ala Ala Glu His Val Asp Asp Leu His Ser His Leu Glu Thr Leu Ala Leu Thr His Gly Lys Lys Leu Leu Val Asp Pro Gln Asn Phe Pro Met
ヤツメウナギ Phe Phe Pro Lys Phe Lys Gly Leu Thr Thr Ala Asp Glu Leu Lys Lys Ser Ala Asp Val Arg Trp His Ala Glu Arg Ile Ile Asn Ala Val Asp Asp Ala Val Ala Ser Met Asp Asp Thr Glu Lys Met Ser Met Lys Leu Arg Asn
ヌタウナギ Ser Phe Pro Lys Phe Ser Thr Lys Lys Ser Asn Leu Glu Gln Asp Pro Glu Val Lys His Gln Ala Val Val Ile Phe Asn Lys Val Asn Glu Ile Ile Asn Ser Met Asp Asn Gln Glu Glu Ile Ile Lys Ser Leu Lys Asp Leu Ser
チューブワーム Ser Lys Asp Met Ala Ser Pro Glu Phe Lys Ala His Ile Ala Arg Val Leu Gly Gly Leu Asp Arg Val Ile Ser Met Leu Asp Asn Gln Ala Thr Leu Asp Ala Asp Leu Ala His Leu Lys Ser Gln His Asp Pro Arg Thr Ile Asp
サツマハオリムシ Ser Glu Asp Met Arg Ser Pro Gln Phe Lys Ala His Ile Ala Arg Val Ile Gly Gly Leu Asp Arg Val Ile Ser Met Phe Asp Asn Glu Asp Ala Leu Asn Ala Asp Leu Glu His Leu Lys Ser Gln His Asp Pro Arg Gly Leu Asp
マシコヒゲムシ Val Asp Asp Met Asn Ser Ala Ala Phe Thr Ala His Cys Leu Arg Val Thr Gly Ala Leu Asn Arg Leu Ile Ser Gln Leu Asp Gln Gln Ala Thr Ile Asn Ala Asp Leu Ala His Leu Ala Gly Gln His Ala Ser Arg Asn Leu Asp
101-
ヒト Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
ヒト B鎖 Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His
ヒト胎児HbF B鎖 ** Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln Ala Ser Trp Gln Lys Met Val Thr Gly Val Ala Ser Ala Leu Ser Ser Arg Tyr His
マンモス Leu Ser His Cys Leu Leu Val Thr Leu Ser Ser His Gln Pro Thr Glu Phe Thr Pro Glu Val His Ala Ser Leu Asp Lys Phe Leu Ser Asn Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
ハツカネズミ Leu Ser His Cys Leu Leu Val Thr Leu Ala Ser His His Pro Ala Asp Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
ウズラ Leu Gly Gln Cys Phe Leu Val Val Val Ala Ile His His Pro Ala Ala Leu Thr Pro Glu Val His Ala Ser Leu Asp Lys Phe Leu Cys Ala Val Gly Thr Val Leu Thr Ala Lys Tyr Arg
クロマグロ Phe Lys Ile Leu Ser His Cys Ile Leu Val Val Val Ala Lys Met Phe Pro Lys Glu Phe Thr Pro Asp Ala His Val Ser Leu Asp Lys Phe Leu Ala Ser Val Ala Leu Ala Leu Ala Glu Arg Tyr Arg
シロザメ Leu Ser Glu Cys Ile Ile Val Thr Leu Ala Thr His Leu Thr Glu Phe Ser Pro Asp Thr His Cys Ala Val Asp Lys Leu Leu Ser Ala Ile Cys Gln Glu Leu Ser Ser Arg Tyr Arg
ヤツメウナギ Leu Ser Gly Lys His Ala Lys Ser Phe Gln Val Asp Pro Glu Tyr Phe Lys Val Leu Ala Ala Val Ile Ala Asp Thr Val Ala Ala Gly Asp Ala Gly Phe Glu Lys Leu Met Ser Met Ile Cys Ile Leu Leu Arg Ser Ala Tyr
ヌタウナギ Gln Lys His Lys Thr Val Phe Lys Val Asp Ser Ile Trp Phe Lys Glu Leu Ser Ser Ile Phe Val Ser Thr Ile Asp Gly Gly Ala Glu Phe Glu Lys Leu Phe Ser Ile Ile Cys Ile Leu Leu Arg Ser Ala Tyr
チューブワーム Pro Val Asn Phe Val Val Phe Arg Lys Ala Leu Ile Ala Thr Val Ala Gly Thr Phe Gly Val Cys Phe Asp Val Pro Ala Trp Gln Gly Cys Tyr Asn Ile Ile Ala Lys Gly Ile Thr Gly Ser Asp Ala Ala
サツマハオリムシ Ala Leu Asn Phe Val Val Phe Gly Lys Ala Leu Phe Ala Thr Val Gly Gly Gln Phe Gly Val Cys Phe Asp Leu Pro Ala Trp Glu Ser Cys Tyr Lys Val Ile Ala Met Gly Ile Thr Gly Asn Asp Met Phe Ser
マシコヒゲムシ Ala Ser Asn Phe Ala Ala Met Gly Gln Ala Val Met Ser Val Val Pro Thr His Leu Asp Cys Phe Asn Gln His Ala Trp Gly Glu Cys Tyr Glu Arg Ile Ala Ser Gly Ile Ser Gly
** A鎖はヒトと同配列。
※各表は1文字アミノ酸配列から各種HTMLデータを作成する秀丸マクロ により作成。


【参考】ヘモグロビンとヘモグロビンS
4hhb2hbsのアミノ酸配列の違い(FASTA Sequence,何れもB鎖について)
赤字が最初の共通開始部分トップのMet

※以下にこの配列について,1文字アミノ酸配列から各種HTMLデータを作成する秀丸マクロ により処理したデータを示す。


4HHB(アミノ酸別着色)
Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His


2HBS(アミノ酸別着色)
Val His Leu Thr Pro Val Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His

4HHB(極性・非極性別)
Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His

2HBS(極性・非極性別)
Val His Leu Thr Pro Val Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His


4HHB(I/O値順)
Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His


2HBS(I/O値順)
Val His Leu Thr Pro Val Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr
Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His


《話題》 オキシヘモグロビン・デオキシヘモグロビンとfMRI
 fMRI(機能的磁気共鳴画像)は脳の活動を調べる神経活動計測法の一つであるが,その測定原理となっているのが,オキシヘモグロビンとデオキシヘモグロビンの磁性体としての性質の差である。
 デオキシヘモグロビンの方が常磁性体としての性質をもつので,MRIの強い磁場の中において磁場を乱してMRI信号を減弱させる(Blood oxygen level dependent効果,BOLD効果)。ところが脳の活動が活発化して,網細血管にオキシヘモグロビンが流入するとMRI信号を弱めていたデオキシヘモグロビンが押し出されて信号強度が回復する。この現象による局所的なシグナルの強弱を測定して脳の活動状態を調べるのである。



「生活環境化学の部屋」ホームページJmol版「分子の学習帳」Chime版「分子の学習帳」